Researchers Discover Natural Inflammation-fighting Mechanism In Body-fat Cells Jun 5, 2008
Cellular stress caused by obesity, however, can override this protective function and convert the pathway into a trigger of chronic inflammation that raises the risk of insulin resistance, diabetes, and other metabolic disorders. See also. (Science Daily)
Researchers ID Inflammation-Fighting Pathway in Fat Cells Jun 4, 2008
However, the researchers also found that obesity-related cellular stress can override the protective function and turn the pathway into a trigger of chronic inflammation, leading to increased risk of insulin resistance, diabetes and other metabolic disorders. In lean people, the newly identified signaling pathway acts as a natural counterbalance to a parallel signaling pathway that promotes inflammation and can lead to health problems. (Health-Finder)
Men and Women May Metabolize Fructose Differently Jun 4, 2008
"Hence, gender has to be taken into consideration in studies evaluating the relationship between nutrition and metabolic disorders," Tappy told Reuters Health ... "One burning question is whether fructose may have more deleterious effects in individuals at high risk for metabolic disorders," Tappy surmises. (MEDLINEplus)
State's health care for kids ranks seventh Jun 1, 2008
She said Hawaii does well with screening infants for metabolic disorders -- "virtually 100 percent for hearing disorders" -- and intervention programs. "But again, we do need to look at issues of asthma, obesity and quality of care. Certainly, we can do a lot better about coordinating services and continually looking at the quality of services being provided.". (Honolulu Star-Bulletin)
Daiichi Sankyo Co., Ltd. Announces Acquisition of Biotech Firm U3 Pharma AG May 21, 2008
The company uses its cumulative knowledge and expertise in the fields of cardiovascular disease, cancer, metabolic disorders, and infection as a foundation for developing an abundant product lineup and Rline. For more information, visit. (PR Newswire)
MDS Pharma Services Strengthens Therapeutic Focus on Respiratory and Metabolic Disorders May 20, 2008
Dr. Bernard Tisserand and Dr. Jonny Salyer appointed Executive Medical Directors to provide leadership and expertise for late stage clinical studies KING OF PRUSSIA, PA, May 20 /CNW/ - MDS Pharma Services, a leading provider of innovative drug discovery and development solutions, has named two experienced medical professionals to lead its late stage clinical trial management activities related to respiratory ailments and metabolic disorders. Dr. Bernard Tisserand and Dr. Jonny L. Salyer have... (Canada Newswire)
Number Of Fat Cells Remains Constant From Teenhood In All Body Types May 13, 2008
Obesity is increasing in epidemic proportions in most countries and poses a public health problem by enhancing the risks for cardiovascular diseases and metabolic disorders such as type 2 diabetes. According to the Centers for Disease Control and Prevention, the prevalence of overweight and obesity has increased sharply for both adults and children since the 1970s. (Science Daily)
New Study Shows How Genes Control Blood Proteins Important To Health May 12, 2008
ScienceDaily (May 11, 2008) A new study shows how genes control levels of many blood proteins implicated in disease. The findings are the result of an international collaboration between scientists at the University of Exeter, the National Institute on Aging, and the Tuscany and Florence Health Agencies. (Science Daily)
On Your Mind May 12, 2008
This must be a real irritant to those with chronic metabolic disorders who must closely watch their nutrient intake. You have an opportunity to do a service to your readers. (Sierra Vista Herald, AZ)
Ranbaxy set to ink deal with Merck May 10, 2008
In another major deal, Nicholas has also signed an agreement with Eli Lilly for drugs targeting metabolic disorders, where it could receive $100 million in royalty payments. This Merck-Ranbaxy deal is expected to identify target drugs antibiotic compounds, and the domestic company will develop and research on it, taking it to the stage of clinical trials. (India Times, India -- Intl Business)
Ranbaxy to ink R&D deal with foreign co May 10, 2008
For instance, Merck had recently entered into an agreement with Nicholas Piramal for oncology drugs besides its deal with Tata Group-controlled Advinus for metabolic disorders. Discuss this story with other readers. (Economic Times)
Genetic Breakthrough Explains Dangerously High Blood Glucose Levels May 4, 2008
These findings provide important insights into the genetic mechanisms behind glucose metabolism, say the researchers, which they predict will lead to greater understanding of the genetic roots of metabolic disorders in general. "In theory, any medical test which has a genetic component can use this approach," Sladek explained. (Science Daily)
State screening might be removed Apr 22, 2008
Children born with several metabolic disorders will be sentenced to mental retardation and possibly death, simply because they were born in our state. Newborn screening has repeatedly been demonstrated to save money. (Florida Times-Union)
Herceptin(R) Helps Eradicate HER2-Positive Breast Tumours When Given Before Surgery Apr 18, 2008
" The GeparQuattro results are consistent with other Herceptin neoadjuvant studies, such as NOAH (NeOAdjuvant Herceptin, including 228 evaluable HER2-positive patients)(2) and TECHNO (Taxol-Epirubicin-Cyclophosphamid-Herceptin Neoadjuvant), reinforcing the strong evidence for the benefits associated with Herceptin in the early stages of HER2-positive breast cancer. "It is very reassuring to see that the GeparQuattro study confirmed the significant benefits observed with Herceptin in other... (Canada Newswire)
Early dementia often caused by autoimmune disorders Apr 16, 2008
2 percent and Alzheimer's disease was seen in less than 1 percent," data presented by Kelley showed. Autoimmune-inflammatory causes, including multiple sclerosis, accounted for 21.2 percent. Inborn errors of metabolism were identified in 10.6 percent. At the last evaluation, the cause of dementia was still unknown in 44 patients (18.7 percent) despite exhaustive evaluations, Kelley reported. Inborn errors of metabolism were more common in individuals with symptoms appearing before age 30.... (Reuters)
* Death before life Apr 8, 2008
Older women; blacks; women with an underlying disease like diabetes, hypertension, clotting or metabolic disorders; women who had a prior Caesarean delivery; and those who remain pregnant well past their due date also face a higher-than-average risk of stillbirth. If a genetic or chromosomal abnormality was the cause of a stillbirth, the risk of recurrence can vary from 1 percent if the baby had an extra chromosome to as high as 50 percent for genetic disorders like familial DiGeorge syndrome. (Taipei Times, Taiwan -- World)
Natural trans fats have health benefits, University of Alberta study shows Apr 3, 2008
The role of chylomicrons is increasingly viewed as a critical missing link in the understanding of conditions arising from metabolic disorders. Our results provide further evidence of the important role of chylomicrons in contributing to risk factors associated with metabolic disorders, said Wang, a PhD candidate in the University of Alberta Faculty of Agricultural, Life and Environmental Sciences. (EurekAlert!)
Obesity drug shows weight loss in study Apr 1, 2008
"Based on the benefit-risk considerations and the lack of a substantial improvement in the efficacy of taranabant at the 4-milligram and 6-milligram doses seen in our clinical program compared to the 2-milligram dose, we have decided to continue to evaluate taranabant in doses up to and including 2 milligrams in our Phase III studies," said Dr. John Amatruda, vice president of clinical research, metabolic disorders, for Merck, in a statement. The findings were presented at the American College... (MSNBC -- Health)
Normal Weight Doesn't Always Equal Healthy Weight Apr 1, 2008
And, like their overweight contemporaries, this makes them susceptible to heart disease, diabetes and other metabolic disorders, a new study says. Men whose body fat is greater than 20 percent and women whose body fat is greater than 30 percent are suffering from "normal weight obesity," the study authors said, even though their weight may be normal for their size. (Health-Finder)
Smart Clothes: Textiles Track Your Health Mar 31, 2008
Nevertheless, in the long-term we expect continuous monitoring, made possible with smart textiles, to make a major improvement to the way we approach the treatment of metabolic disorders and leisure. Adapted from materials provided by. (Science Daily)
CDC: Vaccines' benefits outweight dangers Mar 26, 2008
Fevers cause crises in people with metabolic disorders ... Fevers cause crises in people with metabolic disorders ... Fevers cause crises in people with metabolic disorders. (Atlanta Journal-Constitution -- Opinion)
Dr. Reddy's Mode of Discovery Mar 20, 2008
We are renewing our focus on metabolic disorders and are working on several new partnerships to improve our pipeline. We must recognize that drug discovery is a long-term investment, and it will take time to realize the benefits. (BusinessWeek)
Studies Find Obesity Is the Result of Complex Networks of Genes Mar 18, 2008
In two related studies, scientists at Merck Research Laboratories (MRL) and their collaborators used large-scale analyses of data on DNA variations, gene expression patterns in disease-relevant tissues and clinical data to identify molecular networks underlying metabolic disorders. The first study, involving Merck researchers and colleagues from the University of California at Los Angeles, used liver and fat tissue samples from mice to identify genetic variations associated with obesity,... (eFluxMedia)
Reports to detail top targets of Pa. biopharm companies Mar 17, 2008
17 companies are working on 70 therapies for metabolic disorders. The data -- which involve drug companies based here or with a large presence in the state -- will be used to support the life sciences industry's push for continued support in Harrisburg during budget season. (Philadelphia Business Journal, PA)
Gene hunters uncover networks behind disease Mar 17, 2008
And it confirms the importance of the immune system in metabolic disorders such as obesity: a similar study in mice led by Schadt determined that a group of genes related to obesity are also involved in inflammation. ADVERTISEMENT. (Nature News Service)
Sigma-Aldrich, Oxford BioMedica and Open Biosystems Settle Patent Dispute Over Use of LentiVector Technology in Research Reagents Mar 8, 2008
These research tools provide investigators with standardized high-quality genes, RNAi and antibodies for interrogating gene function in relation to oncology, neuroscience and metabolic disorders. Founded in 2001, Open Biosystems is headquartered in Huntsville, Alabama. (PR Newswire)
Antipsychotic Abilify Can Be Used In Teens With Bipolar: FDA Mar 6, 2008
It was found out that Abilify has slightly an edge over the other antipsychotics in the sense that it does not have the side effects like weight gain and other metabolic disorders. The major problem with second-generation antipsychotic drugs is weight gain and diabetes. (MedIndia)
Fire in the Hole Feb 23, 2008
1) "Climate has been an important selective pressure acting on candidate genes for common metabolic disorders." 2) Specifically, our ancestors "had to develop genetic variants that made them more efficient in terms of energy metabolism and that made them more able to cope with cold climates by increasing their ability to generate and maintain heat." 3) Today, "We eat a lot more, we don't exercise nearly as much as our ancestors used to do, and these adaptations that made us cope well to a... (Slate)
Goldilocks Diet’ Just Right For Some Cows Feb 21, 2008
And that fat can contribute to a high incidence of metabolic disorders and infectious diseases around calving, Drackley reminded. These disorders and diseases create problems on dairy farms. (Agri-View, WI)
Surgery will do more than education to fix the obesity epidemic Feb 19, 2008
Interestingly, a recent study in the US suggested that people who drank even diet soft drink regularly were more likely to be obese and suffer other metabolic disorders. Science is also closer to solving the puzzle of why most dieters fail to maintain weight loss and end up heavier than they started. (The Age)
Roche Completes Tender Offer for Ventana Shares Feb 19, 2008
It is also active in other major therapeutic areas such as autoimmune diseases, inflammatory and metabolic disorders and diseases of the central nervous system. In 2007 sales by the Pharmaceuticals Division totaled 36. (PR Newswire)
Second diabetes study produces much different results Feb 15, 2008
"I think our current goal for achieving blood sugar control in patients with Type 2 diabetes is based on information accumulated over decades," said Dr. Kenneth Hupart, chief of endocrinology, diabetes and metabolic disorders at Nassau University Medical Center. "To look at these studies as reasons to alter current care would not be advised.". (Houston Chronicle)
CASTLE study showed similar efficacy between once-daily REYATAZ(R) (atazanavir sulfate)/ritonavir and twice-daily lopinavir/ritonavir at 48 weeks in previously untreated HIV-infected adult patients Feb 7, 2008
Bristol-Myers Squibb Canada is a leading provider of medicines to fight cancer, cardiovascular and metabolic disorders, infectious diseases (including HIV/AIDS), nervous system diseases and serious mental illness. Bristol-Myers Squibb Company is listed on the New York Stock Exchange under the BMY symbol. (Canada Newswire)
Insception Biosciences Begins Human Clinical Trials of Stem Cell Treatment That Could Replace Bone Marrow Transplants Feb 6, 2008
There are also hundreds of Canadians in need of bone marrow transplants each year to treat a wide variety of illnesses, including blood-related diseases such as leukemia, and inherited immune system and metabolic disorders, according to the Canadian Blood Services. For most of these patients, a bone marrow transplant may be the last and best chance for recovery from a serious illness. (Canada Newswire)
Schools keep beef off menus Feb 2, 2008
"Most downers are the result of traumatic injuries or metabolic disorders," Baszler said. Because the nation's first known "mad cow" in 2003 was a downer identified on a ranch in Eastern Washington, he said it's natural for the public to wonder if downers pose a greater threat of passing on that infection (technically, BSE, bovine spongiform encephalopathy). (Seattle Post Intelligencer)
Patients to go for stem cell therapy annually in India Feb 2, 2008
These centres will offer therapy to treat 75 diseases such as blood disorders, thalassemia, leukaemia, certain metabolic disorders and cancer with a 90% success rate. While we will start with stem cell transplantation, concurrent pilot stage trials will go on for other therapies, Cryobanks CEO C V Nerikar said. (Economic Times)
Cell Fate Determination: Notch-ing Glucose Into Place Feb 1, 2008
Funding for this work comes from the National Institutes of Health, the Astellas Foundation for Research on Metabolic Disorders and the Howard Hughes Medical Institute. Adapted from materials provided by. (Science Daily)
Beat Lower Milk Prices By Boosting Protein Content Feb 1, 2008
Hutjens mentioned fewer metabolic disorders like fatty liver syndrome, along with an increase in fertility because of lower blood urea nitrogen (BUN). Protein sources. (Agri-View, WI)
Notch-ing glucose into place Jan 28, 2008
Funding for this work comes from the National Institutes of Health, the Astellas Foundation for Research on Metabolic Disorders and the Howard Hughes Medical Institute. Once the embargo is lifted, the article or an abstract can be found at. (EurekAlert!)
TransTech acquires Novo Nordisk programs Jan 27, 2008
TransTech Pharma has acquired the rights to three treatment programs under development for metabolic disorders from Novo Nordisk. Novo Nordisk, which is based in Denmark, decided last year to focus on protein-based pharmaceuticals and began divesting its small-molecule drug candidates. (Business Journal of the Greater Triad Area)
Adaptive Functional Evolution Of Leptin In Cold-adaptive Pika Family Jan 25, 2008
"But the study of adaptively functional evolution of pika leptin from a typical cold-adaptive species may enlighten us to understand and to identify it as one of potential new candidate of therapeutic strategies for human's diseases associated with metabolic disorders, such as obesity, diabetes, osteoporosis, etc". "Now our research team is carrying out the functional experiments of pika leptin to further confirm this viewpoint," said Dr Zhao. (Science Daily)
Campus Notes Jan 23, 2008
Penn State's Rhonda Belue will be speaking about "Addressing the Increasing Prevalence of Metabolic Disorders in West Africa: A Review and Potential Intervention Strategies," at noon today in 216 Willard Building. Africana Research Center + Alliance for Earth Sciences, Engineering and Development in Africa will host the event. (Daily Collegian, PA)
Rest covered from A to Zzz's Jan 18, 2008
And dysfunction in those activities could have links to heart disease, high blood pressure and metabolic disorders that could manifest themselves in diabetes and hypoglycemia, not to mention the traffic and industrial accidents resulting from poor concentration induced by poor sleep. "Sleep in general wasn't given enough attention as being vital to your health in so many ways," Wahba said. (Daytona Beach News Journal)
Synergy Life Science closes $143M fund Jan 11, 2008
Areas of therapeutic interest include cardiovascular disease, orthopedic and spinal diseases and injuries, metabolic disorders such as diabetes and obesity, neuro-mediated disorders, oncology and ophthalmic conditions. Related Industry News. (San Jose Business Journal)
Synergy Life Science Partners Closes $143M Debut Medical Device Fund Jan 10, 2008
Areas of therapeutic interest include cardiovascular disease, orthopedic and spinal diseases and injuries, metabolic disorders such as diabetes and obesity, neuro-mediated disorders, oncology and ophthalmic conditions. "We're excited about our fundraising accomplishments and our early portfolio," said Onopchenko, a managing director of Synergy. (PR Newswire)
Cary's Cetero buys DGD Research of Texas Jan 9, 2008
It said the purchase will add to its capability to conduct early-stage trials on patients with endocrine or metabolic disorders, such as diabetes and heart disease. "The addition of DGD Research to the Cetero family provides unrivaled experience with patient populations to our phase I-IV capabilities in therapeutic research, especially within the endocrinology and metabolic disorder areas," Jerry Merritt, CEO of Cetero Research, said in a written statement. (Raleigh Triangle Business Journal, NC)
Modified Protein May Lead To First Cure For Cirrhosis Of The Liver Dec 29, 2007
Excessive tissue repair in chronic liver disease induced by viral, toxic, immunologic and metabolic disorders all result in excessive scar tissue, and could benefit from therapy developed from the UCSD researchers' findings. The research was supported by grants from the National Institutes of Health, the Department of Veterans Affairs and UCSD's Medical Research Foundation. (Science Daily)
Liver Fibrosis Can Be Stopped, Cured and Reversed Dec 29, 2007
SIGN UP FOR FREE NEWS ALERTS. Friday, December 28, 2007 9:08 AM. (Newsmax)
Researchers show that fibrosis can be stopped, cured and reversed Dec 27, 2007
The peptide also directly activated the caspase or executioner" protein, which killed the cells producing liver cirrhosis but not the normal cells. All control mice had severe liver fibrosis, while all mice that received the RSK-inhibitory peptide had minimal or no liver fibrosis, said Buck. Buck explained that the excessive collagen response is blocked by the RSK-inhibitory peptide, but isnt harmful to the liver. The cells continue to do their normal, healing work but their excess... (EurekAlert!)
ARYx Therapeutics Provides Update on Product Development -- Reports Results for 2007 Third Quarter Dec 20, 2007
ATI-9242 has been designed to minimize the toxicities associated with metabolic disorders such as weight gain and diabetes often resulting from the use of atypical antipsychotics. Forward-looking Statements. (BusinessWire)
ECB puts $502.5 billion into money markets Dec 19, 2007
The Merck deal is to develop a therapeutic protein to treat Type 2 diabetes and related metabolic disorders such as obesity. The Eli Lilly collaboration focuses on treatments in a number of areas including metabolic diseases and central nervous system disorders. (San Diego Union-Tribune -- Business)
Glenmark eyeing small buyouts Dec 17, 2007
The therapeutic areas which we focus on are inflammation (asthma, COPD and pain); metabolic disorders (diabetes and obesity) and dermatology. In the domestic market, we are very strong in dermatology, respiratory and pain management. (India Times, India -- Intl Business)
Doctors praising cord blood alternative Dec 16, 2007
DURHAM Children born with inherited metabolic disorders that cause organ failure and early death can be treated successfully with umbilical cord blood transplants from unrelated donors and, in some cases, go on to live for many years, according to a study led by Duke University Medical Center researchers. . (Herald Sun)
Umbilical cord blood can save babies Dec 13, 2007
WASHINGTON: Umbilical cord blood transplants, even from unrelated donors, can help save the lives of babies born with certain inherited metabolic disorders, US researchers reported on Monday ... Dr Vinod Prasad and colleagues at Duke University in North Carolina studied 159 children with inherited metabolic disorders who received transplants of cord blood from unrelated newborns at Duke between 1995 and 2007. (India Times, India -- Health/Science)
Cord Blood Viable Option For Kids With Life-threatening Metabolic Disorders Dec 12, 2007
11, 2007) Children born with inherited metabolic disorders that cause organ failure and early death can be treated successfully with umbilical cord blood transplants from unrelated donors and, in some cases go on to live for many years, according to a study led by Duke University Medical Center researchers ... For this study, researchers looked at 159 children with inherited metabolic disorders who received unrelated cord blood transplants at Duke between 1995 and 2007 ... "Patients with... (Science Daily)
Unrelated Cord Blood Helps Infants with Metabolic Disorders Dec 12, 2007
MONDAY, Dec. 10 (HealthDay News) -- Umbilical cord transplants from unrelated donors can benefit infants born with life-threatening metabolic disorders such as Hurler disease and Krabbe leukodystrophy, according to a study led by Duke University Medical Center researchers. These kinds of metabolic disorders -- which cause organ failure and early death -- occur in about one in 10,000 births ... This study included 159 children with inherited metabolic disorders who received unrelated donor cord... (MEDLINEplus)
Roche's Colorado boss leaving for Switzerland Dec 8, 2007
Roche specializes in in-vitro diagnostics and drugs for cancer and transplantation and is active in other therapeutic areas covering autoimmune diseases, inflammation, metabolic disorders and diseases of the central nervous system. Related Industry News. (Denver Business Journal, CO)
Adobe lays off workers at its S.D. office Dec 6, 2007
The inappropriate absence or presence of specific microRNAs in various cells has been shown to be associated with human diseases including cancer, viral infection and metabolic disorders. Sponsored Links. (San Diego Union-Tribune -- Business)
Pediatric specialty group looks after region's kids Dec 1, 2007
Hannah had a half-hour visit with Dr. Muslim Jami to talk about her "failure to thrive," which can be linked to acid reflux, infections, metabolic disorders or food intolerances. She will have to see the doctor again, but at least the follow-up exams can be done close to home. (Modesto Bee, CA)
What causes hiccups? Nov 30, 2007
Hiccups can also arise from a variety of neurological lesions, many of them involving the brain stem, or some metabolic disorders (particularly renal failure). Medications, often ones that promote acid reflux into the esophagus, and a variety of other disorders have also been linked to hiccups. (Scientific American)
African-American Men Face Disadvantages Versus Caucasian Men In Prostate Cancer Survival Nov 29, 2007
"Diabetes and metabolic disturbances associated with insulin regulation are more common among African-Americans compared to Caucasians, and metabolic disorders associated with obesity and diabetes may lower PSA levels and may cause a delay in referring a patient for a biopsy," Fowke said ... Given the increasing rates of obesity and diabetes among African-Americans, Fowke and his colleagues sought a better understanding of the relationship between race, metabolic disorders and PSA levels used to... (Science Daily)
Mechanism Explains Biological 'Cross-talk' Between 24-hour Body Cycle And Metabolism Nov 20, 2007
Many studies, including this one, point to a link between the human internal clock and such metabolic disorders as obesity and diabetes. Proteins such as Rev-erb are the gears of the clock and understanding their role is important for fighting these diseases. (Science Daily)
Youthful Binge Drinking Has Lasting Consequences Nov 20, 2007
New research into lifelong alcohol consumption reveals that heavy binge drinking by adolescents and young adults is associated with increased long-term risk for heart disease, high blood pressure, type 2 diabetes, and other metabolic disorders. The risk is lower in people who start drinking alcohol later in life and maintain more moderate drinking patterns. (Newsmax)
Tamiflu effective for treatment and prevention of influenza in children 1 year and older Nov 16, 2007
Roche is the world leader in in-vitro diagnostics and drugs for cancer and transplantation, a market leader in virology and active in other major therapeutic areas such as autoimmune diseases, inflammation, metabolic disorders and diseases of the central nervous system. . (EurekAlert!)
Cheek swab could help find bone-marrow donors Nov 6, 2007
Sun Special Features. " While bone-marrow-transplant medical professionals usually start looking for matches within families of patients, 70 per cent of the time, it is a stranger who provides the match that works. Dr. John Shepherd, a Vancouver Hospital hematologist and bone-marrow-transplant specialist, said the cheek-swab kits bring a true advantage over the former system because they are so easy and pain-free. "It's great that CBS is focusing efforts around ethnic diversity because there are... (Vancouver Sun)
