CombiMatrix to Hold Conference Call to Discuss the Development of Array for Cancer Screening Oct 3, 2008
This technology has a wide range of potential applications in the areas of genomics, proteomics, biosensors, drug discovery, drug development, diagnostics, combinatorial chemistry, material sciences and nanotechnology. We have also developed the capabilities of producing arrays that utilize bacterial artificial chromosomes on our arrays, also enabling genetic analysis. (Primezone Releases)
CIO tackles complex security, patient privacy mandates Sep 25, 2008
We are just scratching the surface of what our capabilities will be, and with the new advances in genomics and proteomics and the new procedures that physicians are doing with new kinds of tools, like robotics and special kinds of scans, three-dimensional constructions of scans, it is just an exciting place to be ... We are just scratching the surface of what our capabilities will be, and with the new advances in genomics and proteomics and the new procedures that physicians are doing with new... (SearchCIO.com)
European Research Effort Tackles Dangerous Mould Sep 25, 2008
The ESF Research Networking Programme FUMINOMICS will tackle the basic questions surrounding gene expression and gene regulation of A. fumigatus through a multidisciplinary and fully integrated functional genomics approach that spans bioinformatics, transcriptomics, proteomics, physiology, molecular genetics and medicine. Adapted from materials provided by. (Science Daily)
Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health Sep 25, 2008
" He also emphasised that without the support of the Swiss government and international partners, none of this would be possible, "so we owe a big thanks to them", he added. In addition, Professor Bairoch thanked the Swiss government, international funding agencies and all the scientists who contributed to their recent breakthrough. He said, "ours is just one of the 25 SIB groups working at the frontiers of scientific knowledge for the benefit of mankind". ### About the SIB The Swiss Institute... (EurekAlert! -- Business News)
A list of the 2008 MacArthur Foundation fellows Sep 24, 2008
By using genetics, genomics, ecology and embryology, Mango researches how organs are formed. Diane Meier, 56, geriatrician, New York, New York. (USA Today)
American Journal of Gastroenterology Publishes Study of Advanced ... Sep 23, 2008
EXACT Sciences Corporation EXACT Sciences Corporation uses applied genomics to develop effective, patient-friendly screening technologies for use in the detection of cancer. EXACT maintains an exclusive license agreement with Laboratory Corporation of America(R) Holdings (LabCorp(R)) relating to the Company's intellectual property. (MarketWatch)
SFBR wins $18.8 million research grant to study cardiovascular disease Sep 23, 2008
The Southwest Foundation for Biomedical Research will employ its AT&T Genomics Computing Center to map out the genes. San Antonio-based SFBR is an independent biomedical research institution. (San Antonio Business Journal, TX)
Paolo Soleri to receive Celebration of Innovation lifetime achievement award Sep 23, 2008
William F. McWhortor Community Service Leader of the Year: Dr. Daniel D. Von Hoff, Translational Genomics Research Institute Clinical Research Services at Scottsdale Healthcare; Jeff Morhet, InNexus Biotechnology Inc.; and Terree Parlett Wasley, Arizona State University Technolpolis. Ed Denison Business Leader of the Year: Steve Irons, ImageTag Inc.; Roy Vallee, Avnet Inc.; and Jeff Morhet, InNexus Biotechnology Inc.. (Phoenix Business Journal, AZ)
2008 MacArthur "Genius" Grants Announced Sep 23, 2008
By using genetics, genomics, ecology and embryology, Mango. David Montgomery, 46, geomorphologist, Seattle, Wash. (CBS News -- US)
Google's Sergey Brin Starts Blog, Reveals Predisposition For ... Sep 22, 2008
Industry observers believe for the prospects of personal genomics companies. 23andMe had a near-death experience in June when the California Department of Public Health out to genetic testing services in the state demanding that the companies cease genetic testing until licensed to do so by the agency. (InformationWeek)
Presenting science questions to John McCain and Barack Obama Sep 20, 2008
In addition, concerned about the premature introduction of genetic testing into the public domain without appropriate oversight, I introduced the Genomics and Personalized Medicine Act of 2007, aimed at ensuring the safety and accuracy of such testing. Advances in the genetic engineering of plants have provided enormous benefits to American farmers. (Los Angeles Times)
Biologists Identify Genes Controlling Rhythmic Plant Growth Sep 20, 2008
"It was known that the circadian clock confers an adaptive advantage to plants in nature, and these findings provide a direct mechanism by which plants optimize their growth by synchronizing hormone signaling with the environment," said first-author Todd Michael, a former postdoctoral fellow at Salk who is now an assistant professor of genomics and bioinformatics at the Waksman Institute and Rutgers University. Other coauthors included UCSD postdoctoral fellows Ghislain Breton and Samuel Hazen,... (Science Daily)
Genetic Research Using Human Samples Requires New Types Of Informed Consent Sep 19, 2008
Mascalzoni D, Hicks A, Pramstaller P, Wjst M. Informed consent in the genomics era. PLoS Med, 2008; 5(9): e192 DOI. (Science Daily)
Bovine Mastitis: Could A Vaccine Be On The Way? Sep 18, 2008
The project is being conducted in collaboration with Dr Tracey Coffey s Bovine Genomics group based at IAH and other groups at the Royal Veterinary College, the US Department of Agriculture in the UK and the University of Oxford. Professor Leigh said: We will use state-of-the-art molecular technology to determine the differences between strains of S. uberis that can and cannot cause disease. (Science Daily)
Brain Protein Linked To Alzheimer's Disease Sep 17, 2008
16, 2008) Investigators at the Translational Genomics Research Institute (TGen) announced a link between the brain protein KIBRA and Alzheimer's disease, a discovery that could lead to promising new treatments for this memory-robbing disorder ... "This research suggests that KIBRA, and possibly some of the proteins with which it interacts, may play a role in Alzheimer's disease,'' said Dr. Matthew Huentelman, an investigator in TGen's Neurogenomics Division and the paper's senior author. The... (Science Daily)
Genetic Mutation That May Predict Organ Rejection Identified Sep 17, 2008
Study collaborators include Daniel E. Weeks, PhD, and associates from the Department of Human Genetics at the University of Pittsburgh, and Hakon Hakonarson, MD, from the Center for Applied Genomics at The Children's Hospital of Philadelphia. Adapted from materials provided by. (Science Daily)
More Findings On Gene Involved In Childhood Asthma Sep 17, 2008
D., director of the Center for Applied Genomics at Children's Hospital ... The researchers used highly automated gene-scanning equipment at Children's Hospital's Center for Applied Genomics, the largest pediatric genotyping program in the world. (Science Daily)
More biomedical spending reports needed Sep 17, 2008
The state's auditor general recommends that the biomedical commission revamp the way it collects and reports data about projects it funds for groups such as the Translational Genomics Research Institute (TGen), the state's universities and others ... 5 million each year, making the Phoenix-based genomics group the biomedical commission's largest funding recipient. (AZCentral -- Business)
Unique Bacterium Has Genes For Potent Biofuel Sep 16, 2008
"This was an excellent example of using proteomics to guide initial genomic annotation," said protein chemist Jon Jacobs of PNNL. "We're helping to set a precedent if we can do the proteomics work while they're doing the genomics work.". Overall, Cyanothece 51142 carries one large circular chromosome and four small chromosomes called plasmids, and the linear one. (Science Daily)
Faster, Cheaper Way Of Analyzing The Human Genome Developed Sep 16, 2008
15, 2008) Investigators at the Translational Genomics Research Institute (TGen) has recently announced a faster and less expensive way for scientists to find which genes might affect human health ... Dr. David Craig, associate director of TGen's Neurogenomics Division, said the new method should cost only one-tenth, or less, of the current cost of sequencing genes commonly done to analyze Single Nucleotide Polymorphisms (SNPs), and in performing Genome-Wide Association (GWA) studies. (Science Daily)
Ariz. research yields another Alzheimer's tie Sep 16, 2008
A research team spearheaded by the Translational Genomics Research Institute found that people with a version of the Kibra protein appear to have a 25 percent lower risk of developing Alzheimer's disease ... The discovery may yield a new target for scientists and pharmaceutical companies to attack with medications, said Matthew Huentelman, an investigator with TGen's neurogenomics division who led the study ... Eric Reiman, executive director of Banner Alzheimer's Institute and clinical director... (AZCentral -- Business)
Biodefense: Scientists take the offense to find funding Sep 16, 2008
"The idea is a great one," said Paul Keim, director of the pathogenic genomics division at the Translational Genomics Research Institute and director of the Center for Microbial Genetics and Genomics at Northern Arizona University. "If we had gotten that funded, we would be a lot closer to the point where we could do it.". (Phoenix Business Journal, AZ)
Translational Genomics advances gene scanning Sep 15, 2008
Now, the Translational Genomics Research Institute is among the research groups that are working on quicker and less expensive ways to perform targeted scans ... "How can we take this fire hose of power and control it in a way where we can look at a large number of people?" said David Craig, associate director of TGen's neurogenomics division. (AZCentral -- Business)
Arizona institutes play role in lung cancer research Sep 15, 2008
One component, to develop a diagnostic tool for lung cancer, will be led by the Partnership for Personalized Medicine, involving the Translational Genomics Research Center, the Biodesign Institute at Arizona State University and Dr. Lee Hartwell, president of the Fred Hutchinson Cancer Research Center in Seattle. TGen also will lead another component to create a human-specimen biorepository. (Phoenix Business Journal, AZ)
TGen investigators devise faster, cheaper way of analyzing the human genome Sep 15, 2008
Sept. 14, 2008 Investigators at the Translational Genomics Research Institute (TGen) today announced a faster and less expensive way for scientists to find which genes might affect human health ... Dr. David Craig, associate director of TGen's Neurogenomics Division, said the new method should cost only one-tenth, or less, of the current cost of sequencing genes commonly done to analyze Single Nucleotide Polymorphisms (SNPs), and in performing Genome-Wide Association (GWA) studies ... "Moving... (EurekAlert!)
NIH Funds SIGA Dengue Antiviral Program Sep 12, 2008
SIGA Technologies is applying viral and bacterial genomics and sophisticated computational modeling in the design and development of novel products for the prevention and treatment of serious infectious diseases, with an emphasis on products for biological warfare defense. SIGA believes that it is a leader in the development of pharmaceutical agents to fight potential bio-warfare pathogens. (Primezone Releases)
A map of the class III region of the sheep major histocompatibilty complex Sep 12, 2008
BMC Genomics 2008, 9:409doi:10. 1186/1471-2164-9-409. (BioMed Central)
High Levels Of Physical Activity Can Blunt Effect Of Obesity-related Gene, Study Suggests Sep 11, 2008
D., the lead author and a former postdoctoral fellow at the University of Maryland School of Medicine who is now at the University of Miami Institute for Human Genomics ... "We are just starting to unravel these complex interactions between genomics and environment. It's really a new age of discovery," Dr. Snitker says ... 15, 2008) Genomics researchers, seeking to replicate another group's discovery of an important gene associated with obesity, have further refined the signal to a particular... (Science Daily)
Casting call for YouTubers: $25k for green ideas Sep 11, 2008
The X Prize Foundation is behind the $10 million Archon X Prize for Genomics and the $30 million Google Lunar X Prize to build a moon vehicle that can surf over lunar rocks. The YouTube contest is one of its first smaller-scale contests to seed a larger challenge, but it fits in with a broader investment theme of the environment. (Yahoo News -- Technology)
Trichoplax Genome Sequenced: 'Rosetta Stone' For Understanding Evolution Sep 9, 2008
29, 2003) Researchers at The Institute for Genomic Research (TIGR) and The Center for the Advancement of Genomics (TCAG) have sequenced and analyzed 1 ... 5, 2005) A large group of scientists led by the Beijing Institute of Genomics is publishing a much improved, near-complete genome analysis of the indica and japonica subspecies of O. sativa, which are eaten. (Science Daily)
Structure Of Key Epigenetics Component Identified Sep 9, 2008
8, 2008) Scientists from the Structural Genomics Consortium (SGC) have determined the 3D structure of a key protein component involved in enabling "epigenetic code" to be copied accurately from cell to cell ... "Given the increasing focus on epigenetics as a mechanism behind cancer, elucidating the structure of UHRF1 may provide crucial insights into what goes wrong," says Professor Sirano Dhe-Paganon from the Structural Genomics Consortium laboratories at the University of Toronto, Canada. (Science Daily)
Senator Obama's Priorities - WashingtonWatch.com Sep 8, 2008
The statement of purpose for an Obama bill called S. 976, The Genomics and Personalized Medicine Act of 2007, makes some exaggerated claims about what it will do, winning it membership in WashingtonWatch. com's "And a Pony" club. (PR Newswire)
Stem cells from patients with genetic diseases Sep 7, 2008
PHG Foundation is the trading name of the Foundation for Genomics and Population Health, a charitable company registered in England and Wales Company Number: 5823194, Charity Number: 1118664. (PHG Foundation)
Researchers Pinpoint Genes Linked to Childhood Inflammatory Bowel Disease Sep 6, 2008
Because environmental exposures have not had time to impact IBD progression in children, researchers have a clearer genetic picture of the disease allowing them to pick out additional genes overlooked in adult research, says senior study author Hakon Hakonarson, director of the Center for Applied Genomics at The Children's Hospital of Philadelphia. Over 1,000 pediatric IBD patients of European ancestry were recruited for the study in the U.S. and Italy. (Scientific American)
DNA Editing Tool Flips Its Target Sep 6, 2008
3, 2008) Scientists from the Structural Genomics Consortium have determined the 3-D structure of a key protein component involved in enabling "epigenetic code" to be copied accurately from cell to cell. The. (Science Daily)
Massive Cancer Gene Search Finds Potential New Targets In Brain Tumors Sep 6, 2008
Chin is the scientific director of the Belfer Cancer Genomics Center in the Center for Applied Cancer Science at Dana-Farber, and Meyerson directs the Center for Cancer Genome Discovery at Dana-Farber. The research was funded by grants from the NIH.. (Science Daily)
Scientists ID 2 New Genes for Bowel Disease in Kids Sep 6, 2008
"As we better understand the complex gene interactions in IBD, we may be able to diagnose patients by their genetic profile to predict who will better respond to anti-TNF drugs," study leader Hakon Hakonarson, director of the Center for Applied Genomics at The Children's Hospital, said in the news release. More information. (U.S. News & World Report)
* Ho team makes H5N1 vaccines Sep 5, 2008
The team, led by David Ho (j@) of Rockefeller University and Wong Chi-huey (f) of Academia Sinicas Genomics Research Center, published the findings on Tuesday in the online edition of the Proceedings of the National Academy of Sciences ... After infection with the Indonesian strain of H5N1, 80 percent of the subject mice survived, said Rachel Cheng (G@) of the Genomics Research Center. (Taipei Times, Taiwan -- World)
Second Site For Prostate Cancer Gene Found Sep 5, 2008
Xu, a professor of epidemiology and cancer biology and Director of the Center for Cancer Genomics, reported the results with 30 colleagues in the current on-line version of Nature Genetics ... D., and S. Lilly Zheng, M.D., of the Center for Cancer Genomics and the Center for Human Genomics at Wake Forest, are co-first authors of the paper ... Additional co-authors from Wake Forest's cancer genomics and human genomics centers are Lina D. Purcell, M.S., Zhengrong Gao, B.S., Seong-Tae Kim, Ph. (Science Daily)
New clues found to treat brain cancer Sep 5, 2008
Scientists from 18 groups, including the International Genomics Consortium in downtown Phoenix, identified three new wayward gene mutations for patients with glioblastoma - the type of brain cancer that U.S. Sen. Edward Kennedy, D-Mass. (AZCentral -- Business)
Gene enhancer in evolution of human opposable thumb Sep 5, 2008
" ### The study, led by Drs Prabhakar and Noonan, was initiated in Dr Edward M. Rubin's lab at the Lawrence Berkeley National Laboratory (LBNL) and continued as collaboration between the three groups (Noonan, Prabhakar, and Rubin). Notes to editor: Research publication: The research findings are reported in the Sept. 4, 2008 issue of Science in a paper titled, "Human-Specific Gain of Function in a Developmental Enhancer". Authors: Shyam Prabhakar,1* Axel Visel,1 Jennifer A. Akiyama,1 Malak... (EurekAlert!)
New Endometrial Cancer Treatment Stops Growth Of Tumors And Kills Cancer Cells, Study Shows Sep 4, 2008
3, 2008) Researchers at the Translational Genomics Research Institute (TGen) today announced a new approach to treating endometrial cancer patients that not only stops the growth of tumors, but kills the cancer cells. See also. (Science Daily)
Early Onset Gene For Inflammatory Bowel Diseases Identified Sep 4, 2008
The study's senior author is Hakon Hakonarson, MD, director of the Center for Applied Genomics at Children's Hospital of Philadelphia and associate professor of pediatrics at University of Pennsylvania School of Medicine. Both genetics and the environment have an effect on the risk of getting inflammatory bowel disease, Kugathasan says. (Science Daily)
Major international study shows lowering heart rate lessens risk of heart attacks in patients with coronary artery disease and a heart rate above 70 beats per minute Sep 3, 2008
MHI researchers also contribute to the advancement of knowledge and medical applications in the fields of genomics (notably, genetics and pharmacogenomics), biomarkers, and preventive cardiology. To learn more about the Institute, please visit our website at www. (Canada Newswire)
Person's Geographic Origins Located From DNA Sep 3, 2008
The methodology has wide-ranging implications for using DNA samples from unrelated individuals to identify genes underlying complex diseases, as well as forensics, personalized genomics and the study of recent human history. Using data from a sample of almost 3,200 Europeans supplied by GlaxoSmithKline, the team analyzed more than 500,000 genetic points known as single nucleotide polymorphisms (SNPs), or minute sequence variations in DNA. The researchers focused its analysis on individuals for... (Science Daily)
2nd La Jolla research institute gets huge NIH grant Sep 3, 2008
and the NIH's Chemical Genomics Center in Bethesda, Md. That fact that two came from San Diego indicates the excellence of science that is found in California, Brady said. (San Diego Union-Tribune -- Business)
Innate immune system targets asthma-linked fungus for destruction Sep 3, 2008
Hirohito Kita added: "We have taken an important step in showing that the innate immune system of eosinophils is capable of targeting an asthma-associated fungus for destruction. The biological significance of these results will need to be verified further in animal models and in humans and our collaborative efforts with Dr. Lawrence's research group for proteomics and functional genomics will be invaluable in this respect. We suspect that the dysregulated immune responses to Alternaria, other... (EurekAlert!)
New Genes Found For Inflammatory Bowel Disease In Children Sep 2, 2008
D., director of the Center for Applied Genomics at Children's Hospital. "We strongly suspect one gene will provide a compelling target for drug development, given what's known about its biology.". (Science Daily)
New Field Of Research Could Help Police In Crime Scene Forensics Sep 2, 2008
1, 2008) A team of investigators led by scientists at the Translational Genomics Research Institute (TGen) have found a way to identify possible suspects at crime scenes using only a small amount of DNA, even if it is mixed with hundreds of other genetic fingerprints ... "This is a potentially revolutionary advance in the field of forensics,'' said the paper's senior author, Dr. David W. Craig, associate director of TGen's Neurogenomics Division, which otherwise is charged with finding ways to... (Science Daily)
DNA breakthrough can identify an individual in a public place Sep 1, 2008
The team, from the Translational Genomics Research Institute in Phoenix, Arizona, developed a mathematical technique to determine whether the DNA of an individual was present in a mixture. They tested their method successfully on a variety of samples they had mixed. (Times Online)
More Genes Are Controlled By Biological Clocks Than Previously Thought Sep 1, 2008
Computing Life will also allow researchers to design a sequence of genomics experiments that will winnow the field of competing hypotheses and to move experiments in directions where new discoveries are likely to arise. Biological clocks hold the key to much of life and disease processes. (Science Daily)
Valley's TGen has new way to attack tumors Sep 1, 2008
Researchers at the Translational Genomics Research Institute have developed a new treatment for endometrial cancer that they say could save thousands of female lives a year. The treatment not only blocks tumor growth but also kills endometrial cancer cells, which attack the lining of the uterus. (AZCentral -- News)
BioScience tip sheet, September 2008 Sep 1, 2008
The sequencing and annotation of insect genomes and comparative genomics are providing new insights into the molecular underpinnings of insect-specific processes. These have led to a variety of biotechnological applications to pest management, some with large economic potential. (EurekAlert!)
TGen and Washington University researchers discover new approach to treating endometrial cancer Sep 1, 2008
Sept. 1, 2008 Researchers at the Translational Genomics Research Institute (TGen) today announced a new approach to treating endometrial cancer patients that not only stops the growth of tumors, but kills the cancer cells ... "Our collaborative group's strong ties with the NCI's Gynecologic Oncology Group will allow us to rapidly take our findings from the lab to patients.'' Endometrial cancer, which invades the inner wall of the uterus, is the most common gynecological cancer in the United... (EurekAlert!)
Biotech firms plant roots in Tucson area to lure top talent Aug 30, 2008
The state of Arizona and city of Phoenix has invested tens of millions on a downtown biomedical hub anchored by the Translational Genomics Research Institute and a new medical school ... High Throughput Genomics. (AZCentral -- Business)
DNA databases blocked from the public Aug 29, 2008
Dr. Dave Craig, a researcher at the Translational Genomics Research Institute and lead author of the study, said the innovation "opens a Pandora's box of questions.". There are few places in the world where it's not only normal but also desirable to laugh uncontrollably and scream like a maniac. (Los Angeles Times)
Nature Genetics Aug 29, 2008
The Genomics of Common Diseases 2008. Nature Genetics in association with The Wellcome Trust is pleased to announce the second Genomics of Common Diseases meeting, to be held September 6 9, 2008 at The Broad Institute of MIT and Harvard in Cambridge, MA, USA. The meeting will feature emerging insights into the genetic architecture of complex disorders, and explore the shift toward understanding disease mechanisms and potential applications. (Nature News Service)
authors & referees @ NPG Aug 29, 2008
The range of topics covered includes genomics; functional genomics; evolutionary genetics; technology; multifactorial genetics; disease; chromosome biology; epigenetics; developmental biology; gene expression; and systems and network biology. Nature Reviews Molecular Cell Biology. (Nature News Service)
Application Notes Aug 29, 2008
Since proteins are subject to post-translational modifications, protein-protein interactions, and changes in expression patterns, proteomics applications are more comprehensive in scope than genomics. For these reasons, protein science may shed more light on cellular responses to environmental changes and stress conditions than DNA-based applications. (Nature News Service)
Nature Precedings Aug 29, 2008
Sequence and structure genomics have generated a wealth of data. Both the number and the diver. (Nature News Service)
British Journal of Cancer Aug 29, 2008
Genomics Institute of the Novartis Research Foundation. San Diego, CA. (Nature News Service)
TGen find promises big leap in forensics Aug 29, 2008
A research team from the Phoenix-based Translational Genomics Research Institute and the UCLA say that "genotyping microarrays," high-powered chips typically employed in a lab to hunt for a person's disease triggers, can be used to identify individuals based on DNA scooped from crime scenes, crowded rooms or other places ... "This has the potential to change a lot, but there needs to be more research into this," said Dr. David Craig, associate director of TGen's neurogenomics division. (AZCentral -- Business)
Brain-Derived Neurotrophic Factor and Obesity in WAGR Syndrome Aug 28, 2008
From the Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics (J.C.H., R.L.L., C.M.M., K.S.J.-G., D.C.A.-W., E.L.S., J.A.Y.), and the Laboratory of Clinical Genomics (O.M.R.), Eunice Kennedy Shriver National Institute of Child Health and Human Development; and the Genome Technology Branch (M.J.) and the Medical Genetics Branch (F.L.L.), National Human Genome Research Institute, National Institutes of Health all in Bethesda, MD; and the Molecular Neurobiology Branch,... (New England Journal of Medicine)
Despite rocky start, UofA medical school presses on Aug 27, 2008
Phoenix and the state have invested millions to develop and expand the medical school and to launch bioscience research facilities such as the Translational Genomics Research Institute to attract top-tier scientists. At the downtown campus, medical students rub elbows with top-notch genetic researchers who are developing advanced medical treatments. (AZCentral)
Unfinished Race Aug 27, 2008
In a feature , a team of scientists led by Craig Venter, the human genomics pioneer, affirms this pattern and discusses of medically important genetic differences among ethnic populations ... "Race/ethnicity should be considered only a makeshift solution for personalized genomics because it is too approximate," they write ... "Companies such as Navigenics, 23andMe, and deCODE will genotype 600,000 to 1,000,000 markers in an effort to offer personalized genomics; several hundred dollars covers... (Slate)
