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    News, Reviews, and Articles on Interferon

    Archives: Interferon

    Helix Receives Approval to Open Sites in Germany for its Ongoing Clinical Trial With Topical Interferon Alpha-2b in Patients With Ano-Genital Warts  Sep 22, 2008
    AURORA, Ontario, Sept. 22 /CNW/ -- Helix BioPharma announced today that it has received the necessary regulatory approvals to open clinical sites in Germany to expand upon its clinical trial with Topical Interferon Alpha-2b in patients with ano-genital warts, which is presently underway in Sweden ... The trial is designed to assess the efficacy and safety of Topical Interferon Alpha-2b compared with placebo using a double blind, randomized design over an examination period of four months per... (Canada Newswire)

    Five-Year Data Confirm That Early Treatment with Betaseron(R) at First Sign of Disease Can Delay Progression to MS  Sep 21, 2008
    - BENEFIT is first and only prospectively planned 5-year study to show long lasting benefit of early treatment - MONTREAL, Sept. 20 /PRNewswire/ -- Bayer HealthCare Pharmaceuticals announced today that new data from its BENEFIT (BEtaseron in Newly Emerging multiple sclerosis For Initial Treatment) study confirm that early initiation of Betaseron(R) (interferon beta-1b) treatment in patients with a first event suggestive of multiple sclerosis (MS) significantly delayed the onset of... (PR Newswire)

    Merck Serono Announces Initiation of the ORACLE MS Trial to Evaluate Cladribine Tablets in Patients at Risk of Developing Multiple Sclerosis  Sep 18, 2008
    Cladribine is a small molecule that may interfere with the behavior and the proliferation of certain white blood cells, particularly lymphocytes, which are thought to be involved in the pathological process of MS. About Rebif(R) Rebif(R) (interferon beta-1a) is a disease-modifying drug used to treat relapsing forms of multiple sclerosis (MS) and is similar to the interferon beta protein produced by the human body ... Interferons are thought to help modulate the body's immune system and reduce... (PR Newswire)

    Three Rivers Pharmaceuticals(R), LLC Obtains Additional Commercial Rights to Infergen(R) from Amgen Inc.  Sep 17, 2008
    Infergen, or consensus interferon, is a unique, bio-optimized, selective and highly potent type 1 interferon alpha originally developed by Amgen and launched in the United States in 1997. Infergen is indicated for the treatment of chronic HCV infection in patients 18 years of age or older with compensated liver disease who have anti-HCV serum antibodies and /or the presence of HCV RNA. Important Safety Information Physicians and patients can obtain additional prescribing information regarding... (PR Newswire)

    Merck Serono Completes Enrollment in the REFLEX Trial of Rebif(R) in Patients at Risk of Developing Multiple Sclerosis  Sep 17, 2008
    This randomized, double-blind, placebo-controlled, international Phase III trial is designed to evaluate the therapeutic benefit of Rebif(R) (interferon beta-1a) on the time to conversion to multiple sclerosis (MS) in people with a first clinical event suggestive of the disease. "It has been demonstrated that treatment with interferon beta can reduce the risk of developing multiple sclerosis," said Anton Hoos, Executive Vice President, Global Development, Merck Serono ... About Rebif(R) Rebif(R)... (PR Newswire)

    Why Some SIV-Infected Primates Don't Get AIDS  Sep 17, 2008
    Feinberg's team found that in sooty mangabeys, dendritic cells produce much less interferon alpha--an alarm signal to the rest of the immune system--in response to SIV. As a result, the dendritic cells are not activated during the initial or chronic stages of SIV infection, and mangabeys fail to mount a significant immune response to the virus ... Mandl et al. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. (Science Daily)

    Marathoner finds running is the best medicine  Sep 13, 2008
    Then there are the days when she feels fatigued or has a negative reaction to her weekly interferon shot. The unpredictability is the hardest part, she said. (San Diego Union-Tribune)

    The IMF says journal editorial documents dramatic increase in survival since the 1980s  Sep 12, 2008
    "The benefits and comparisons are particularly interesting looking at the results with lenalidomide (Revlimid) plus low-dose dexamethasone (steroid) compared with prior results with interferon and levamisole. There is essentially a doubling of survival at two years, with preliminary evidence that this survival will be maintained for at least three to four years.". Dr. Durie notes these achievements with myeloma are now benefiting a wide range of blood cancers as these drugs are being tested in... (EurekAlert!)

    How do Lactobacilli treat Helicobacter pylori-related diseases?  Sep 10, 2008
    It was demonstrated that LBG-S had the same inhibitory effect on H. pyloriSS1-LPS-activated TLR4 signaling transduction as viable LBG. In a recent novel study, two soluble proteins with molecular sizes of 75 and 40 kDa were purified from supernatant recovered from Lactobacillus rhamnosus GG culture MRS broth and named p75 and p40 respectively, which ameliorated apoptosis of intestinal epithelia treated with tumor necrosis factor , interferon- or IL-1 and promoted cell growth through activating... (EurekAlert!)

    A potential approach to treatment of hepatitis B virus infection  Sep 10, 2008
    Interferon treatment is effective in only approximately one-third of the patients and produces considerable side effects. Long-term treatment with the second-generation nucleoside analogue lamivudine (lam) efficiently inhibits HBV replication with frequent viral polymerase mutations. (EurekAlert!)

    New approach, old drug show promise against hepatitis C, Stanford research shows  Sep 1, 2008
    The goal is to improve on the current treatment, a combination of the general antiviral drugs interferon and ribavirin. Those only work about half the time, but have uncomfortable, flulike side effects. (EurekAlert!)

    Viragen stock revoked  Aug 29, 2008
    It is a biopharmaceutical company that was engaged in the research, development, manufacture and sale of a human alpha interferon product for the treatment of infectious diseases. Viragen stock was traded on the until Nov. 19, 2007, when it was delisted for failing to maintain listing requirements. (South Florida Business Journal, FL)

    Respected medical journal says NICE 'needs a shake-up' and should ...  Aug 23, 2008
    Costing around 24,000 a year, Sutent can double the life expectancy of patients to 28 months compared with standard treatment with interferon. Kidney specialists are expected to appeal against the NICE decision. (Daily Mail)

    New insights into the regulation of PTEN tumor suppression function  Aug 21, 2008
    "Because PML is known to be 'druggable,' we believe that in cases of APL, modulation of PTEN function can be achieved with drugs already being used for the treatment of human cancers, including interferon and all trans-retinoic acid.". . (EurekAlert!)

    Elite woman may hold key to AIDS vaccine  Aug 13, 2008
    One thing the researchers have noticed is that while the husbands T-cells make just one, called gamma interferon, hers made both that one and another called TNF, or tumor necrosis factor. That cannot be the whole story, though, because AIDS researchers have tried using such immune system proteins in patients and they did not work well. (MSNBC -- Health)

    Early treatment is key to combating hepatitis C virus  Aug 9, 2008
    The only approved treatment for HCV is an anti-viral drug known as pegylated interferon alpha. This drug is successful in only half of cases when administered during chronic infection. (EurekAlert!)

    Row over NHS kidney drug decision  Aug 7, 2008
    Charities and some experts expressed outrage at the decision, saying it left patients only one treatment option - interferon - to which many do not respond. Professor John Wagstaff, from the South Wales Cancer Institute, said there was "no point" in him accepting referrals for people with advanced kidney cancer as around 75% of them "do not gain any real benefit" from interferon. (BBC News)

    What is the BFHI, why do we need it?  Aug 7, 2008
    Colostrum, which is considered mother's first milk, contains a high amount of immunoglobulins, antibodies, antioxidants, and interferon, which is known to be a potent antiviral (Walker, 2006). Formula feeding is associated with higher infant mortality rates in developing countries. (Nogales International, AZ)

    Despite risks, many staying with Tysabri  Aug 2, 2008
    For a time, doctors treated Cavallo with interferon and other drugs. But Cavallo said he developed a serious allergy to interferon. (Boston Globe)

    Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway  Jul 25, 2008
    "Thus our data," Dr. Zagon said, "brings a paradigm shift to our thinking about a drug widely used in the clinics. Rather than imiquimod activity being mediated by induction of various cytokines, including interferon (IFN)- , IFN- , tumor necrosis factor- (TNF ) interleukin (IL)-1 , and IL-12 as currently thought, an entirely new pathway - native to body chemistry - has been discovered to regulate cell proliferation by imidazoquinolines." Co-author, Moshe Rogosnitzky adds: "The elucidation of... (EurekAlert!)

    Primary Sensor That Detects Stomach Viruses Discovered  Jul 23, 2008
    MDA-5, and to a lesser extent, TLR3, respond by causing other cells to release interferon, which shuts down production of the virus and initiates a full-scale immune attack. MDA-5 and TLR3 are both intracellular proteins. (Science Daily)

    Improved Culture System For Hepatitis C Virus Infection  Jul 20, 2008
    Currently, there is only a single treatment for HCV, PEG- interferon. The drug combination has an average response rate of about 50 percent in HCV cases, but it is much lower than that, closer to 20 percent, in individuals with liver cirrhosis. (Science Daily)

    Biogen Idec issues Avonex warning  Jul 19, 2008
    Liver complications are associated with all of the beta interferon drugs, a class that includes Avonex. The FDA sees data from all the beta interferons," said Amy Ryan, the Biogen Idec spokeswoman. ''They're seeing increased hepatic injury and failure with all three products," she said, referring to Rebif and Berlex's Betaseron. (Yahoo News -- Multiple Sclerosis)

    Natalie Cole Lucky to Be Responding to Hep C Treatment,...  Jul 17, 2008
    The standard treatment for hepatitis C is weekly injections of a drug called pegylated interferon alpha, combined with twice-daily oral doses of ribavirin, according to the Mayo Clinic. It is curable, but not everyone can be cured, Rahimian said. (Fox News)

    New Study Sheds Light On How Intracellular Pathogens Trigger The Immune System  Jul 17, 2008
    The researchers isolated the role of multidrug resistance transporters by manipulating specific genes in the bacteria that controlled their expression and then measuring how increased or decreased activity by the transporter proteins impacted levels of interferon beta, a protein produced by the immune system that rally more disease-fighting cells when infections are detected. They found that greater MDR expression led to greater stimulation of the immune system, as measured by interferon beta... (Science Daily)

    Melanoma Drug Boosts Recurrence-Free Survival  Jul 15, 2008
    FRIDAY, July 11 (HealthDay News) -- A chemically modified form of interferon improves the chances that melanoma patients will survive and have no recurrence of the skin cancer, according to a new report ... "For the large group of patients with melanoma found in their sentinel node, we believe this regimen will be an attractive alternative to high-dose interferon. Some patients with macroscopic nodal disease who would not tolerate or accept high-dose interferon will also want to consider this... (MEDLINEplus)

    Nurses' Notes - Hepatitis C virus can damage liver and more  Jul 14, 2008
    Some types of chronic HCV infections may be treated with medications such as interferon and ribavirin. There are many side effects with these medications; they do not work for everyone and they are very expensive. (Missoulian, MT)

    Your Health: Mushrooms offer more than good taste  Jul 13, 2008
    Preliminary research suggests that the Shiitake may provide a number of benefits in the treatment of common viral infections, including influenza, hepatitis and AIDS. Extracts of the mushroom have been shown to trigger the production of interferon and other natural proteins that prevent viruses from multiplying in the body. In spite of being a low-calorie food, it s packed with key vitamins and minerals. (Green Valley News & Sun, AZ)

    Costly Vaccines Causing Deadly Dilemmas  Jul 13, 2008
    "Now, his liver is failing and he needs to be on an interferon medication called Pegasus, which hopefully will help the wear and tear on his liver. And without that, he will die," said Krull. When she reaches her insurance prescription limit, she will have to pay out-of-pocket nearly $6,000 a month for the expensive medication. (KIRO TV, WA)

    Best treatment for MS may depend on disease subtype  Jul 2, 2008
    Since the 1990s, the treatment picture has brightened for people with multiple sclerosis in its most common form, relapsing-remitting MS. Beta interferon drugs and glatiramer acetate (marketed as Copaxone) have proved effective at decreasing the attack rate and suppressing inflammatory plaque development in many patients with MS. Yet why the drugs help some patients, but not others, has remained a mystery ... "We already know that some people respond better to the drugs beta interferon or... (EurekAlert!)

    Potential Role Of Fish-based Fatty Acids In Resolving, Preventing Asthma  Jun 26, 2008
    Haworth et al. Resolvin E1 regulates interleukin 23, interferon- and lipoxin A4 to promote the resolution of allergic airway inflammation. Nature Immunology, 2008; DOI. (Science Daily)

    Promising trials for new MS pill  Jun 20, 2008
    Drugs available at the moment, such as glatiramer acetate and beta interferon, focus on the inflammation caused by the disease - a particular problem with the relapsing-remitting form - but they all have to be injected. Damage to brain. (BBC News -- Health)

    Same Drug, Different Results: Researchers On The Path To Personalized Medicine  Jun 20, 2008
    17, 2008) By comparing the DNA of patients with multiple sclerosis whose symptoms are reduced by interferon beta therapy to the DNA of those who continue to experience relapses, researchers may have identified. . (Science Daily)

    Rock 'n' roll cure  Jun 19, 2008
    There was talk of a transplant, but through a mixture of Interferon, Chinese herbs and acupuncture, he was nursed back to health within a few years. The inspiration and funding for his medical bills came from fellow musicians and industry people in the form of the benefit CD "Por Vida: A Tribute to the Songs of Alejandro Escovedo.". (Pittsburgh Post-Gazette, PA)

    Breakthrough In Understanding Tumor Immune Therapy: Induction Of Tumor Dormancy Instead Of Killing  Jun 16, 2008
    One of the important players that prevents the outgrowth of malignant tumors is interferon ... In the absence of either interferon or tumor necrosis factor the immune response converts the from a protective into a tumor promoting immune response ... In the case of an inappropriate cyto-kine pattern, i.e. missing interferon or missing tumor necrosis factor, the same response may dramatically enhance tumor growth. (Science Daily)

    EuroDYNA takes lid off the genome  Jun 14, 2008
    Pavel Kovarik from the University of Vienna's Department of Microbiology and Immunology noted that the only compound capable of alleviating MS symptoms was the protein interferon beta. This resembles the interferon produced naturally by the body in response to infection, but until now it has not been known how it relieves symptoms for MS sufferers ... However Kovarik and colleagues have shown that interferon works by upregulating (increasing production of) members of the protein family... (EurekAlert!)

    TB Treatment For Elderly Likely Requires Boost To Immune Response  Jun 13, 2008
    These CD4 T cells secrete a substance called interferon gamma, which activates the macrophage to help it kill the bacteria. If the immune response fails to prompt macrophages to kill the TB bacteria, the infected macrophages eventually burst and release TB bacteria into the lungs. (Science Daily)

    Beta Blocker May Shrink Infant Hemangiomas  Jun 13, 2008
    Other medications that can be used include vincristine (a chemotherapy medication) and interferon ... "Propranolol may constitute a reasonable, safe alternative to systemic corticosteroids, and even to interferon or vincristine in severe infant hemangioma. However, the risk/benefit ratio of this treatment should be evaluated in non-alarming, cosmetically impairing infant hemangiomas," Leaute-Labreze said. (MEDLINEplus)

    Helix BioPharma product development update, quarterly highlights and financial results for fiscal Q3 2008  Jun 12, 2008
    "We are currently developing plans for Topical Interferon to enter expanded Phase II/III clinical trials and we are anticipating L-DOS47 entering the clinic in a Phase I study." HIGHLIGHTS The Company's highlights for the quarter included the following events: Clinical Development - Helix met with the German Federal Institute for Drugs and Medical Devices (BfArM) as a preliminiary step toward filing its CTA for a planned large, randomized, placebo-controlled, double-blind Phase III European... (PR Newswire)

    Generex Biotechnology Presented Data At American Diabetes Association Scientific Sessions  Jun 9, 2008
    A significantly increased frequency of specific T cell responsiveness, as demonstrated by interferon gamma release, was observed using T cells from diabetics as compared to T cells from healthy volunteers using either the peptides or GAD protein. Release of another cytokine (IL10) was not significantly different between diabetics and healthy volunteers. (Primezone Releases)

    Drugs show success in the treatment of several cancers  Jun 3, 2008
    Sixteen patients with stage 4 disease who had not benefited from at least one round of prior therapy were treated with high-dose interferon alfa-2b and tremelimumab. The overall response rate was 19 percent. (Pittsburgh Post Gazette)

    New combination therapy safe, promising for melanoma patients  Jun 2, 2008
    High-dose interferon alfa-2b, a standard treatment for metastatic skin cancer, and tremelimumab, an antibody thought to instigate the bodys immune system to attack tumors, were combined for the first time in this phase 2 clinical trial. With each new study, we learn something important about melanoma, said John M. Kirkwood, M.D., leader of the program and professor and vice chairman for clinical research in the Department of Medicine, University of Pittsburgh School of Medicine. (EurekAlert!)

    About 60 Clinical Studies Regarding Schering-Plough's Oncology Compounds Will be Presented at ASCO  May 31, 2008
    Data will be presented on TEMODAR(R) (temozolomide) Capsules, CAELYX(R) (pegylated liposomal doxorubicin hydrochloride), INTRON(R) A (Interferon alfa-2b, recombinant) for Injection and peginterferon alfa-2b, as well as the company's investigational oncology compounds including SCH 727965 ... -- INTRON(R) A and peginterferon alfa-2b: Data will be featured in more than 10 abstracts, including five poster discussions and five oral presentations ... Please see important full U.S. Prescribing... (PR Newswire)

    Opposition to Malibu's proposed pot ordinance voiced  May 29, 2008
    "Conley Ulich said the City Council does not lean one way or other on the issue, and will wait to hear the final report from the Planning Commission and public commentary.Dustin Zahn, the proprietor of PCH Collective, grew up in Malibu and said he opened his dispensary because of personal family experience with medicinal marijuana."My mom was sick and went through a grueling treatment of interferon and other drugs," he said. "The only way she got through it was because she smoked [marijuana.... (Malibu Times, CA)

    UPDATE 1-Novartis' MS drug gets approval in EU  May 26, 2008
    Extavia is Novartis' branded version of Bayer AG's (BAYG.DE: , , ) Betaseron, interferon beta-1b, a first-line disease-modifying therapy injected every other day for the treatment of MS.. Novartis and Bayer settled a dispute over Betaseron in a deal that gave Bayer full control of the product while allowing Novartis to launch a version in 2009. (Reuters)

    Beach Boy'I didn't know how I got hepatitis C, but now I have beaten it'  May 24, 2008
    My treatment consisted of two antiviral drugs called Pegalayted Interferon and Riboviron. I took six pills a day and injected the interferon once a week for a year ... For example, time released interferon means that you can now have an injection once a week, instead of once a day, which makes it easier. (BBC News -- Health)

    Drug Fends Off Kidney Cancer Progression  May 21, 2008
    11, 2005) New research has shown that the immune-stimulating hormone known as interleukin-12 (IL-12) can safely be administered with interferon, another immune-system protein, as an experimental therapy for. (May 21, 2002) Researchers from the National Cancer Institute (NCI) reported today that the molecularly targeted drug bevacizumab slowed tumor growth in patients with metastatic renal cell carcinoma, the most. (Science Daily)

    Ernst focused on dream after battle with skin cancer  May 17, 2008
    As part of his treatment, he had to inject himself with interferon, which left him feeling like he constantly had the flu. The first month s treatment consisted of heavy dosage which left him with a fever of 103. (Boerne Star, TX)

    Your Health: Time for a coffee break? Try tea for your health  May 16, 2008
    Drinking tea increases production of interferon, a substance known to play a key role in protecting the body against infection. When researchers at Harvard Medical Center asked adult volunteers to drink five cups of black tea each day for four weeks, they found that their blood cells secreted five times more interferon than before they began drinking tea. (Green Valley News & Sun, AZ)

    When the environment can kill you  May 10, 2008
    The virus targets a patient's immunity by destroying a critical protein, Stat 1, found in a type of white blood cell that is responsible for the production of interferon, research by three research groups found. Interferon helps fight viruses and bacterial infections. (Palo Alto Online, CA)

    Grapefruit Compound Inhibits Hepatitis C Virus  May 6, 2008
    The current standard therapy of interferon and ribavirin is only effective in about 50 percent of cases and can cause major side effects, according to background information in the study. Recent research suggests that HVC may be "hitching a ride" along the lipoprotein life cycle, and that compounds and dietary supplements that influence lipoprotein metabolism may also affect HCV.. (Health-Finder)

    Anti-fibrotic Mechanism Of A Chinese Medicinal Herb May Inspire Drug Development  May 2, 2008
    These effects are different from those of Western antifibrogenic drugs (such as interferon- gamma). The authors explain that the herbs used to prepare Cpd 861 have been used for thousands of years in Traditional Chinese Medicine, and the results of this research could allow for the development of effective antifibrogenic drugs from Chinese medicinal herbs. (Science Daily)

    Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008  Apr 23, 2008
    "These new studies confirm earlier data suggesting synergistic activity between nitazoxanide and peginterferon in genotype 4 patients and provide a first look at sustained virologic response in a limited number of genotype 1 patients," said Jean-Francois Rossignol, M.D., Director of the Romark Institute for Medical Research and discoverer of nitazoxanide. "These data also provide interesting insights into the mechanism of action of nitazoxanide and confirm previous findings related to its... (PR Newswire)

    Health Disparities: Genetics Plays An Important Role In Cancer Detection, Prognosis Among Minorities  Apr 19, 2008
    Additionally, there was a distinctive interferon signature in gene over-expression in the African-American patients, which is associated with an immune system response against foreign invaders such as viruses. One puzzling finding: genes that activate the immune system and genes that suppress it were both more highly expressed in the African-American patients. (Science Daily)

    Pill Reduces Relapses in Multiple Sclerosis Patients  Apr 17, 2008
    "The first-line treatments for MS, beta interferon and glatiramer acetate, reduce the relapse rate by only about 30 percent, so this is a significant development for people with MS," Comi said in a statement. The most commonly reported side effects of FTY720 were headache, flu and cold symptoms. (MEDLINEplus)

    The Causes of Infection  Apr 16, 2008
    When a virus enters the cell it triggers the production of interferon: a substance which destroys many viruses. Major Micro-organisms Causing Infection. (Suite101.com)

    Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040  Apr 16, 2008
    The data showed that LOR-2040 significantly improved the anticancer efficacy of an important group of cytokine immunotherapeutic agents, including interferon alpha and interleukin-2, which have been used in the treatment of solid tumors. The findings expand the potential avenues for development of LOR-2040. (Canada Newswire)

    Skin cancer: 8-year-old faces grown-up battle  Apr 11, 2008
    Now, she is being treated with interferon shots, given by her mother, Missy Halverson ... The doctors say we're doing the interferon shots as a precaution. (The Clarion-Ledger)

    A time to heal - woman has wrestled with cancer  Apr 9, 2008
    Shortly after the diagnosis, she received intravenous treatments of interferon, a protein commonly used to treat hepatitis C. But what was supposed to be 20 days of treatment turned into two months. Her liver didn't react well to the treatment, and further treatments caused a blood clot. (Florida Times-Union)

    Mechanism Underlying Multidrug Resistance In Fungi Discovered  Apr 7, 2008
    3, 2007) Interferon, the "superhero" cure for viral infections, may be a strong weapon in the battle against fungal infections in immunocompromised patients, according to a new article. Fungal infections. (Science Daily)

    HILLARY BOMBSHELL ROCKS CAMPAIGN: 'OBAMA CAN'T WIN'  Apr 3, 2008
    Political Radar: Candidate Clinton to Richardson: 'Barack Obama Can't Win. Candidate Clinton to Richardson: 'Barack Obama Can't Win. (The Drudge Report)

    USC researchers find new clues to risk of Hodgkin lymphoma  Apr 2, 2008
    "We found that lower levels of the protein interleukin-12, involved in fighting intracellular infections, increases susceptibility to young adult Hodgkin lymphoma," says Wendy Cozen, D.O., M.P.H, associate professor of preventive medicine at the Keck School of Medicine of USC. " Cozen is lead author on the study entitled, "Interleukin-2, interleukin-12, and interferon- levels and risk of young adult Hodgkin lymphoma," published in the April 1 issue of the journal, Blood. The study is... (EurekAlert!)

    New Technique Will Speed The Development Of Vaccines, Study Shows  Mar 28, 2008
    In Brown s test, if the T cells recognized a protein, they started dividing and making interferon. Using the new procedure, Brown s team found T cells responded to about 20 proteins, including many that had never before been shown to stimulate a T cell response. (Science Daily)

    Former InterMune CEO W. Scott Harkonen Indicted for Wire Fraud and FDA Violations  Mar 19, 2008
    SAN FRANCISCO, March 18 /PRNewswire-USNewswire/ -- W. Scott Harkonen, M.D., the former CEO of InterMune Inc., was indicted on wire fraud and felony Food, Drug and Cosmetic Act charges for his role in the creation and dissemination of false and misleading information about the efficacy of InterMune's drug Actimmune (Interferon gamma-1b) as a treatment for idiopathic pulmonary fibrosis (IPF), the Justice Department announced today. The indictment alleges that Harkonen, a medical doctor, was the... (PR Newswire)

    Statement by InterMune, Inc. Regarding Justice Department Action Against Former Employee for Past Conduct  Mar 19, 2008
    March 18 /PRNewswire-FirstCall/ -- InterMune, Inc. (Nasdaq: ) issued the following statement regarding today's indictment of a former employee in connection with the promotional activities for Actimmune(R) (interferon gamma-1b) during a period that ended in June of 2003. "Today's indictment concerns conduct by a former employee who left the company more than four years ago. "In 2006, InterMune settled all government claims related to that conduct, without criminal sanctions against the company. (PR Newswire)

    Medgenics Consolidates Corporate and R&D Operations into New Office Facility  Mar 18, 2008
    INFRADURE producing interferon-alpha (IFN- ) to treat hepatitis C ... Other potential areas include multiple sclerosis (interferon- ), haemophilia (Factor XIII), paediatric growth hormone deficiency (human growth hormone) and diabetes (insulin). (BusinessWire)

    Scientists shine new light on inflammatory diseases  Mar 17, 2008
    In studies using human blood cells and mice, scientists examined the responses of macrophages during a two-day period after being stimulated with TNF. They found that macrophages secreted TNF and that then the TNF activated surface receptors on the macrophages themselves, spurring the cells into a low and sustained production of a protein called interferon-beta. This protein acted synergistically with TNF signals to induce 1) sustained expression of genes encoding inflammatory molecules and 2)... (EurekAlert!)

    Health Department Gives Information on Hepatitis  Mar 9, 2008
    There is no treatment for acute Hepatitis B. Treatment of chronic Hepatitis B may involve medications such as the antiviral medication alpha interferon. Hepatitis B is prevented by using protective practices during sex and during contact with contaminated blood. (Missourian Publishing, MO)

    Gene That Can Block The Spread Of HIV Discovered  Mar 1, 2008
    Barr and his team also prevented cells from turning on TRIM22 - provoking an interesting phenomenon: the normal response of interferon, a protein that co-ordinates attacks against viral infections, became useless at blocking HIV infection. "This means that TRIM22 is an essential part of our body's ability to fight off HIV. The results are very exciting because they show that our bodies have a gene that is capable of stopping the spread of HIV.". (Science Daily)

    Everolimus (RAD001) Significantly Extends Progression-Free Survival in Advanced Kidney Cancer Patients After Failure of Other Targeted Therapy  Feb 28, 2008
    In addition, prior therapy with Avastin(R) (bevacizumab)(3) and interferon was allowed. "Everolimus has the potential to greatly help patients with kidney cancer, especially in advanced stage who up to now have had no treatment options, as patients in the clinical trial on everolimus experienced a significantly longer period of time during which their cancer did not progress," said Daniel Vasella, Chairman and CEO of Novartis. (PR Newswire)

    Gene At Intersection Of Stem Cells, Immunity  Feb 27, 2008
    When Dr. Margaret Goodell, professor of pediatrics and director of BCM's Stem Cells and Regeneration (STaR) Center, and her colleagues infected mice that lacked the gene interferon-inducible GTPase Lrg-47 with a bacteria akin to tuberculosis, they found that stem cells did not initiate the process of making blood cells to protect against the infection ... "What was surprising was that this gene was regulated by interferon gamma," she said ... Finding the interferon-inducible GTPase Lrg-47 in... (Science Daily)

    First Chikungunya Animal Model Created  Feb 24, 2008
    tien F, Schilte C, Disson O, Brigitte M, et al. (2008) A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog 4(2): e29. (Science Daily)

    Probiotic Cuts Respiratory Illness Rates In Endurance Athletes, Study Suggests  Feb 21, 2008
    The probiotic treatment doubled levels of interferon gamma, an important component of the body s immune response. Probiotics seem to increase systemic immunity, possibly by boosting the activity of T cells, say the researchers. (Science Daily)

    Biogen Idec issues Avonex warning  Feb 21, 2008
    Liver complications are associated with all of the beta interferon drugs, a class that includes Avonex. The FDA sees data from all the beta interferons," said Amy Ryan, the Biogen Idec spokeswoman. ''They're seeing increased hepatic injury and failure with all three products," she said, referring to Rebif and Berlex's Betaseron. (Yahoo News -- Multiple Sclerosis)

    Support group provides hope for MS victims  Feb 20, 2008
    But my early interferon treatment has helped keep my MS under control and reduces the progression of the disease," she said. For Brown, the most difficult aspect of the disease is the occasional experience of not being able to complete simple functions. "At times, I am unable to walk or see," she said. "However, some people do not believe I have anything wrong with me. " In January 2005, Brown discovered an opportunity to meet and build relationships with others who share her experience when a... (Athens Banner-Herald)

    Researchers create first chikungunya animal model  Feb 20, 2008
    CITATION: Couderc T, Chretien F, Schilte C, Disson O, Brigitte M, et al. (2008) A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog 4(2): e29. (EurekAlert!)

    Experimental HIV Vaccine Gets A Boost From '70s-era Discovery  Feb 18, 2008
    Decades ago, poly-IC had been found to induce a potent immune-simulating chemical called interferon, leading researchers to believe it might work as a stand-alone therapy for infections and cancer. As a primary therapy, it never lived up to its potential and quickly fell out of view. (Science Daily)

    skewers the Fanjuls.  Feb 17, 2008
    "I got it in a transfusion in 1976," he says, "and I've been in the care of the Mayo Clinic since. The virus count went up last year, and I was being treated with interferon. But the cure is worse than the damn disease. So I quit, but I was told to stay away from crowds.". When charities hosted parties at his Palm Beach mansion recently, Montgomery was nowhere to be seen. (The Palm Beach Post)

    Virus immunity 'created in lab'  Feb 15, 2008
    It works by stimulating production of the protein interferon, the cell's first line of defence against viruses ... The researchers knocked out two key genes in mice that repress production of interferon ... With these genes out of action, the mouse cells produced much higher levels of interferon, which effectively blocked viruses from reproducing. (BBC News -- Health)

    Genetic Breakthrough Supercharges Immunity To Flu And Other Viruses  Feb 15, 2008
    Their process -- which could lead to the development of new anti-viral therapies in humans -- involved knocking out two genes in mice that repress production of the protein interferon, the cell's first line of defence against viruses. Without these repressor genes, the mouse cells produced much higher levels of interferon, which effectively blocked viruses from reproducing ... Interferon, in particular the type 1 interferons (IFN-; and IFN-2) suppress virus propagation. (Science Daily)

    Good bugs ward off flu in elite athletes  Feb 14, 2008
    Dr Pyne said the probiotic treatment, sold in Australia as Probiomics PCC, also doubled levels of interferon gamma, an important component of the body's immune response. "This is an encouraging clinical outcome but we are still exploring the mechanisms to explain this," he said. (Sydney Morning Herald)

    Probiotics 'protect top athletes'  Feb 14, 2008
    Blood tests taken from the athletes found doubled levels of interferon gamma, a chemical involved in the body's immune system, suggesting that the probiotics might somehow be helping the body to protect itself. The researchers said that the reason behind the study was to find ways to maximise the benefits to athletes getting ready for major events. (BBC News -- Health)

    Biological Factors That May Drive Prostate Tumor Aggressiveness In African-American Men Found  Feb 13, 2008
    In addition, expression of a number of genes that are induced by a cytokine called interferon was found to be elevated in the African-American prostate tumor tissues. Interferon is produced by cells in response to various pathogens, including viruses. (Science Daily)

    Silymarin does not affect virus activity or ALT levels in  Feb 2, 2008
    This information was somewhat surprising because these were patients with advanced liver disease who were clearly committed to conventional antiviral treatment for chronic hepatitis C, having been so treated previously, some on more than one occasion, but because they had failed to respond, were now willing to accept treatment again with pegylated interferon for another 3 and a half years ... The current recommended treatment for patients with HCV infection is combination therapy with pegylated... (EurekAlert!)

    Vertexs lead drug telaprevir for the treatment of Hepatitis C will have to be monitored for the potential emergence of drug resistance, physicians say  Feb 1, 2008
    In Genotype 4 patients, the drug reported an impressive 79% SVR rate in interferon-naive patients ... Dr Roger Pomerantz, president of Tibotec Research and Development, who previously chaired the FDA panel for anti-virals, said the main goal is the decrease the treatment time patients are on interferon and ribavirin. (FT.com -- Markets)

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