* Cancer still top killer in Taiwan: DOH Jun 18, 2009
9 percent), and nephritis, nephritic syndrome and nephrosis (2. 8 percent). (Taipei Times, Taiwan -- Business)
Novel DNA Vaccine Leads To Kidney Damage Prevention In Systemic Lupus Erythematosus Models Jun 18, 2009
ScienceDaily (June 18, 2009) DNA vaccination using lupus autoantigens and interleukin-10 (IL-10, a cytokine that plays an important role in regulating the immune system) has potential as a novel therapy to induce antigen specific tolerance and may help to prevent kidney damage in patients with systemic lupus erythematosus (SLE), according to a new study presented June 11 at EULAR 2009, the Annual Congress of the European League Against Rheumatism in Copenhagen, Denmark. SLE is a complex, chronic... (Science Daily)
Human Genome Sciences shares jump on test results Jun 16, 2009
In March, California-based and Massachusetts-based racked up one of the most recent failures in third-stage clinical trials for a drug to treat lupus nephritis, a kidney inflammation that s a complication of systemic lupus erythematosus. Human Genome Sciences initial Phase II trial for belimumab was conducted with 449 patients in 2005 in a trial that hadn t achieved everything it had set out to do, though patients were measured after less than a year in some cases at that time. (Baltimore Business Journal, MD)
Popular Cancer Drug Linked To Often Fatal Brain Virus May 20, 2009
4, 2009) Treatment with the targeted drug rituximab can significantly benefit some patients with severe lupus nephritis who do not respond to conventional therapy, according to a new study. The findings. (Science Daily)
Lupus Kidney Damage Linked To Malfunction Of Immune Cells Apr 28, 2009
Liu et al. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans ... (May 14, 2007) Good patient information is essential for choosing the best treatment for the kidney disease lupus nephritis ... 4, 2009) Treatment with the targeted drug rituximab can significantly benefit some patients with severe lupus nephritis who do not respond to conventional therapy, according to a new study. (Science Daily)
BioMarin returns rights to lupus drug Apr 3, 2009
But an independent data monitoring committee said Feb. 12 that continuation of a Phase III study of Riquent for lupus nephritis kidney disease characterized by extreme, acute inflammation was futile. The trial and further development of Riquent was discontinued. (San Francisco Business Times, CA)
Protective Role For Kallikrein Proteins In Kidney Disease Apr 3, 2009
3, 2009) A team of researchers, at the University of Texas Southwestern Medical Center, Dallas, and Uppsala University, Sweden, has shed new light on several forms of the kidney disease known as nephritis ... Specifically, the data indicate a protective role for kallikrein proteins in anti-GBM antibody induced nephritis (a mouse model of Goodpasture syndrome) and spontaneous lupus nephritis in mice and humans ... In the study, which was led by Chandra Mohan, Edward Wakeland, and Marta... (Science Daily)
Biogen Idec lupus trial fails Mar 13, 2009
Massachusetts' Biogen Idec (Nasdaq: BIIB) and California-based (NYSE: DNA) announced after the close of the stock market Wednesday that their phase III clinical trial using the drug Rituxan in combination with other drugs to treat lupus nephritis failed to meet its primary endpoint ... Lupus nephritis is an inflammation of the kidney and a complication of lupus, an autoimmune disease that causes inflammation in different organs. (Raleigh Triangle Business Journal, NC)
Roche Completes $46.8 Billion Deal for Genentech Mar 13, 2009
Although analysts welcomed the deal, which is ending months of uncertainty, Roche shares traded lower because Rituxan, its best-selling drugs, had failed to meet the primary goal in a study that investigated its potential in treating lupus nephritis. At 1015 GMT, Roche shares were down CHF4, or 2. (SmartMoney)
Rituxan fails in lupus test Mar 12, 2009
Rituxan is approved for use in rheumatoid arthritis and non-Hodgkin lymphoma, and the companies hoped to get it approved as a treatment for lupus nephritis. The companies said they will still look for new ways to treat lupus. (Boston Globe)
Genentech says lupus tests fell short Mar 12, 2009
Lupus nephritis is an inflammation of the kidney and a complication of systemic lupus erythematosus, an autoimmune disease. We are disappointed that Rituxan did not show a significant benefit in patients with lupus nephritis, a complex and serious disease. (San Jose Business Journal, CA)
Canine Lyme Disease Nephritis Mar 7, 2009
Though the most common symptom of in dogs is lameness caused by joint pain and swelling, veterinarians are also recognizing a form of the disease referred to as Lyme nephritis ... Lyme disease nephritis symptoms are those of renal failure and may consist of ... Diagnosing nephritis caused by Lyme disease is based on identifying a positive Lyme disease antibody test using either a Idexx SNAP 3DX or 4DX or a quantitative C6 antibody level along with evidence of renal involvement. (Suite101.com)
Autism and vaccines: What's the link? Mar 22, 2008
Other symptoms include chorea, athetosis, tremors, convul- sions, pain and numbness in the extremities, nephritis, salivation, loosening of the teeth, blue line on the gums, anxiety, mental depression, insomnia, hallucinations and central nervous system effects [301. Exposure may also cause irritation of the eyes, mucous membranes and upper respiratory tract [269. (Atlanta Journal-Constitution -- Opinion)
Adult With Two Colons Suffers Kidney Atrophy: Rare Diagnosis In The Operation Room Feb 27, 2008
(May 14, 2007) Good patient information is essential for choosing the best treatment for the kidney disease lupus nephritis. A Dutch researcher concludes this following her doctoral research into two methods for. (Science Daily)
Immunosuppressant Further Linked To Birth Defects, Case Study Suggests Feb 13, 2008
In fact, 3 out of 10 babies described in the literature regarding these defects had mothers on MMF because of lupus nephritis. Led by Dr. Antonio Perez-Aytes and Dr. Maximo Vento of the Newborn Research Unit at the Hospital Universitario Materno-Infantil La Fe, in Valencia, Spain, the study describes a 25-year-old Spanish woman who had undergone two kidney transplants. (Science Daily)
A Woman with Postpartum Visual Loss, Shortness of Breath, and Renal Failure Jan 17, 2008
Tubulointerstitial Nephritis Uveitis. Wegener's Granulomatosis or Microscopic Polyangiitis. (New England Journal of Medicine)
Tech startup gets lift at conference Dec 15, 2007
Azano Pharmaceuticals, developing a protein drug product to treat lupus nephritis. CareerTours, creates audio and video "tours" of a company aimed at jobseekers. (AZCentral -- Business)
ZymoGenetics and Merck Serono Initiate Phase 2/3 Clinical Trial of Atacicept in Lupus Nephritis Dec 13, 2007
Trial will Evaluate Safety and Efficacy of Atacicept in Lupus Nephritis and is Intended to Support Marketing Authorization. NEW YORK--()--ZymoGenetics, Inc. (NASDAQ: ZGEN) and Merck Serono, a division of Merck KGaA, announced today the initiation of a Phase 2/3 clinical trial of atacicept in lupus nephritis, a severe form of systemic lupus erythematosus (SLE) ... This study will evaluate the efficacy and safety of atacicept for the treatment of patients with active lupus nephritis. (BusinessWire)
Researchers investigate ways to detect lupus-associated kidney disease Nov 13, 2007
Given that early intervention in lupus nephritis is associated with better treatment outcome, it is imperative that disease activity in the kidney be diagnosed as early as possible ... When the antibodies attack the kidneys, nephritis occurs, often shortening a patients life expectancy ... Dr. Mohan and colleagues screened urine from mice with lupus nephritis for the presence of four compounds VCAM-1, P-selection, TNFR-1 and CXCL 16. (EurekAlert!)
Antiphospholipid Syndrome Oct 21, 2007
cfm/lupus_nephritis in patients with coexisting systemic lupus erythematosus (SLE) ... In patients with coexisting conditions of APS, systemic lupus erythematosus, and lupus nephritis, have been implicated. (Suite101.com)
Anti-inflammatory drugs: When to use? Oct 11, 2007
Aleve, for example warns against constipation, heartburn, abdominal pain, nausea, headache, dizziness, drowsiness, rash, tinnitis, edema, nephritis (inflammation of the kidneys), Nephrotis syndrome, jaundice and hepatitis. According to an article in the American Journal of Medicine, complications related to NSAID use among arthritis patients are responsible for 16,500 deaths per year in the United States. (Saugus Advertiser, MA)
Altadena cemetery breathes new life into Hollywood legend Sep 30, 2007
Official accounts of her death in 1926 at her Altadena home on Boston Street list the cause as tuberculosis and nephritis -- inflammation of the kidney. She may have been the only screenwriter to persuade a dictator to appear in a film: Benito Mussolini played himself in the now-vanished 1923 film "The Eternal City," which La Marr starred in and for which she was reported to have done uncredited writing and producing. (Los Angeles Times)
Number of kidney patients on rise in Bangladesh Sep 17, 2007
The report mentioned diabetes, nephritis and hypertension as the main reasons for kidney damage. Since the treatment facilities are limited in this South Asian country, most of kidney patients are going to neighboring India and other developed countries for treatment, making the country lose millions of hard earned foreign exchange annually, the report said. (Xinhuanet, China)
Americans living longer than ever Sep 13, 2007
Heart disease Malignant neoplasms (cancer) Cerebrovascular diseases (stroke) Chronic lower respiratory diseases Accidents (unintentional injuries) Diabetes mellitus (diabetes) Alzheimers disease Influenza and pneumonia Nephritis, nephrotic syndrome and nephrosis (kidney disease) Septicemia Intentional self-harm (suicide) Chronic liver disease and cirrhosis Essential (primary) hypertension and hypertensive renal disease (hypertension) Parkinsons... (MSNBC -- Health)
Aspreva Provides Update On Lupus Nephritis Development Program Sep 10, 2007
VICTORIA, British Columbia, Sept. 10, 2007 (PRIME NEWSWIRE) -- Aspreva Pharmaceuticals Corporation (NasdaqGS: - ) (Toronto: - ) today announced that Aspreva and Roche have decided not to proceed with a regulatory submission at this time for CellCept as an induction therapy for lupus nephritis ... Preliminary results from the induction stage of Aspreva's phase III clinical trial comparing CellCept (oral mycophenolate mofetil, MMF) to intravenous cyclophosphamide (IVC) for inducing treatment... (Primezone Releases)
Aspreva and Roche Update CellCept Agreement Aug 29, 2007
Through this agreement, Aspreva will contribute to clinical development work in lupus nephritis undertaken by Roche in China ... Forward-looking statements in this news release include, but are not limited to, statements about: our strategy, future operations, clinical trials, prospects and plans of management; our expectations regarding future revenues and expenses; the effects of CellCept on patients; our expectations with respect to our existing collaboration agreement with Roche for the... (Primezone Releases)
Pocatello's history explored Jun 30, 2007
D.W. and Emma's daughter Cammie died young of nephritis (though many Pocatellans still like to think she hung herself in the hallway of the Standrod House). The Standrods were not the most popular people in Pocatello in some circles, but they were respected. (Pocatello Idaho State Journal, ID)
* Aborigines of Wadeye: a portrait of neglect Jun 28, 2007
Residents suffer high rates of heart disease, rheumatic fever, skin sepsis and nephritis. Some 20 to 30 percent of children have perforated ear drums due to chronic infection. (Taipei Times, Taiwan -- World)
Outcasts in their own land Jun 24, 2007
Residents suffer high rates of heart disease, rheumatic fever, skin sepsis and nephritis. Some 20 to 30 per cent of children have perforated ear drums due to chronic infection. (Guardian Unlimited -- World)
Choirs gather to help local girl with lupus Jun 9, 2007
" The event will start at 5 p.m. Saturday at Files Chapel Baptist Church, 900 Dixie St.Crystal, known as "Gabby," was diagnosed with lupus nephritis in 2002.Lupus is a disease of the immune system, and lupus nephritis is an inflammation of the kidney caused by systemic lupus.Since moving to Charlotte with her family in February, her mother, Yolanda Corey, said Gabby has gotten worse. She has been treated for pneumonia, doctors found blood clots, she has undergone chemotherapy, had renal failure... (Foster's Daily Democrat)
Thursday's Stocks to Watch Jun 7, 2007
Aspreva Pharmaceuticals Corp. () () said the Food and Drug Administration has granted fast-track designation for CellCept for the treatment of lupus nephritis. CellCept is Roche's () leading immunosuppressant or "anti-rejection" drug used i 00000719 n combination with other drugs for the prevention of rejection in patients receiving heart, kidney and liver transplants. (Fox News)
Aspreva announces Fast-Track designation granted by the FDA for CellCept in lupus nephritis Jun 7, 2007
VICTORIA, June 6 /PRNewswire-FirstCall/ - Aspreva Pharmaceuticals Corporation (NASDAQ: ; TSX: ASV) today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation for CellCept (mycophenolate mofetil, MMF) for the treatment of lupus nephritis. Aspreva is currently evaluating CellCept for the treatment of lupus nephritis in a global phase III study ... In granting Fast Track designation, the FDA noted that type III-V lupus nephritis is a severe inflammation of... (PR Newswire)
Hospitalized student shows signs of improvement Jun 5, 2007
Also, at 2:54 p.m. Friday Shellie posted that doctors believe he became sick from acute post-streptococcal glomerular nephritis, associated with a streptoccal infection. Lee had been diagnosed about three weeks ago with a sinus infection, Wages said Thursday. (Dublin Courier Herald, GA)
Aspreva Completes Expanded Patient Enrollment in Phase III Clinical Trialfor CellCept in Pemphigus Vulgaris May 23, 2007
Forward-looking statements in this news release include, but are not limited to, statements about: our strategy, future operations, clinical trials, prospects and plans of management; our ability to evaluate the potential efficacy of mycophenolate mofetil in the treatment of pemphigus vulgaris; the effects of CellCept on patients; our expectations with respect to our existing collaboration agreement with Roche for the development of CellCept in autoimmune indications; and our two phase III... (PR Newswire)
No Wonder His Name Is A.A. May 19, 2007
"I drank steadily, with a steely determination. I drank on and through peripheral nephritis, alcoholic gastritis, an atrophied brain, an enlarged liver, a damaged pancreas, blackouts, suicidal depression, anonymous bloody sores and DTs so severe that I would have to take the first drink of the morning using a towel hooked round my neck as a pulley, because I was frightened of knocking my teeth out with the glass.". Gill, a dyslexic, says he began drinking as an insecure boarding-school boy who... (New York Post -- Gossip)
Treatment Of Kidney Condition Requires An Individualized Approach May 16, 2007
Good patient information is essential for choosing the best treatment for the kidney disease lupus nephritis. Dutch researcher Cecile Grootscholten concludes this following her doctoral research into two methods for treating lupus nephritis ... The severity of the kidney disease lupus nephritis varies and the side effects of the treatments differ as well. (Science Daily)
Oregon joins national organ donor registryGiving takes more than a 'D' on your driver’s license Apr 29, 2007
Ray received her kidney in 2003 after being on dialysis for three and a half years with glomero nephritis, a disease that causes kidney failure. She was 69 when she received her new kidney; the donor was a 55-year-old woman who died of a stroke. (Albany Democrat-Herald, OR)
Honoured Lomu thanks donor for life Apr 11, 2007
Sign up to the Rugby Heaven newsletter for your chance to win Super 14 tickets. Want to link your website to rugbyheaven. (Sydney Morning Herald -- Sport)
Black-White Life Expectancy Gap Narrows Mar 18, 2007
Moreover, "unfavorable trends in nephritis and septicemia are currently contributing to widening the gap," he said. The researchers concluded that "future efforts to reduce the black-white gap should be aimed at reducing existing inequalities in cardiovascular risk factors, particularly hypertension, and improving access to effective treatment for existing disease that remain underused.". (MedPage Today)
Black-white life expectancy gap narrows, but remains substantial Mar 17, 2007
"Homicide, HIV, and perinatal death, although demonstrating favorable trends, continue to keep the black-white gap unnecessarily large, and unfavorable mortality trends in nephritis [kidney disease] and septicemia [bloodstream infection] are currently contributing to widening the gap," the authors write. The authors emphasize that further narrowing of the gap will require concerted efforts to address the major causes of the remaining gap. (EurekAlert!)
Lupus Nephritis Mar 15, 2007
Kidney Disease in Lupus, RA, and Scleroderma. Kidney disease in lupus typically emerges within the first five years after diagnosis, and it rarely develops in people who have had SLE for as long as 10 years. (Suite101.com)
New Blood Thinner Studied For Patients With Leg And Lung Clots Feb 14, 2007
A new oral blood thinner is being compared to an old standby to see if it works as well and is easier to manage long term, researchers say. Dr. James R. Gossage Jr., pulmonologist at the Medical College of Georgia. (Science Daily)
Mother, daughter get kidneys from brothers Jan 23, 2007
She knows that her diagnosis is chronic glomerular nephritis, which slowly shut down her kidneys. But Schultz will never know for sure why McKasson's kidneys stopped functioning. (Newsday)
Active Ingredient In Common Chinese Herb Shown To Reduce Hypertension Jan 20, 2007
Some 50 million Americans have hypertension, that is, blood pressure measuring above the normal range (less than 120/80 mmHg). If untreated, it can lead to heart attacks, strokes, or kidney disease. (Science Daily)
Genentech Q4 2006 Earnings Call Transcript Jan 11, 2007
We anticipate completing enrollment in the Phase II/III SLE study, EXPLORER, in quarter one 2007; and in the Phase III Lupus nephritis study, LUNAR, in the second half of this year ... We are also preparing to initiate two Phase III Lupus studies, one in SLE and one in Lupus nephritis in the first half of 2007. (Seeking Alpha)
