Methylgene and Pharmion Start Phase II Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma Jan 9, 2008
In addition, the Epstein-Barr virus, HIV and familial history are known risk factors ... In addition, the Epstein-Barr virus, HIV, Hepatitis-C and familial history are known risk factors. (CCNMatthews Press Releases)
New drugs and hopes for an MS vaccine Dec 23, 2007
Now, research is bolstering suspicion that Epstein-Barr virus is the culprit. Epstein-Barr is a microbe that infects about 95 percent of American adults. (Albany Democrat-Herald, OR)
Advancing on MS: New drugs and hopes for a vaccine Dec 22, 2007
Now, research is bolstering suspicion that Epstein-Barr virus is the culprit. Epstein-Barr is a ubiquitous microbe that infects about 95 percent of American adults. (Herald Online, SC -- Health)
Infectious Diseases after Solid-Organ Transplantation Dec 20, 2007
Epstein Barr Virus and Post-Transplantation Lymphoproliferative Disorder. -->Polyomaviruses BK and JC. (New England Journal of Medicine)
Virus Discovered Using Same Tools As Host Cell Dec 20, 2007
Other herpes viruses, such as Epstein-Barr virus, contain microRNAs that are not similar in structure or function to miR-155. However, Epstein-Barr virus appears to promote cancer via a different route: by activating the expression of naturally occurring miR-155 in infected B-cells, the researchers note. (Science Daily)
Vaccine Shows Promise In Preventing Mono Dec 12, 2007
11, 2007) A new study suggests that a vaccine targeting Epstein-Barr virus (EBV) may prevent infectious mononucleosis, commonly known as "mono" or "glandular fever." ... Epstein-Barr virus (EBV) is one of the most common viruses in humans ... 28, 2005) Childhood infection with Epstein-Barr virus (EBV) is often asymptomatic, while in adolescents and adults it causes infectious mononucleosis (IM). (Science Daily)
* STDs may spread cancer Nov 20, 2007
"We worry about 'Should I eat those french fries or that apple?' but we don't manage our infections. I don't say, 'I think I'll have a little less Epstein-Barr virus today,'" said Julie Parsonnet, a researcher at Stanford Comprehensive Cancer Center in California who focuses on infectious diseases. "We are probably focusing on the wrong thing.". (Taipei Times, Taiwan -- World)
America May Over-vaccinate, According To New Research Nov 9, 2007
Once gathered, the data was then analyzed to determine the level of immunity in each individual for measles, mumps, rubella, chickenpox (Varicella-zoster virus), mononucleosis (Epstein-Barr virus), tetanus and diphtheria over an extended period of time. Upon further examination, researchers found that antibody responses caused by viruses such as measles mumps, and rubella remained at protective levels for several decades and in most cases, for life. (Science Daily)
ISU football: Moses avoids sea of self-pity Nov 9, 2007
Ironically, Blythe's bout with Epstein-Barr virus and an injury to Jon Davis gave Moses a chance at expanded playing time late in his junior year. He made a loud and clear statement by catching 24 passes, all in the Cyclones' final half-dozen games, and returning 15 kickoffs for 325 yards. (Waterloo-Cedar Falls Courier)
Some vaccines trigger immunity that lingers on Nov 9, 2007
This immunity lasted 19 years for diphtheria, 50 years for chickenpox, and stretched beyond lifetime limits for rubella or German measles, mumps, measles and the Epstein-Barr virus. "Measles, mumps and rubella were always described as childhood diseases and now we have one of the reasons why. Our immune system can remember them for a lifetime," said Slifka. (MSNBC -- Health)
Targeting tumors: A new approach proven? Nov 9, 2007
These include cervical cancer (caused by human papilloma virus), some liver cancers (caused by hepatitis B and C), and some lymphomas (caused by the Epstein-Barr virus). Over all, as many as 20 percent of cancers may be caused by viruses. (Why Files)
Humoral Immunity to Viral and Vaccine Antigens Nov 8, 2007
Methods We performed a longitudinal analysis of antibody titers specific for viral antigens (vaccinia, measles, mumps, rubella, varicella zoster virus, and Epstein Barr virus) and nonreplicating antigens (tetanus and diphtheria) in 45 subjects for a period of up to 26 years. In addition, we measured antigen-specific memory B cells by means of limiting-dilution analysis, and we compared memory B-cell frequencies to their corresponding serum antibody levels. (New England Journal of Medicine)
How One Virus Uses Mimicry To Replicate Successfully: Related Mechanisms May Trigger Some Cancers Nov 5, 2007
6, 2005) Researchers at the University of Pennsylvania School of Medicine have identified a link between a critical cancer pathway and an Epstein-Barr Virus (EBV) protein known to be expressed in a number of. . (Science Daily)
Cancer Treated As An Infectious Disease -- With Promising Results Nov 3, 2007
Prime examples are liver cancer (caused by hepatitis B and C viruses), cervical cancer (caused by human papillomaviruses) and certain lymphomas (caused by the Epstein-Barr virus) ... 1, 2001) Scientists in the University of Michigan Medical School have found a molecular link between aggressive breast and lymphatic cancers and the Epstein-Barr virus, which causes infectious. (Science Daily)
Kill the Virus, Stop the Cancer Nov 3, 2007
Scientists at the Albert Einstein College of Medicine of Yeshiva University in New York City say the finding could pave the way for conquering human cancers that are linked to preexisting viral infections, among them liver cancer (caused by the hepatitis B and C viruses), cervical cancer (from human papillomavirus) and lymphomas caused by the Epstein Barr virus. ADVERTISEMENT (article continues below) They key, they say, is to find and destroy the viruses before they turn cancerous. (Scientific American)
Cyclones improving, but K-State awaits Nov 3, 2007
The Cyclones were hurt by a muffed punt, an interception return for a touchdown and the absence of wide receiver Todd Blythe, who was out with Epstein-Barr virus. - Key matchup: Todd Blythe vs. Jordy Nelson. (Waterloo-Cedar Falls Courier)
Loss of Viral Control Tied to Lymphoma Risk Nov 2, 2007
NEW YORK (Reuters Health) - Patients who have abnormal reactive blood patterns when exposed to Epstein-Barr virus appear to have an increased risk of lymphoma, according to European researchers. In the International Journal of Cancer, Dr. Silvia de Sanjose of the Catalan Institute of Oncology, Barcelona and colleagues note that although Epstein-Barr virus is often thought to be benign, infection with this virus may lead to processes that can disturb the regulation of the immune system and... (MEDLINEplus)
Helena twins share a bond greater than volleyball Nov 2, 2007
Mikal, who has been afflicted with Epstein Barr Virus, has had to continually battle just to keep playing volleyball. "It's sort of like chronic mono," she said, describing how she's constantly fatigued. (Helena Independent Record, MT)
Cancer-Killing Virus Shows Promise as Metastatic Cancer Treatment Nov 2, 2007
1, 2001) Scientists in the University of Michigan Medical School have found a molecular link between aggressive breast and lymphatic cancers and the Epstein-Barr virus, which causes infectious. (Nov. (Science Daily)
Antiphospholipid Syndrome Oct 21, 2007
No significant association has been made with the Epstein-Barr virus (EBV). Resources. (Suite101.com)
An AIDS-related virus reveals more ways to cause cancer, Penn researchers find Oct 9, 2007
Other herpes viruses, such as the one that causes cold sores and Epstein-Barr virus, which causes mononucleosis, are able to hide out in cells as well. Whether these latent herpes viruses use some of the same strategies that we have found for LANA in KSHV has not been determined, says Robertson. (EurekAlert!)
Depression, Aging, And Proteins Made By A Virus May All Play Role In Heart Disease Oct 5, 2007
Glaser, head of Ohio State's Institute for Behavioral Medicine Research, has focused for years on Epstein-Barr virus (EBV), one of eight different herpesviruses that can remain dormant in the body for a lifetime ... The researchers also knew that as Epstein-Barr virus begins to multiply in cells in the body, it produces a protein called dUTpase that, in turn, can stimulate macrophages to make even more IL-6. (Science Daily)
Kissing disease spreads Oct 4, 2007
Even though mono cases are rising on campus, Smith said it is "not another plague," but only multiple cases of students who have been exposed to the Epstein Barr Virus. Smith also advised students not to avoid friends who do have mono, but use common sense while with them. (The University Echo, TN)
Virus jab may help combat cancer Oct 3, 2007
Initial tests show the vaccine - for the Epstein Barr virus (EBV) - has produced promising effects. Researchers recorded a heightened immune response to cancer cells infected with EBV.. (BBC News -- Health)
Virus, proteins effect heart disease Oct 3, 2007
He revealed that for years, he had studied Epstein-Barr virus (EBV), one of eight different herpes viruses that can remain dormant in the body for a lifetime ... They also had evidence that as Epstein-Barr virus begins to multiply in cells in the body, it produces a protein called dUTpase that can further stimulate macrophages to make even more IL-6 ... When the researchers exposed endothelial cells and the immune macrophages to Epstein-Barr virus and the dUTpase protein, the production of IL-6... (India Times, India -- Health/Science)
MethylGene and Pharmion Announce Orphan Drug Designation Granted by the European Medicines Agency (EMEA) for MGCD0103 for the Treatment of Hodgkin's Lymphoma Sep 24, 2007
In addition, the Epstein-Barr virus, HIV and familial history are known risk factors. The disease is slightly more prevalent in men than women, and the median age of diagnosis is 38. (CCNMatthews Press Releases)
End of the line Sep 23, 2007
Paluka-White, 51, has been diagnosed with Epstein-Barr virus, more commonly known as chronic fatigue syndrome. The disorder is characterized by debilitating, ongoing physical and mental exhaustion. (The Examiner)
Doctor Nails Down Possible Cause of CFS Sep 17, 2007
Some researchers and physicians have laid responsibility at the doors of different viruses, such as the Epstein-Barr virus and pavovirus. However, there was no concrete proof these viruses caused the disease, as there was no proof of the virus being present in the body itself and even if present, of causing any significant damage to any organ. (The Money Times)
Stomach Virus a Culprit in Chronic Fatigue Syndrome Sep 15, 2007
Several different viruses, including Epstein-Barr virus, cytomegalovirus and parvovirus have been implicated, along with enteroviruses. There are more than 70 different types of enteroviruses that can affect the central nervous system, heart and muscles, all of which is consistent with the symptoms of CFS.. (MEDLINEplus)
Virus Link To Chronic Fatigue Syndrome? Sep 14, 2007
Jones was among the first to suggest that chronic infection with the virus that causes mononucleosis, the Epstein-Barr virus, might explain the disease. But the failure to find persistent evidence of Epstein-Barr or any other virus in the blood of CFS patients led most researchers, including Jones, to look elsewhere for causes. (CBS News)
ME (myalgic Encephalitis) Stomach Virus Link Sep 14, 2007
Journal of Clinical Pathology (BMJ). ME is also known as Chronic Fatigue Syndrome. (Medical News Today)
Stomach virus 'could trigger ME' Sep 14, 2007
Viral infections, such as Epstein Barr virus (glandular fever), cytomegalovirus, and parvovirus, are also known to produce many of the symptoms associated ME.. Enteroviruses, which infect the bowel, cause severe but short lasting respiratory and gut infections. (BBC News -- Health)
Lethal Rabies Infection Halted In Brain Sep 6, 2007
In opportunistic CNS infections such as Epstein-Barr Virus and measles, the immune system often causes damage getting rid of the virus. Understanding how to vent the damage and get rid of the virus is very important. (Science Daily)
Boost for transplant patients Aug 16, 2007
Experts believe it is caused by the Epstein-Barr virus (EBV), which is carried by more than 90% of the population and which is better known for causing glandular fever. In many people, the virus does not cause illness but it can lead to cancer in transplant patients, whose immune systems are suppressed due to anti-rejection drugs. (Channel 4 News)
Ailing Kiffin is back, must take it easy Oakland coach under orders not to yell Aug 16, 2007
Ailing Kiffin is back, must take it easy / Oakland coach under orders not to yell. I guess a lot of head coaches coach that way anyway, so I'm going to get to see what it's like. (San Francisco Chronicle -- Sports)
Kiffin Goes Mano-a-Mono Aug 16, 2007
com, is caused by the Epstein-Barr virus. Symptoms may include fatigue, weakness, sore throat, fever, swollen lymph nodes, swollen tonsils, headache and skin rash. (San Francisco Chronicle -- Sports)
ZEN and the art of lawyering Jul 31, 2007
" After doing legal aid work in Alaska and Alameda County, she represented the United Farm Workers, then co-founded a labor law firm in Berkeley. But six-day workweeks and a divorce took their toll. In the 1980s, she contracted the Epstein-Barr virus. "I had to slow way down," she said. "I had to take a look at my life. " A visit to Green Gulch Farm Zen Center in Muir Beach allowed her to do just that. "I fell in love with it," she said. "It spoke to me in some visceral way. (San Francisco Chronicle)
viral hepatitis Jul 23, 2007
In 1956 Dr Saul Krugman, a New York paediatrician, was asked to resolve a problem at the Willowbrook State School, Staten Island, an overcrowded home to 4,000 mentally disabled children, among whom hepatitis and other infectious diseases were rife. Krugman s experiments involved both feeding and injecting infected blood into these children, and by the mid 1960s he had discovered two kinds of hepatitis, which would be later designated hepatitis A and hepatitis B. However, the ethics of Krugman s... (Suite101.com)
Rates of Lymphoma Increase Over 30 Years Jul 20, 2007
"These have included occupational exposures, viruses (Epstein-Barr virus, human T-lymphotropic virus 1 and human herpesvirus 6) and bacteria (staphylococcal superantigens).". "While the increased incidence of cutaneous T-cell lymphoma remains unexplained, it demonstrates the increasing importance of the role of the dermatologist to remain at the forefront of diagnosis and treatment" of the disease, Dr. Lessin continues. (Kansas City infoZine)
No longer viewed as 'yuppie flu' Jul 20, 2007
Montoya said some cases of the syndrome were caused when an acute infection set off a recurrence of latent infections of Epstein Barr virus and HHV-6, two pathogens that most people are exposed to in childhood. Flowers, the former figure skater, had high levels of antibodies to both viruses and was one of Montoya's initial CFS patients. (The Daily Reflector)
Epstein-Barr virus Jul 16, 2007
the first Virus to be Associated with a human cancer. Anthony Epstein and Yvonne Barr discovered their eponymous virus in the 1960s when examining tumour material sent from lymphoma patients by Denis Burkitt. (Suite101.com)
Cancer Risk In HIV, Transplant Patients Jul 11, 2007
HIV/AIDS patients are 11 times more likely to develop Hodgkin s lymphoma a cancer associated with Epstein Barr Virus - while there is almost four times the risk for those who have a transplant. There are a number of cancers associated with human papilloma virus, from cervical cancer to cancers of the mouth, penis and anus. (Science Daily)
Chronic Fatigue: Clues In The Blood Jul 9, 2007
Since 1999, the team has been tracking the long-term health of individuals infected with Ross River virus (RRV), Q fever infection and Epstein-Barr virus, which causes glandular fever. These [35] genes might point to the nature of the disease process that underlies CFS, which is currently unknown, said Professor Lloyd, who is based in the School of Medical Sciences at UNSW. None of them are ones that I would have predicted, except for those relating to neurotransmitters, he concedes. (Science Daily)
Infection-Related Cancers Elevated Among the Immunodeficient Jul 7, 2007
" Historically, only Kaposi's sarcoma, non-Hodgkin's lymphoma, and cervical cancer have represented AIDS-defining illnesses. Increased incidence of other cancers has been reported, but this was judged to be the result of lifestyle and other risk factors rather than immunodeficiency by investigators in the largest study to look at the issue, the AIDS-Cancer Match Registry Study published in the Journal of the American Medical Association in 2001. With publication of two large cohort studies... (MedPage Today)
Gene cluster linked to chronic fatigue Jul 5, 2007
The work was part of a larger project tracking the long-term health of people infected by three infections - the mosquito borne Ross River virus, Q fever bacterial infection and Epstein-Barr virus, which causes glandular fever - in the central NSW city of Dubbo. Prof Lloyd said the findings were the tentative beginnings of better understanding the disease. (Melbourne Herald Sun)
Sars patients can provide therapy Jun 21, 2007
The researchers exposed the cells to cocktail containing the Epstein-Barr virus and a short stretch of synthetic DNA that mimics some of the DNA found in bacteria and viruses. This not only triggered the cells to start dividing indefinitely, but also sped up the process, effectively creating a high-powered antibody factory. (Yahoo News -- SARS)
Risk Of Lymphoma In Rheumatoid Arthritis Decreased By Long-term Treatment With Steroids Jun 19, 2007
Steroid treatment outcome was not associated with the presence of the Epstein-Barr virus in the lymphomas. These results build on those of a previously published study that reported that orally prescribed and intra-articular (administered within the joint or joint cavity) steroids protect the individual from the development of malignant (actively cancerous) lymphomas in a dose responsive manner. (Science Daily)
Herpes Virus Hijacks DNA Repair Process Jun 16, 2007
They also showed that Epstein-Barr virus, a human herpes virus, has a similar protein ... Scientists then took a similar kinase from human Epstein-Barr virus and showed that introducing it into cells also activated the DNA damage response. (Science Daily)
After a bout with rare blood disease, TJ Harvey is happy playing golf again Jun 11, 2007
That carts got her playing 18 again, with this tournament meaning more than all the rest (The Morning Star)
Malaria And Epstein-Barr Virus Linked To Pediatric Cancer In Africa Jun 10, 2007
Malaria and Epstein-Barr virus (EBV) are known cofactors in its development, but to date, their relative contribution has not been well understood. In a new study published online in the open-access journal PLoS Pathogens, researchers at the Karolinska Institutet in Stockholm explain how certain Plasmodium falciparum antigens directly induce Epstein-Barr virus (EBV) reactivation, increasing the risk of Burkitt lymphoma ... Article: Chene A, Donati D, Guerreiro-Cacais AO, Levitsky V, Chen Q, et... (Science Daily)
Pharmion and MethylGene Report Preliminary Data for MGCD0103 at the 43rd American Society of Clinical Oncology (ASCO) Annual Meeting Jun 3, 2007
Currently, there is no known cause of the disease, but the Epstein-Barr virus, HIV and familial history are known risk factors. The disease is slightly more prevalent in men than women, and the median age is 38. (PR Newswire)
Left Out: Health-food chains continue to ignore Northeast Florida May 29, 2007
Epstein-Barr virus, the culprit behind the young Atlantan's chronic fatigue. "Some friends introduced me to eating organic and a vegetarian lifestyle," said Gottlieb, Native Sun's founder. (Jacksonville Business Journal, FL)
Herpes Infection May Be Symbiotic, Help Beat Back Some Bacteria May 22, 2007
Human herpes viruses include oral and genital herpes, the chickenpox virus, cytomegalovirus, Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus ... For the new research, Virgin's group worked with strains of mouse herpes virus closely related to human Epstein-Barr virus, Kaposi's sarcoma-associated herpes virus and cytomegalovirus. (Science Daily)
Hepatitis C carries another risk-cancer of the immune system May 10, 2007
Says study author Dr. Thomas Giordano, assistant professor of medicine at Baylor College of Medicine in Houston: "If I had hepatitis C, this would be one more piece of evidence that might make me consider treatment, though hepatitis C treatment can be difficult and is often unsuccessful. On the other hand, the risk of these cancers is so small; I wouldn't panic if wasn't getting treatment either. The overall risk is low. According to Giordano ,chronic stimulation of the immune system caused by... (Indian Catholic)
Treatment could 'train' cells to kill cancer May 10, 2007
Its link to the common Epstein-Barr virus (EBV), from the herpes family of viruses, is well established. Trained for battleEBV particles are located inside nasopharyngeal, and T-cells can be trained to recognize EBVs, induce an immune response and kill the cancer cells in the process, Chua said. (MSNBC -- Health)
Experts to train immune cells to kill nose cancer May 9, 2007
Its link to the common Epstein-Barr virus (EBV), from the herpes family of viruses, is well established. TRAINED FOR BATTLE. (The Star Online, Malaysia)
Hepatitis C may boost risk for non-Hodgkin's lymphoma May 9, 2007
Several infectious agents the Epstein-Barr virus, HIV and a bacteria called Helicobacter pylori are all associated with lymphoma. Engels says these organisms could cause cancer this way: Immune cells flock to the infection site, then make lots of copies of themselves to outnumber the viruses or bacteria that they want to kill. (USA Today)
Finnish Scientists Discover New Approach To Treat Virus-induced Lymphomas Mar 16, 2007
The cytotoxic effect of Nutlin-3a was specific for the KSHV-infected cells since Nutlin-3a did not induce apoptosis in lymphoblastoid cell lines transformed with another human tumor virus, the Epstein-Barr virus, despite of their wt p53 status. Moreover, the researchers show that Nutlin-3a has striking anti-tumor activity in vivo in a mouse xenograft model for the PEL. Nutlin-3a treatment resulted in a marked regression of all tumors in the treated animals in two weeks. (Science Daily)
As much as wrestlers relish the competition of the regular season, they know only three days really matter: the NCAA championship. Mar 11, 2007
" Darrell Vazquez, the Cal-Poly wrestler featured in this space earlier this season, won the 133-pound title at the Pac-10 meet to qualify automatically for the NCAA meet. Vazquez has battled symptoms of the Epstein-Barr virus for much of his college career. Hofstra, which had eight wrestlers qualify for NCAAs when it took home seven individual titles at the Colonial Athletic Association meet, will be sending only seven to the tournament. According to Intermatwrestle.com, 174-pounder Alton Lucas... (ESPN -- College Sports)
'Kissing disease' keeps infecting students Mar 6, 2007
He added that mono, caused by the Epstein-Barr virus, can be accurately diagnosed by a blood test. Though no cures are available for mono, people with severe sore throats may be given steroids to reduce the swelling. (Daily Collegian, PA)
Zoology 101: Sober Fratting Mar 5, 2007
" Or, if you prefer less romantic and more Jewish nomenclature, call it the Epstein-Barr virus. And I cannot kiss you, share wine cooler or play contact sports with you anymore for a doctor-recommended two to three weeks, ladies, until my spleen returns to its appropriate dimensions.I have become what many can rarely attest to have seen -- a sober, intentionally celibate freshman. With this in mind, an exploration of Dartmouth without the rose-colored glasses of inebriation and coital... (The Dartmouth Online, NH)
Viruses Used To Destroy Tumors Mar 2, 2007
Activating Epstein-Barr Virus Can Burst Tumors ... Researchers have found a way to activate Epstein-Barr viruses inside tumors as a way to identify patients whose infection can then be manipulated to destroy their tumors, according to a report in the journal Clinical Cancer Research ... A variety of cancers are more likely to occur in people who have been infected with the Epstein-Barr virus, but not everyone with these cancers has such infections. (Click2Houston, TX)
Researchers wake up viruses inside tumors to image and then destroy cancers Mar 1, 2007
PHILADELPHIA -- Researchers have found a way to activate Epstein-Barr viruses inside tumors as a way to identify patients whose infection can then be manipulated to destroy their tumors ... A variety of blood and solid cancers are more likely to occur in people who have been infected with the Epstein-Barr virus (EBV), but not everyone with these cancers has such infections ... "So we were hoping to find a way to turn latent Epstein-Barr virus on in these cancers, and use the thymidine kinase it... (EurekAlert!)
Fighting influenza & co. with 40,000 blood samples Feb 8, 2007
After the symptoms have disappeared, the pathogen, the Epstein-Barr virus, remains in the body for life and could permanently weaken the body's immune system with increasing age, a theory which is being investigated by RWTH Aachen. . (EurekAlert!)
Take Fatigue Seriously, Says Researcher Feb 3, 2007
Instead of dismissing grumblings about being tired or exhausted, people should take these complaints seriously before they lead to a worsened health state or even death, says a University of Alberta researcher investigating fatigue. Dr. Karin Olson, a U of A professor from the Faculty of Nursing, argues that there are differences between tiredness, fatigue and exhaustion and that recognizing those distinctions will help health-care workers create better treatment plans for their patients. (Science Daily)
