Virus weaves itself into the DNA transferred from parents to babies Sep 3, 2008
However, this research shows that a congenital HHV-6 infection differs greatly from a congenital CMV infection in that it is often integrated into the chromosomes of the baby rather than passed through the placenta. "This is the first time a herpes virus has been recognized to integrate into the human genome. To think that it's actually a part of us that's really fascinating," said Mary Caserta, M.D., associate professor of Pediatrics at the University of Rochester Medical Center and one of... (EurekAlert!)
CMV Infections Affect More Than Just Patients With Compromised Immune Systems Jul 28, 2008
ScienceDaily (July 27, 2008) An infection due to a virus called cytomegalovirus (CMV), which most commonly affects people with compromised immune systems, can also affect hospital intensive-care patients who have no immune-system problems, University of Washington researchers have found. CMV infection is also associated with longer hospital and intensive-care unit (ICU) stays independent of other causes, according to the study, published July 23 in JAMA, the Journal of the American Medical... (Science Daily)
CMV infections affect more than just patients with compromised immune systems, researchers find Jul 25, 2008
Public release date: 24-Jul-2008. Contact: Justin Reedy. (EurekAlert!)
Late Congenital Cytomegalovirus Has No Effect on Fetal Outcome Jun 25, 2008
Gindes and colleagues note that although newborns born with CMV infection can developing hearing loss and neurodevelopmental disorders, it is not known if fetuses infected at a later stage of pregnancy have fewer effects. To investigate, the researchers studied 28 women who developed CMV infection after 25 weeks of pregnancy ... "Although third trimester CMV infection carries a high transmission rate," the researchers conclude, "it has no deleterious effect on the fetal outcome.". (MEDLINEplus)
Viropharmas Camvia may change current treatment paradigm in stem cell transplant market Apr 3, 2008
Both prophylaxis and preemptive therapy are used to prevent the development of CMV infection after transplantation ... Dr Drew Winston, an investigator at UCLA Medical Center, said Camvia can reduce the incidence of CMV infection and, unlike the current drug ganciclovir, it does not cause myelosuppression ... Patients may face the problem of late CMV infection after discontinuing prophylaxis treatment. (FT.com -- Markets)
Doctors urged to combat birth-defect virus Jan 25, 2008
The CDC said a nationwide survey of 305 obstetricians and gynecologists showed only 44 percent counseled patients about how to avoid CMV infection ... The CDC said 5,000 to 8,000 babies are born annually in the United States with disabilities associated with CMV infection. (MSNBC -- Health)
Small RNAs and Large DNA Viruses Dec 20, 2007
Please for full text and personal services. Volume 357:2630-2632. (New England Journal of Medicine)
ViroPharma nets U.S., European orphan status for CMV drug Dec 3, 2007
According to ViroPharma, U.S. human CMV infection rates average between 50 percent and 85 percent of adults by 40 years of age, but in healthy adults the infection causes little to no apparent illness. In immunocompromised individuals -- including cancer patients, HIV patients and transplant patients -- CMV can lead to serious disease or death. (Philadelphia Business Journal, PA)
A Man with Inflammatory Bowel Disease, Fever, and Bloody Diarrhea Nov 15, 2007
NEJM -- Case 35-2007 -- A 30-Year-Old Man with Inflammatory Bowel Disease and Recent Onset of Fever and Bloody Diarrhea. Please for full text and personal services. (New England Journal of Medicine)
HIV-positive Patients have a Low Prevalence Of H Pylori In Gut Oct 19, 2007
Various opportunistic infections of Upper gastrointestinal tract is likely to occur in HIV-positive patients with a CD4 lymphocyte counts less than 200/muL, such as CMV infection, Candida esophagitis. Another interesting conclusion is that 84 % of HIV-positive patients co-infected with HCV and/or HBV infection. (Science Daily)
Top-Line Efficacy Data Presented from Phase 2 Trial of Alemtuzumab in Multiple Sclerosis Oct 15, 2007
The most commonly reported adverse reactions in patients with B-CLL were infusion reactions (fever, chills, hypotension, urticaria, nausea, rash, tachycardia, dyspnea), cytopenias (neutropenia, lymphopenia, thrombocytopenia, anemia), and infections (CMV viremia, CMV infection, other infections). In clinical trials, the frequency of infusion reactions was highest in the first week of treatment. (PR Newswire)
New vaccine prevents CMV infection and disease in mice Jun 23, 2007
Public release date: 22-Jun-2007. Researchers at the University of California, San Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences have patented a strategy for developing a human vaccine to prevent against Human Cytomegalovirus (hCMV) infection and disease. (EurekAlert!)
Fighting CMV Infection Apr 23, 2007
April 23, 2007 - 10:40 AM Sub-Navigation. (Liz Bonis) -- Researchers are testing a new vaccine that could eventually help newborns from contracting a serious virus. (WOKR13 Rochester)
Vaccine may fight common fetal virus Feb 22, 2007
Vaccinated animals had fewer dead offspring and were less likely to transmit the CMV infection to their babies than unvaccinated guinea pigs, the researchers found ... It demonstrates for the first time in a relevant animal model of congenital CMV infection that a vaccine strategy thats being considered for human clinical trials is successful in ameliorating disease in newborns, Schleiss said in a telephone interview. (MSNBC -- Health)
Experimental vaccine given during pregnancy reduces stillbirths from common virus Feb 22, 2007
Information about CMV infections acquired before birth is available from NIHs National Library of Medicine at. More information about CMV is available from NIHs National Institute of Allergy and Infectious Diseases at. (EurekAlert!)
Coping with HIV| Jan 11, 2007
CMV infection is often heralded by prolonged fever, malaise, lack of appetite, fatigue, night sweats and muscle and joint pains. During these episodes any investigations of liver functions and blood indices will be abnormal. (iAfrica.com)
ViroPharma Announces Presentation of Additional Maribavir Data at American Society of Hematology Meeting Dec 12, 2006
"This marks an exciting advancement for preventing this serious infection." "This is the first presentation of a more extensive Phase 2 data set at a scientific meeting. These data clearly demonstrate, among other outcomes, that prophylaxis with maribavir significantly reduces the incidence of CMV infection in this population," remarked Stephen Villano, M.D., ViroPharma's vice president of clinical research and development ... All subjects were monitored frequently for CMV infection by CMV pp65... (PR Newswire)
Innovative Method For Creating A Human Cytomegalovirus Vaccine Outlined Aug 4, 2006
CMV infection is widespread in the U.S., according to the Centers for Disease Control and Prevention. Between 50 and 80 percent of adults are infected with CMV by the time they reach 40 years of age, but the virus generally poses little threat to them. (Science Daily)
Budd–Chiari Syndrome and Factor V Leiden in a Neonate Aug 3, 2006
The baby was transferred to our hospital; CMV infection was. . (New England Journal of Medicine)
Cytomegalovirus Infection Tied to Miscarriage Risk Jun 8, 2006
Miscarriage rates in healthy women with vaginal shedding of CMV -- indicating they have the infection -- are significantly higher than those in comparable women without CMV infection, report Dr. Hiroyuki Tsutsumi and colleagues at Sapporo Medical University School of Medicine ... One possible underlying reason, suggest the investigators, is that CMV infection may cause excessive immune reactions between the mother and the fetus. (MEDLINEplus)
ViroPharma Announces Positive Phase 2 Results Demonstrating That Maribavir Significantly Reduces CMV Reactivation Mar 30, 2006
"These results could potentially change the current treatment paradigm in which transplant physicians usually wait until CMV can be detected in the blood, indicating that the virus is multiplying, before initiating treatment. If untreated, there is a high risk that the virus will continue to replicate and lead to potentially lethal CMV disease. The reason physicians are reluctant to use currently available therapies as prophylaxis, particularly in stem cell transplant, is the toxicities... (PR Newswire)
