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News, Reviews, and Articles on Leukodystrophies
Stem cells 'halt nerve disease' Jun 5, 2008
Professor David Attwell, from University College London, said the study represented an "important proof of principle" that transplantation of these "precursor" cells could help restore myelin not only within people with leukodystrophies, but in theory within those affected by other conditions involving loss of myelin, such as multiple sclerosis, cerebral palsy and spinal cord injury. However, he said: "The work is still a long way from being applied in humans, and the paper raises several issues... (BBC News -- Health)
Stem Cells Improve Fatal Neurological Condition Jun 5, 2008
Thousands of children with rare, fatal disorders known as pediatric leukodystrophies share a central problem with the shiverer mice: Their brain cells lack sufficient myelin, a vital fatty coating that wraps around cells in the brain like insulation around an electrical wire. Myelin coats long sections, known as axons, of brain cells called neurons, and without it, the electrical signaling between neurons becomes sluggish and muddied, causing a variety of symptoms. (Science Daily)
* Lorenzos Oil child gave hope to thousands Jun 4, 2008
Adrenoleukodystrophy (ALD) is one of a group of genetic disorders called the leukodystrophies that cause damage to the myelin sheath, a membrane that surrounds nerve cells in the brain. Sufferers accumulate high levels of fatty acids in the brain and adrenal cortex because they do not produce the enzyme that breaks them down. (Taipei Times, Taiwan -- World)
Hope goes on Feb 16, 2006
Hunter's Hope Foundation, established by the Kellys after Hunter was diagnosed in 1997, has raised public awareness, as well as millions of dollars for research, into Krabbe and other leukodystrophies. "It's very humbling that you're all here," Jill Kelly told the hundreds of people gathered. (Buffalo News)
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