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    News, Reviews, and Articles on Insulin Resistance

    Archives: Insulin Resistance

    Link Between Obesity, Type 2 Diabetes And Neurodegeneration Found  Sep 6, 2008
    De la Monte says, "In essence, the brain shrinks and several biochemical and molecular abnormalities found in patients with AD, including brain insulin resistance, develop with chronic obesity and T2DM. However, the extent of the abnormalities in no way matches AD." Researchers note that the neuropathological abnormalities were mild and the associated brain insulin resistance could serve as a co-factor in the development and progression of AD.. Overall, the study found that that the effects of... (Science Daily)

    Normal ALT levels may mask advanced fibrosis in liver disease patients  Sep 5, 2008
    Article: "Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes." Fracanzani, Anna Ludovica; Valenti, Luca; Bugianesi, Elisabetta; Andreoletti, Marco; Colli, Agostino; Vanni, Ester; Bertelli, Cristina; Fatta, Erika; Bignamini, Daniela; Marchesini, Giulio; Fargion, Silvia. Hepatology ; September 2008; 10. (EurekAlert!)

    Focal Adhesion Kinase contributes to insulin-induced actin reorganization into a mesh harboring Glucose transporter-4 in insulin resistant skeletal muscle cells  Sep 5, 2008
    Focal Adhesion Kinase (FAK) is recently reported to regulate insulin resistance by regulating glucose uptake in C2C12 skeletal muscle cells ... Therefore, we investigated whether FAK contributes to insulin-induced actin remodeling and harbor Glut-4 for glucose transport and whether downregulation of FAK affects the remodeling and causes insulin resistance ... On the other hand FAK silencing reduced actin remodeling affecting Glut-4 translocation resulting into insulin resistance. (BioMed Central)

    Study Says Fat Cells in Obese Are Dysfunctional  Sep 2, 2008
    Study author Guenther Boden, who is the Laura H. Carnell Professor of Medicine and chief of endocrinology said fat cells in obese people had extra stress on the endoplasmic reticulum (ER), which in turn released proteins that hike insulin resistance. Dr Boden added the study may help explain why obese individuals are more prone to develop diabetes, heart disease, and stroke. (News Locale)

    Risks and benefits of antipsychotics in children and adolescents  Sep 2, 2008
    Weight gain in children raises the concern that, if treated for long periods, these patients may be at higher risk of insulin resistance, diabetes, hypertension, and cardiovascular disease in the future. If drugs likely to induce weight gain must be used, compensatory behavioural or pharmacological approaches should be implemented (Laita et al. 2007; Correll, 2007). (EurekAlert!)

    Know the Symptoms of Polycystic Ova...  Sep 1, 2008
    Insulin resistance or diabetes ... Patients with insulin resistance may be treated with insulin-sensitizing agents, such as Metformin. (Suite101.com)

    Not All Fat Is Created Equal: Fat In Obese Patients Is 'Sick' Compared To Fat From Lean Patients  Aug 30, 2008
    The stress that Boden describes causes the ER in fat cells to produce several proteins that ultimately lead to insulin resistance, which has been found to play a major role in the development and progression of obesity-related conditions ... Reducing weight can help reduce stress on the ER, which can lower the risk of insulin resistance and the resulting conditions ... High levels of blood glucose are associated with insulin resistance, which Boden believes could explain the link between obesity... (Science Daily)

    Fat cells of obese person are sick as compared to fat cells of ...  Aug 30, 2008
    When the ER is stressed, it produces several proteins that ultimately lead to insulin resistance. Insulin resistance, in turn, plays a major role in the development of obesity-related conditions. (TopNews)

    "Sick" Fat Found In Obese People  Aug 29, 2008
    This stress appears to lead to the production of specific proteins associated with insulin resistance, which plays a major role in obesity-related diabetes, says lead researcher Guenther Boden, MD. ... Boden says the findings could explain why diabetic people who have weight loss surgery often show dramatic improvements in insulin resistance within days of surgery, long before significant weight loss occurs ... Endocrinologist and diabetes researcher R. Paul Robertson, MD, tells WebMD that the... (CBS News)

    Dietitian Magician: Beer benefits pouring in  Aug 28, 2008
    Beer may be associated with lower levels of insulin resistance. Eventually, beer may prove to be as protective for keeping diabetes at bay as a glass of wine. (Ames Daily Tribune, IA)

    Secret to a healthy, long life: Good genes, better exercise  Aug 27, 2008
    Another age-related concern is cognitive decline, which is more likely in people with metabolic syndrome, a cluster of modifiable risk factors that includes abdominal obesity, high blood pressure, insulin resistance and abnormal cholesterol levels. Hall cautioned against therapeutic nihilism in treating older people with such risk factors. (International Herald Tribune -- Health)

    Are You an Apple or Pear?  Aug 21, 2008
    In men, the low testosterone levels that sometimes occur in 50s and 60s can increase the risk for heart disease, pre-diabetes, and insulin resistance, McLaughlin said. During this time, we also see an increase in abdominal fat. (Fox News)

    Study Identifies Protein That Produces 'Good' Fat: Finding May Lead To Ways To Treat, Prevent Obesity  Aug 21, 2008
    Tseng noted that obesity is a major risk factor for type 2 diabetes and is closely linked to the metabolic syndrome, a collection of medical problems associated with insulin resistance that can lead to an increased risk of atherosclerosis, the buildup of plaque in coronary arteries that leads to heart attack and stroke. In laboratory studies of mouse cells, Tseng and her colleagues identified that a bone-inducing protein called BMP-7 drives precursor cells that give rise to mature brown fat... (Science Daily)

    Top projects show where research cash goes  Aug 21, 2008
    Professor James heads a team at the Garvan whose research into insulin resistance has included investigation of traditional Chinese medicines used for centuries to treat diabetes. But he says research has much further to go to understand the complex links between diet, lifestyle and individual metabolisms which all have a role in diabetes. (Sydney Morning Herald -- Australia)

    Preeclampsia — A Glimpse into the Future?  Aug 21, 2008
    1 Although several risk factors for this condition are well recognized, including nulliparity, extremes of maternal age, obesity, and preexisting diabetes or hypertension, the causes of preeclampsia remain uncertain; recent studies have suggested that circulating angiogenic factors, alterations in the renin angiotensin system, and insulin resistance may be involved in pathogenesis. 1 Despite several trials examining various interventions,1 no strategy has proved effective in the prevention or... (New England Journal of Medicine)

    Knowing Food's Glycemic Effect  Aug 19, 2008
    The glycemic index is recognized as a key dietary consideration to control blood sugar levels, reduce insulin resistance and diabetes risk, and other inflammatory conditi ... High blood sugar after eating greatly increases your risk of insulin resistance and type 2 diabetes ... When blood sugar remains high because of insulin resistance, your pancreas just keeps making more and more insulin. (Suite101.com)

    Are you obese?  Aug 19, 2008
    Medical conditions various medical conditions, such as hypothyroidism, insulin resistance, polycystic ovary syndrome and Cushing's syndrome, are associated with abnormal weight gain. Childhood weight being mildly overweight during older childhood and you teenage years makes you statistically more likely to develop obesity as an adult. (iAfrica.com)

    Being obese doesn't mean you're not heart-healthy  Aug 14, 2008
    Carrying excess body fat around your abdomen - measured by your waist circumference - is associated with metabolic risk factors such as high blood pressure, low HDL cholesterol, high blood triglycerides and insulin resistance, a condition that occurs when your cells can't properly use the blood-sugar-clearing hormone insulin. (Insulin resistance is thought to be a precursor to Type 2 diabetes ... Waist circumference is a good measure of visceral fat, the type of deep fat that packs itself around... (Globe and Mail)

    > The Pitch: Prevendia's test helps spot insulin resistance  Aug 14, 2008
    Prevendia's test helps spot insulin resistance - Silicon Valley / San Jose Business Journal ... Prevendia's test helps spot insulin resistance ... What it does: is a medical diagnostic company that determines a person's insulin resistance by analyzing a small blood sample and delivering a report to the physician. (San Jose Business Journal, CA)

    Levels Of C-reactive Protein In The Blood Do Not Cause Diabetes  Aug 13, 2008
    Brunner et al. Inflammation, Insulin Resistance, and Diabetes Mendelian Randomization Using CRP Haplotypes Points Upstream. PLoS Medicine, 2008; 5 (8): e155 DOI. (Science Daily)

    Some Obese Individuals Appear 'Metabolically Healthy,' Without Increased Cardiovascular Risk  Aug 13, 2008
    For instance, individuals with fat within the abdominal cavity estimated by measuring waist size appear to be at higher risk for insulin resistance (a pre-diabetic condition that occurs when the body fails to respond to the hormone insulin) and for having an unhealthy cardiovascular risk profile ... Insulin resistance was measured using an oral glucose tolerance test ... The individuals were then divided into four groups: normal weight, overweight, obese but still sensitive to insulin and obese... (Science Daily)

    Overweight Hispanic children at significant risk for pre-diabetes, according to new USC study  Aug 13, 2008
    Increased obesity has been identified as a major determinant of insulin resistance. Lower beta-cell function is a key component in the development of type 2 diabetes, as the cells are unable to produce enough insulin to adequately compensate for the insulin resistance ... "Persistence of Pre-Diabetes in Overweight and Obese Hispanic Children: Association With Progressive Insulin Resistance, Poor Beta-cell Function and Increasing Visceral Fat."Diabetes. (EurekAlert!)

    What is Polycystic Ovarian Syndrome  Aug 7, 2008
    Having roots in insulin resistance and hormonal imbalance, PCOS can cause irregular menstrual cycles, obesity, and infertility ... In the PCOS cycle insulin resistance makes the signals that are being broadcast by hormones difficult to receive, so the FSH is not received at the ovaries in time to start follicle production right away ... Some are caused by the poor blood sugar regulation from the insulin resistance, and some are caused by an abundance of androgens, such as testosterone due to the... (Suite101.com)

    Report: Insulin Resistance May Lead to Cancer  Aug 6, 2008
    More recently, however, he was diagnosed with Type II diabetes, a problem that often starts with insulin resistance. Cardiac Wellness Nurse Scheri Miller said, Insulin Resistance is when the cell is unable to take up insulin from the bloodstream, so it becomes resistant to pulling glucose out and into the muscle cells to be used ... A new report in Environmental Nutrition says some of the most common cancers have now been linked to insulin resistance, which is why it's important for all of us... (WOKR13 Rochester)

    A Mechanism For The Development Of Obesity-associated Conditions  Aug 6, 2008
    They have been implicated in the development of many effects of a high-fat diet, including many risk factors for type 2 diabetes: obesity, insulin resistance, leptin resistance, and dyslipidemia ... However, they exhibited less severe insulin resistance, leptin resistance, and dyslipidemia than the normal mice. (Science Daily)

    Growth Hormone Reduces Fat In HIV Patients With Abdominal Obesity  Aug 4, 2008
    Therefore, the therapeutic window to achieve an optimal risk-benefit ratio of GH in individuals with HIV, abdominal fat accumulation, and insulin resistance may be very narrow and difficult to achieve ... In addition, strategies using diet, exercise, and lifestyle change may be more cost-effective in the long run than GH, particularly in patients with HIV, visceral adiposity, and insulin resistance, in whom changes in glucose may be counterproductive. (Medical News Today)

    Growth hormone treatment for HIV patients improves abdominal fat, but worsens glucose level  Aug 4, 2008
    Patients with HIV infection treated with antiretroviral therapy frequently develop changes in body composition, such as abdominal obesity, and metabolic complications of dyslipidemia (disorders of lipoprotein metabolism, including high cholesterol levels) and insulin resistance, putting these patients at increased cardiovascular risk ... "Low-dose physiological GH is well-tolerated and results in significant but more modest reduction in visceral adipose tissue [VAT; abdominal fat], but is... (EurekAlert!)

    Growth hormone reduces abdominal fat, cardiovascular risk in HIV patients on antiviral therapy  Aug 4, 2008
    A significant number of HIV-infected individuals receiving antiviral therapy develop lipodystrophy symptoms of which include excess fat deposits in the abdomen, a loss of subcutaneous fat in the face and extremities, increases in cholesterol and other blood lipids, and insulin resistance. Previous research has shown that growth hormone secretion is reduced in substantial number of those with the syndrome. (EurekAlert!)

    Metabolonsets sightson $20 million  Aug 1, 2008
    The pre-diabetes test Metabolon is developing would test for insulin resistance, a condition that is a strong indicator of type 2 diabetes ... Metabolon s insulin resistance test still needs clearance ... There, a research team headed by leading diabetes expert Dr. Ralph DeFronzo will work with Metabolon to search for biomarkers that signal insulin resistance. (Raleigh Triangle Business Journal, NC)

    Study Links Soft Drinks And Fruit Drinks With Risk For Diabetes In African-American Women  Jul 31, 2008
    6, 2007) Consumption of sugar-sweetened drinks, not including 100 percent fruit juice, may be associated with insulin resistance, even in otherwise healthy adults, according to nutritional. (Mar. (Science Daily)

    Exercise: It's an hour a day, people. Seriously.  Jul 30, 2008
    It's called Insulin Resistance Syndrome. And I've lost weight now that I'm on medication. (Los Angeles Times)

    Diet Key to Diabetes Risk  Jul 30, 2008
    "People who have a lot of beverages with high fructose corn syrup are not compensating by having fewer other calories, and it may not function to allow you to feel full, he said. "High fructose corn syrup may also cause liver problems and insulin resistance. " "At this point, all we can say is -- calories trump everything," he said. "All these high-density, empty calorie foods that are adding to the caloric load of the population and making it heavier are the real culprits. (MEDLINEplus)

    HIV Patients Living Longer  Jul 26, 2008
    "Longer life expectancies are shifting what has been the traditional portrait of AIDS, such as body-wasting along with numerous rare infections, into a condition that is increasingly associated with some of the manifestations we traditionally think of with older age, like cancers, heart disease, kidney and liver disease, and insulin resistance," Johnston said. However, Johnston thinks that many HIV patients continue to fall through the cracks. (MEDLINEplus)

    Regular Meals Reduce Risk Of Developing Metabolic Syndrome, Study Shows  Jul 24, 2008
    People who eat at irregular times run a greater risk of developing insulin resistance and what is known as metabolic syndrome, according to a study from the Swedish medical university Karolinska Institutet ... They also tended to exhibit more signs of insulin resistance, which is thought to be an underlying cause of metabolic syndrome. (Science Daily)

    Health Science Center diabetes researchers form partnership with N.C. firm  Jul 23, 2008
    Metabolon s global biochemical discovery platform will shed light on the biochemical changes related to increasing insulin resistance and beta cell dysfunction which contribute to the development of diabetes. Metabolon will analyze samples from various studies conducted by DeFronzo s team to determine which biochemical markers in patients demonstrate insulin resistance and beta cell dysfunction ... Insulin resistance is associated with people who are overweight, physically inactive or have some... (San Antonio Business Journal, TX)

    Alzheimers in a Can?  Jul 23, 2008
    They also developed insulin resistance and had a higher cholesterol count. When tested for mental function, the sugar-water mice scored lower on tests for memory retention and learning ability. (Newsmax)

    Walking Protects The Masai From Heart Disease  Jul 20, 2008
    (July 9, 2008) Dietary research in rats suggests that trans-fats do not increase the risk of insulin resistance and diabetes, which may ease at least one area of health concern for these. . (Science Daily)

    Can Diet Alone Control Type 2 Diabetes? No Evidence Yet  Jul 17, 2008
    In another study 12 months of dietary advice led to significant reductions in many diabetes related factors, such as insulin resistance, fasting C-peptide, fasting proinsulin, fasting blood glucose, fasting triglycerides, and fasting cholesterol and PAI-1. "These two studies give grounds for believing that dietary advice alone could play an important role in reducing type 2 diabetes, but we do need more well-designed, long-term studies before we can work out the best advice to give," says Nield. (Science Daily)

    Diabetes Could Be A Hidden Condition For Heart Disease Patients  Jul 16, 2008
    ScienceDaily (July 15, 2008) Researchers at the University of Warwick have discovered diabetes could be a hidden condition for some patients with coronary heart disease. In a study led by Dr Saverio Stranges, Associate Professor of Cardiovascular Epidemiology at Warwick Medical School, the team looked at levels of oxidative stress in the body (a toxic effect which causes cell damage). (Science Daily)

    Mitochondrial Cholesterol Makes Response To Chemotherapy Difficult In Hepatic Cancer  Jul 15, 2008
    The role of this decreased function in relation to insulin resistance and type 2. . (Science Daily)

    Trans-fatty Acids Do Not Appear To Increase The Risk Of Diabetes  Jul 13, 2008
    ScienceDaily (July 9, 2008) Trans-fatty acids have been the topic of a lot of negative health news, but a new dietary study in rats suggests that trans-fats do not increase the risk of insulin resistance and diabetes, which may ease at least one area of concern ... Epidemiological studies indicate that chronic consumption of trans-fats may alter muscle insulin sensitivity, as their unusual molecular shapes can reduce muscle's ability to burn energy; in turn, reduced fat oxidation may promote... (Science Daily)

    Why is a Balance of Omega-3 and Omega-6 Fatty Acids Good for Us?  Jul 13, 2008
    High levels of inflammation lead to vascular damage and insulin resistance. And this in turn leads to metabolic syndrome, type 2 diabetes and cardiovascular disease. (About - News & Issues)

    Metformin May Help Obese Teen Girls Lose Weight  Jul 13, 2008
    In the current study, researchers evaluated the effect of adding metformin versus placebo to a program of personal diet and exercise goal-setting for 85 obese adolescents with insulin resistance, a precursor to diabetes. Of the 85 subjects, 71 percent were female. (MEDLINEplus)

    Start your day with a square of chocolate  Jul 2, 2008
    What's more, research suggests that people who skip breakfast have a greater risk of becoming obese and developing insulin resistance. People who regularly eat breakfast are more inclined to follow a structured eating plan during the day and less likely to snack impulsively in the morning. (Globe and Mail -- Business)

    Exercise recommendations may not curb kids' weight  Jul 2, 2008
    The study also found that compared with their more sedentary peers, children who met the recommended activity levels had healthier numbers when it came to blood pressure, cholesterol, triglycerides and insulin resistance -- a precursor to type 2 diabetes. "We would certainly encourage children to be active, as our study showed that being active improved metabolic health even without improving BMI (body mass index)," lead researcher Dr. Brad S. Metcalf, of the Peninsula Medical School in... (Reuters)

    Call to rethink child BMI testing  Jul 1, 2008
    This, however, did not mean that the children meeting the target were no more healthy - blood testing revealed clear differences in the underlying metabolic signs of health - such as insulin resistance and cholesterol levels. Diet not exercise. (BBC News -- Health)

    Single Mechanism For Hypertension, Insulin Resistance And Immune Suppression  Jul 1, 2008
    nbein, a professor of bioengineering, describe how they successfully reversed the SHR animals' symptoms of high blood pressure, a pre-diabetes condition called insulin resistance, and immune suppression ... "The elegant study by Delano and Schmid-Sch?nbein points to a potentially very important overlap of an insulin resistance mechanism with hypertension in the spontaneously hypertensive rat (SHR).". (Science Daily)

    Children Still Not Getting Enough Physical Activity  Jul 1, 2008
    It may be that current guidelines are adequate, but the outcome measure used to monitor them (BMI) is too blunt. Second, girls undertake systematically less physical activity than boys, and it is unclear whether the guideline should be lowered for girls, to allow for what may be a biological difference, or particular encouragement given to girls to do more. (Medical News Today)

    Exercise won't cut childhood obesity  Jun 30, 2008
    Changes in weight and predictive health indicators, such as insulin resistance, blood fat and cholesterol levels, and blood pressure were measured annually between the ages of five and eight. Taken together, these health indicators reflect the risk of developing cardiovascular disease and diabetes. (Plymouth Evening Herald)

    A single mechanism for hypertension, insulin resistance and immune suppression  Jun 30, 2008
    Researchers identify the underlying molecular mechanism for hypertension, insulin resistance and other metabolic complications ... In a paper published June 30 in the online version of Hypertension, Frank DeLano, a research scientist at UC San Diego, and Geert Schmid-Schnbein, a professor of bioengineering, describe how they successfully reversed the SHR animals symptoms of high blood pressure, a pre-diabetes condition called insulin resistance, and immune suppression ... The elegant study by... (EurekAlert!)

    Is Southern food killing us?  Jun 28, 2008
    Another 57 million Americans may have prediabetes, elevated blood glucose levels that aren t high enough yet to net a diabetes diagnosis, but signal the insulin resistance that s a hallmark of the disease. When I looked at a U.S. map of diabetes cases on the CDC web site, I saw what I expected: Highest rates in the Southeast, which typically has the country s highest rates of obesity too. (Atlanta Journal-Constitution)

    Growth hormone's link to starvation may be clue to increasing life span, researchers find  Jun 28, 2008
    Too much growth hormone can cause insulin resistance, resulting in diabetes, and lead to other disorders. In the current study, mice that were genetically altered to produce excess FGF21 grew to be much smaller than ordinary mice, even though they ate more and had more fat in proportion to their size. (EurekAlert!)

    Preeclampsia Linked to Cardiovascular Problems After Pregnancy  Jun 26, 2008
    Insulin resistance increases and arteries malfunction years later, researchers say ... "We showed that this impairment is related to insulin sensitivity and also with waist-to-hip ratio," Kaaja said, "meaning that women with history of preeclampsia could be more sensitive to harmful effects of gaining weight and increased waist-hip ratio, leading to insulin resistance and increased risk for atherosclerosis." ... "Both factors, insulin resistance and impaired vasodilatation, lead to... (MEDLINEplus)

    Fatty liver the silent assassin  Jun 25, 2008
    Factors that can cause fatty liver include rapid weight gain, obesity, rapid weight loss (as seen in starvation), diabetes, insulin resistance, alcohol, high cholesterol, high triglycerides and certain medications ... If you have been diagnosed with diabetes or insulin resistance, it is important you take steps to manage your blood glucose levels. (Gold Coast News)

    Research links sugar and pancreatic cancer  Jun 24, 2008
    The researchers concluded: "High fructose and sucrose intakes may play a role in pancreatic cancer etiology. Conditions such as overweight or obesity in which a degree of insulin resistance may be present may also be important.". Sucrose, extracted from sugarcane and sugar beets, is commonly known as cane sugar. (Honolulu Star-Bulletin)

    Can grandma's remedy help reduce diabetes, obesity?  Jun 24, 2008
    They speculate that curcumin, the anti-inflammatory, anti-oxidant ingredient in turmeric, lessens insulin resistance and prevents Type 2 diabetes in these mouse models by dampening the inflammatory response provoked by obesity. Turmeric (Curcuma longa) has no known dose-limiting toxicities in doses of up to at least 12 grams daily in humans. (Sify.com, India)

    Why selling the Pill online could put women's health at risk  Jun 24, 2008
    For instance, women who have polycystic ovarian syndrome - a common condition where cysts f 00004000 orm on the ovaries - can also suffer from undetected insulin resistance. This can be aggravated by the Pill, increasing a woman's risk of developing Type 2 diabetes. (Daily Mail)

    Type II Diabetes: A Look at Vaspin  Jun 23, 2008
    A Probable Marker for Insulin Resistance. Many type II diabetics experience insulin resistance, a diminished response to the secretion of insulin by the pancreas ... Obesity is a known risk factor for type II diabetes and a majority of obese individuals develop insulin resistance- a lack of response to insulin that inhibits their cells' ability to absorb the sugar from their blood. (Suite101.com)

    Turmeric Prevents Diabetes in Mice Experiment  Jun 22, 2008
    They speculate that curcumin, the anti-inflammatory, anti-oxidant ingredient in turmeric, lessens insulin resistance and prevents Type 2 diabetes in these mouse models by dampening the inflammatory response provoked by obesity ... These cells produce "cytokine" molecules that can cause inflammation in organs such as the heart, and islets of the pancreas, while also increasing insulin resistance in muscle and liver. (MedIndia)

    Doctors offer to treat dying Winnipeg man after colleagues refuse  Jun 20, 2008
    Family's religious beliefs conflict with medical opinions. Samuel Golubchuk, 84, has been on life support with minimal brain function at the Grace Hospital since last fall. (CBC.ca)

    PET Scans Reveal Hormone Replacement Therapy May Be Beneficial For Postmenopausal Women  Jun 20, 2008
    According to Dr. Schindler, some of the factors putting women at risk are an accumulation of body fat, insulin resistance, inflammation, dyslipidemia (disruption of lipid metabolism) and increases in arterial blood pressure. Another important factor for postmenopausal women is the deprivation of naturally occurring estrogen. (Science Daily)

    Mothers Diet May Affect Daughters Puberty  Jun 19, 2008
    An early first menstrual period, before the age of 12, is a risk factor for breast cancer, teenage depression, obesity and insulin resistance ... An early first menstrual period, before the age of 12, is a risk factor for breast cancer, teenage depression, obesity and insulin resistance ... Ultimately, such children show much higher rates of insulin resistance, obesity and atherosclerosis than normal. (New York Times)

    Crackdown urged for docs who peddle HGH  Jun 19, 2008
    In fact, as Perls and Olshansky point out, the documented adverse effects include soft-tissue edema, arthralgias [joint pain], carpal tunnel-like syndrome, gynecomastia and insulin resistance with an elevated risk of developing diabetes. Not only has growth hormone not been approved for weight loss, or for anti-aging, but it. (MSNBC -- Terrorism)

    Gene Variants Linked To Metabolic Syndrome And HDL Cholesterol Levels  Jun 19, 2008
    18, 2003) Four hallmarks of the metabolic syndrome high blood pressure, high blood triglycerides, low blood HDL cholesterol and insulin resistance are independently and significantly linked to ... 14, 2008) Metabolic syndrome, a collection of related abnormalities like hypertension, obesity, insulin resistance, and excess cholesterol, poses a major risk for developing heart disease and diabetes. (Science Daily)

    Lifestyle can alter gene activity, lead to insulin resistance  Jun 19, 2008
    The findings suggest that lifestyle, more than heredity, contributes to insulin resistance in people who are obese. Insulin resistance increases the chance of developing diabetes and heart disease ... Recent studies have suggested that defects in expression of genes involved in the body's conversion of food to energy, known as mitochondrial oxidative phosphorylation, can lead to insulin resistance. (EurekAlert!)

    Age At Puberty Linked To Mother's Prenatal Diet  Jun 18, 2008
    An early first menstrual period, often used as a marker for early-onset puberty in girls is a risk factor for obesity, insulin resistance, teenage depression, and breast cancer in adulthood, said Deborah Sloboda, PhD, lead author of the study ... 17, 2008) In young girls at risk of early puberty and insulin resistance, the diabetes drug metformin delayed the onset of menstruation and decreased the development of insulin resistance, a risk factor for. (Science Daily)

    Diabetes Drug Slows Early-onset Puberty In Girls, Study Shows  Jun 18, 2008
    17, 2008) In young girls at risk of early puberty and insulin resistance, the diabetes drug metformin delayed the onset of menstruation and decreased the development of insulin resistance, a risk factor for type 2 diabetes, according to a new study ... Belly fat also is a marker of insulin resistance, in which the body needs more insulin than usual to clear glucose, or sugar, from the blood ... Therefore, Ibanez and her co-workers studied whether a low dose of metformin, a drug that improves... (Science Daily)

    Focus Attention Upon Distributors Of Human Growth Hormone, Scientists Urge  Jun 18, 2008
    However, documented adverse effects include soft tissue edema, arthralgias (joint pains), carpal tunnel-like syndrome, gynecomastia (enlarged breasts) and insulin resistance with an elevated risk of developing diabetes. Increasingly more and more animal and laboratory studies suggest an increased cancer risk. (Science Daily)

    FDA cracking down on fraudulent cancer products  Jun 18, 2008
    You're swallowing substances that reportedly can combat bronchitis, insulin resistance, stomach ulcers, high blood pressure, inflammation and aging. Mushrooms that are, according to VitaPurity's Web site, "reputed to be a tonic, a stimulant, an aphrodisiac and an aid in the prevention of cerebral hemmorhagic strokes.". (OregonLive, OR -- News)

    Diabetes Drug May Prevent Early Puberty in Young Girls  Jun 18, 2008
    Metformin delayed first menstruation, cut body fat for those at risk of insulin resistance ... TUESDAY, June 17 (HealthDay News) -- The diabetes drug metformin slows the onset of early puberty and reduces the risk of insulin resistance in girls at risk for both conditions, a Spanish study concludes ... That put them at increased risk for insulin resistance, a risk factor for type 2 diabetes, according to background information in the study. (Health-Finder)

    Insulin Resistance Tied to Peripheral Artery Disease  Jun 18, 2008
    MONDAY, June 16 (HealthDay News) -- A new study has found a strong association between insulin resistance and peripheral arterial disease (PAD), which leads to a four-to-five times increased risk of heart attack and stroke. People with the highest levels of insulin resistance (often a precursor to diabetes) had nearly twice as much PAD, regardless of other cardiovascular risk factors such as diabetes ... For each quartile of insulin resistance, the risk of PAD increased by about 25 percent. (MEDLINEplus)

    Daiichi-Ranbaxy: A transformational deal  Jun 16, 2008
    Troglitazone opened a new era as it was the first drug to address the problem of insulin resistance in patients suffering from type2 diabetes. Sales of this drug touched the billion-dollar mark, but it ran into problems with liver toxicity. (Economic Times)

    Unexpected Finding Of Molecule's Dual Role In Mice May Open New Avenue To Cholesterol Reduction  Jun 14, 2008
    14, 2008) Metabolic syndrome, a collection of related abnormalities like hypertension, obesity, insulin resistance, and excess cholesterol, poses a major risk for developing heart disease and diabetes. (Feb. (Science Daily)

    Belly Fat May Affect Liver Function  Jun 13, 2008
    "Our study found lipid release from abdominal fat was substantially elevated during the night, which may be a primary mechanism leading to insulin resistance, a strong risk factor for type 2 diabetes." ... "Further studies in this area should look at the cause of overnight elevation of abdominal fat release as well as clarifying the role this plays in the development of obesity and insulin resistance," suggests Harrison. (Science Daily)

    New KLRI Reports Shows Longevity Science Moving Beyond Studying the Obvious to the 'Downward Spiral' Paradigm in the Aging Process  Jun 11, 2008
    Finally, KLRI researchers are beginning to tease out the impact of diet on aging-related conditions such as insulin resistance, which is thought to contribute to a variety of diseases common in older people. The first study evaluated the anti-inflammatory effects of high levels of omega-3 fatty acids, "healthy" fats found primarily in fatty fish like salmon and tuna and in some seeds. (PR Newswire)

    InteKrin Therapeutics Presents Phase 2a Data at American Diabetes Association Meeting for INT131, a non-TZD SPPARM  Jun 9, 2008
    The changes in FPG were accompanied by significant improvements in insulin resistance and an increase in adiponectin, a key biomarker of PPAR-gamma mediated efficacy ... INT131 is well positioned to fulfill the unmet medical need for patients requiring safe treatment of insulin resistance, a key etiological feature in the onset and subsequent progression of T2DM, which remains inadequately addressed by current therapies. (PR Newswire)

    It helps kids at risk for Type 2 diabetes  Jun 7, 2008
    Still, most risk factors physical inactivity, a high proportion of body fat, high blood pressure and insulin resistance respond to changes in behavior. And because those risk factors intertwine, changes in one often spill over into another. (Harrisburg Daily Register, IL)

    Gum Care Helps Control Type 2 Diabetes and Its Complications  Jun 7, 2008
    Periodontal disease associated with higher levels of insulin resistance, studies say ... "We have found evidence that the severity of periodontal disease is associated with higher levels of insulin resistance, often a precursor of type 2 diabetes, as well as with higher levels of A1C," dentist Maria E. Ryan, director of clinical research at the Stony Brook University School of Dental Medicine in New York, said in a prepared statement ... A 1988-1994 U.S. population data study that found having... (Health-Finder)

    Researchers Discover Natural Inflammation-fighting Mechanism In Body-fat Cells  Jun 5, 2008
    Cellular stress caused by obesity, however, can override this protective function and convert the pathway into a trigger of chronic inflammation that raises the risk of insulin resistance, diabetes, and other metabolic disorders ... This signaling pathway serves as a natural counterbalance to a parallel signaling chain that promotes inflammation and can lead to insulin resistance -- a prelude to diabetes -- and other ailments such as heart disease, said the authors ... It may be possible, they... (Science Daily)

    Researchers ID Inflammation-Fighting Pathway in Fat Cells  Jun 4, 2008
    However, the researchers also found that obesity-related cellular stress can override the protective function and turn the pathway into a trigger of chronic inflammation, leading to increased risk of insulin resistance, diabetes and other metabolic disorders ... They said it may be possible to develop drugs designed to increase the protective effect to more strongly suppress inflammation and reduce the risk of insulin resistance, diabetes and other health problems. (Health-Finder)

    Men and Women May Metabolize Fructose Differently  Jun 4, 2008
    Short-term high fructose intake among young men resulted in increased blood triglycerides (fats) and decreased insulin resistance, factors associated with an elevated risk for cardiovascular disease and type 2 diabetes, report Dr. Luc Tappy and colleagues. Whereas, "women get rid of the excess sugar load in a (likely) less deleterious way," said Tappy, of Lausanne University School of Biology and Medicine in Switzerland. (MEDLINEplus)

    Metformin increases pathologic complete response rates in breast cancer patients with diabetes  Jun 3, 2008
    It's most often given to diabetic patients who are obese or have insulin resistance. The authors decided to conduct the research after a large, intriguing epidemiologic study published last year showed that patients with diabetes who took metformin had lower incidences of cancer as well as better outcomes. (EurekAlert!)

    AMT Announces Positive Interim Clinical Data on its Lead Product AMT-011  May 30, 2008
    As a result, LPL-deficient patients have very high fat (triglyceride) levels in their blood which may lead to recurrent episodes of pancreatitis, insulin resistance, and fat accumulations in skin as well as liver and retina ... In the two patients that had diabetes, a reduction of insulin resistance was observed, leading to a reduction of their diabetic medication. (PR Newswire)

    DWD: New Survey Shows Childhood Obesity Slowing  May 29, 2008
    He says there are clear links between insulin resistance, which leads to diabetes, and obesity. "So by losing weight, by having the society in general being skinnier, then the incidence of that initial insulin resistance will decrease. So the incidence of type 2 diabetes will decrease as well," said Dr. Dewan. (KLAS-TV.com, NV)

    Fruit Juice Consumption Not Related To Overweight In Children, Study Suggests  May 23, 2008
    6, 2007) Consumption of sugar-sweetened drinks, not including 100 percent fruit juice, may be associated with insulin resistance, even in otherwise healthy adults, according to nutritional. (Feb. (Science Daily)

    Archives: Insulin Resistance

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