Immune Cells From Patients With Rheumatoid Arthritis Have Prematurely Aged Chromosomes Mar 6, 2009
23, 2003) Scientists at Dana-Farber Cancer Institute and their colleagues have found that much of the widespread damage that the rare genetic disease ataxia telangiectasia, or AT, wreaks on the body results. (Oct. (Science Daily)
Scientists identify gene involved in pancreatic cancer Mar 3, 2009
Expression of the gene, Ataxia Telangiectasia Group D Complementing gene (ATDC), is on average 20 times higher in pancreatic cancer cells than in cells from a normal pancreas. What's more, the gene appears to make pancreatic cancer cells resistant to current therapies. (Xinhuanet, China)
Case Report Of A Brain And Spinal Tumor Following Human Fetal Stem Cell Therapy Mar 1, 2009
Ninette Amariglio and Gideon Rechavi from the Sheba Medical Center, Tel Aviv, Israel, and colleagues report the case of a boy with a rare genetic disease, Ataxia Telangiectasia, who underwent human fetal stem cell therapy at an unrelated clinic in Moscow and who, four years after the therapy began, was shown to have abnormal growths in his brain and spinal cord ... For example, the tumor contained both XX (female) and XY (male) cells and had two normal copies of the ATM gene (the gene causing... (Science Daily)
Stem cell transplant reverses early-stage multiple sclerosis Feb 12, 2009
They experienced improvements in areas in which they had been affected by multiple sclerosis including walking, ataxia, limb strength, vision and incontinence. The study will be published in the March issue of the Lancet Neurology. (The Virtual Medical Centre)
Cyclists Bring Attention to Disabling Disease -- Friedreich's Ataxia Mar 28, 2008
Among the cyclists, a young man named Kyle Bryant, who isn't letting Friedreich's ataxia slow him down ... Although Bryant's legs have limited movement, a specially designed bike allows him to go great distances -- with the purpose of getting the word out about ataxia ... Bryant was diagnosed with Friedreich's ataxia about 10 years ago. (KLAS-TV.com, NV)
SAN MARCOS: Cal State San Marcos hosting expo for disabled Mar 25, 2008
Those who attend will have a chance to hear from Jason Hinkle, a 31-year-old documentary filmmaker diagnosed with ataxia in the early 1990s. The disorder makes it difficult to coordinate voluntary muscle movements, leading to slurred speech, difficulty walking and other physical problems. (North County Times)
Woman overcomes years of bullying Mar 22, 2008
When Izzy was just a year old, she was diagnosed with the canine equivalent of the Friedrichs Ataxia that afflicts Ford ... When she was 13, doctors diagnosed her with Friedrichs Ataxia, a genetic, progressive condition that affects the central nervous system and erodes muscular control and speech. (MSNBC -- Health)
Autism and vaccines: What's the link? Mar 22, 2008
Symptoms of exposure to this class of compounds includes aphthous stomatitis, catarrhal gingivitis, nausea, liquid stools, pain, liver dis- order, injury to the cardiovascular system and hematopoietic system, deafness and ataxia. Exposure may be fatal. (Atlanta Journal-Constitution -- Opinion)
Nucleotide Repeat Disorders Mar 20, 2008
Huntington s disease, Friedrich s Ataxia, the Spinocerebellar Ataxias, Fragile X syndrome, and Myotonic Dystrophy all arise from mutations in different genes but what do they have in common ... For this particular case, both Friedrich s Ataxia and Myotonic Dystrophy Type 1 are examples of expansion disorders where the duplication occurs in a region that does not encode the actual protein. (Suite101.com)
Continue reading Feb 27, 2008
He had Friedreich's Ataxia, a rare, degenerative neuromuscular disease that affects only one in 50,000 people ... Friedreich's Ataxia is a genetic disease that causes progressive damage to the nervous system resulting in symptoms ranging from a loss of balance and coordination and speech problems to heart disease ... Luke, their middle child, is healthy, but when their 10-year-old daughter Kennan was 4, Tracey recalls clearly the day she saw her exhibiting the telltale signs of Friedreich's... (Kingsburg Recorder, CA)
“Bud’’ Stenseth, a beloved family man and mail carrier Feb 17, 2008
Darrell Bud Stenseth lost a short, but courageous battle with lung cancer after years of battling Ataxia, a nerve disease that severely limited his mobility and confined him to a walker. (For a complete news story see the Friday, February 15, 2008 Journal) 2/15/08. (Devils Lake Daily Journal, ND)
Americans Head Overseas for Stem Cell Treatment Feb 15, 2008
Flynn has Ataxia, a genetic disease that causes progressive deterioration of motor skills, vision and speech. Once hands-on and active in his prime, Flynn now struggles to navigate his own home. (ABC News)
Santhera says ready availability of idebenone complicating clinical trial process Feb 14, 2008
Recruitment in ongoing European Phase III clinical trials of idebenone in Friedreichs ataxia (FA) patients is proving difficult, the drugs sponsor Santhera told Pharmawire, because of the ready availability of the drug across the continent. US trial investigators have also said that widespread non-prescription use of antioxidants in the FA community was a complicating factor in clinical trials. (FT.com -- Markets)
Take me back to the ballgame Feb 14, 2008
Brush suffered from locomotor ataxia, a progressive disease of the nervous system, and hoped to improve his health by partaking of the curative waters. After just a few days in Marlin, Brush said he was "...deriving a world of benefit from the Marlin water ... I will become a walking advertisement for Marlin." Likewise, sportswriter Sam Crane, who was ill upon arriving in Marlin, said he was "100% better after my first two baths in the mineral water."3U, 13. (Marlin Democrat, TX)
Twins awards dinner symbolizes change Jan 26, 2008
In the first two years of the event, all the proceeds went to the Bob Allison Ataxia Research Center in memory of the former Twins player who passed away from the disease. This year, the benefit expanded to include muscular dystrophy, Parkinson's disease and ALS among its causes. (MLB.com -- Minnesota Twins)
Ten on faculty receive new appointments Jan 25, 2008
Gomez is widely recognized for his clinical expertise in the diagnosis and treatment of spinocerebellar ataxias and his research on the molecular and genetic causes of these disorders. At the University of Minnesota, he established the Ataxia Clinic, a nationally recognized specialty clinic for patients with these rare degenerative diseases ... He also is a founding member of the Cooperative Ataxia Group, a national consortium of ataxia specialists. (Univeristy of Chicago Chronicle, IL)
More Sick Americans Head to China For Treatments Jan 7, 2008
Diseases treated there range from stroke and spinal cord injuries to cerebral palsy and ataxia, a rare neurological condition that can cause slurred speech. The hospital says its stem cell injections are combined with daily, three-hour doses of intravenous drugs designed to stimulate production of the patient's own stem cells. (Fox News)
Ailing Americans seek unproven Chinese treatments Jan 6, 2008
Diseases treated there range from stroke and spinal cord injuries to cerebral palsy and ataxia, a rare neurological condition that can cause slurred speech ... Tiantan Puhua, a joint venture between Asia's largest neurological hospital and American Pacific Medical Group, uses stem-cell injections to treat diseases ranging from stroke and spinal cord injuries to cerebral palsy and ataxia. (USA Today -- News)
Anti-malarial Drug Prevents Cancer In Mice, Study Shows Dec 30, 2007
29, 2007) New data generated by a team of researchers from St Jude Children's Research Hospital, Memphis, and Scripps Research Institute, Jupiter, have indicated that the antimalarial drug chloroquine effectively prevents cancer in mouse models of two distinct human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia ... In the study, chloroquine was shown to inhibit the development of Myc-induced lymphomas (a mouse model of Burkitt lymphoma) and to inhibit the development of lymphomas... (Science Daily)
Malaria Drug Promising Against Cancer Dec 27, 2007
Scientists at The Scripps Institute and St. Jude's Children's Research Hospital found that chloroquine, which has been in use since 1946, blocked Burkitt lymphoma, a cancer of the lymphatic system, and ataxia telangiectasia (A-T), a rare immunodeficiency disease that predisposes people to cancer, especially leukemia and lymphoma. The study was published online Dec. 20 by the Journal of Clinical Investigationand will appear in the January print edition. (U.S. News & World Report)
Betsy's Fight to End FA Dec 13, 2007
Fort Stockton residents have another opportunity to help fight Friedreich's Ataxia, the disease that has claimed the life of Betsy Neyland, and threatens the life of her sister, Emily ... Friedreich's ataxia is an inherited disease that causes progressive damage to the nervous system resulting in symptoms ranging from gait disturbance and speech problems to heart disease ... "Ataxia," which refers to coordination problems such as clumsy or awkward movements and unsteadiness, occurs in many... (Fort Stockton Pioneer, TX)
Skier pushes herself onto the trails once again Nov 26, 2007
"It was right before Mark got really sick,'' she said. Mark was Lizzie's husband. Her skiing would stop as his spinocerebellar atrophy ataxia, a debilitating disease, went from bad to worse to nightmarish. "It gave me a different perspective about life and death,'' Lizzie said ... "Mark ... had hereditary ataxia. While I could still coach, I'd tell new skiers that (when) on skis for the first time we all have ataxia. Ataxia means uncoordinated walking.'' It happens to all of us in some... (Anchorage Daily News)
UK Children Should Be Vaccinated Against Chickenpox Nov 9, 2007
Complications included - septic shock - pneumonia - encephalitis - ataxia (uncoordinated movement) - toxic shock syndrome - necrotizing fasciitis ('flesh eating' bacterial infection) ... After leaving hospital 40% of the children had ongoing problems as a result of the chickenpox, such as ataxia and skin scarring. (Medical News Today)
Chickenpox jab should be added to MMR, scientists say Nov 8, 2007
The study found 112 cases over 13 months where children suffered severe complications, which required hospital treatment for conditions such as pneumonia, blood poisoning, encephalitis, ataxia (loss of control of limbs), toxic shock and the flesh-eating bug necrotising fasciitis ... "The study, Severe Complications of Chickenpox in Hospitalised Children in the UK and Ireland, found that 40% of the children studied had ongoing problems, most commonly ataxia or skin scarring. Most of the children... (Guardian Unlimited -- UK)
E-911 board members should reconsider positions Oct 13, 2007
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Daily marathon Oct 4, 2007
Borland is attempting to run 63 consecutive marathons across the U.S. to raise awareness and funds for ataxia telangiectasia, a rare terminal and degenerative disease that restricts those afflicted to a wheelchair by age 10 ... 2 miles a day for 63 consecutive days while pushing a jogging stroller to raise awareness for Ataxia Telangiectasia, a rare, degenerative disease that strikes in early childhood. (The Examiner)
Malad family to run marathon Sep 27, 2007
Ben and Rebekkah Ward, 3, were diagnosed this year with Ataxia Telangiectasia, or A-T, which combines the worst symptoms of cerebral palsy, cystic fibrosis, muscular dystrophy, cancer and immune system deficiencies. About 500 people, mostly children, are afflicted by the disease nationwide, but Ben and Rebekkah are the only known fraternal twins suffering from A-T. Tim Borland, who is attempting to run 63 marathons in as many days, will push the twins in a stroller during the Colorado marathon. (Pocatello Idaho State Journal, ID)
Neyland family receives more than blessings from Scharlach Foundation Sep 27, 2007
The Neyland girls were afflicted at birth with a rare condition known as "Friedreich Ataxia." It is an abnormality of the motor and sensory nerve conduction system and involves the spinal cord mainly, with degeneration of the spinal cord tracts. There is no proven therapy for the condition. (Fort Stockton Pioneer, TX)
Annual MDA telethon coming up on Labor Day! Sep 1, 2007
I have two daughters, Betsy and Emily, that were diagnosed with Friedreich's Ataxia at ages 10 and 12. Friedreich's Ataxia (FA) is one of these diseases under the MDA umbrella ... Money can be directed directly for research for Fredreich's Ataxia by giving to MDA-SAM. SAM stands for Seek A Miracle. (Fort Stockton Pioneer, TX)
Helping kids cope with a debilitating condition Sep 1, 2007
Nearly three years ago, Liam was diagnosed with ataxia telangiectasia (A-T), a condition that combines the worst symptoms of muscular dystrophy, cerebral palsy, cystic fibrosis, cancer, and the immune deficiencies of AIDS. Most kids with A-T must use a wheelchair by age 10, and many do not survive past their teenage years ... Cowand said she will always remember the day when she first realized her second-born son may have A-T. Although Liam had been diagnosed with ataxia and had what she called... (AZCentral -- News)
A Fight To Be Heard Aug 29, 2007
As is common with spinocerebellar degeneration, Harmon was experiencing the onset of ataxia the progressive degeneration of muscle control and balance ... Harmon went on to choke three times during the next two years, each episode reinforcing what he'd long suspected but was reluctant to admit: The ataxia was creeping into his throat. (City Pages)
Stem-cell therapy: Cure or hoax in China? Aug 24, 2007
landscaper with ataxia, flew to Nanshan for four spine injections and two IV drips. Ataxia is a progressive disorder that prematurely kills the nerve cells responsible for balance and co-ordination, and is one of the long list of neural conditions that Beike will treat ... But he says that was probable considering the degenerative nature of ataxia. (Globe and Mail)
Protein 'Chatter' Linked To Cancer Activation Aug 20, 2007
The research, published August 13th in Nature Structural & Molecular Biology, sheds new light on the pathology of three related but non-curable cancer-predisposed human disorders: ataxia telangiectasia, ataxia telangiectasia-like disorder, and Nijmegen breakage syndrome ... Zhu adds that patients with ataxia telangiectasia, ataxia telangiectasia-like disorder, and Nijmegen breakage syndrome experience an accelerated rate of loss of DNA from chromosome ends ... According to the U.S. National... (Science Daily)
Nerve cell stretchiness uncovered Aug 18, 2007
The finding may help to explain why people with a condition called spinocerebellar ataxia progressively lose co-ordination and movement ... Recent studies have shown that people with a condition called spinocerebellar ataxia type 5, a neurodegenerative disease that develops between the ages of 10 and 68, have a mutation in one of the genes ... " There are thought to be more than 20 types of hereditary spinocerebellar ataxia, for which there is no treatment and commonly results in people needing... (BBC News)
European EMEA Acceptance of Marketing Authorization Application Filing for SNT-MC17 in Friedreich's Ataxia by Santhera Aug 16, 2007
LIESTAL, Switzerland and OSAKA, Japan, August 16 /PRNewswire-FirstCall/ -- Santhera Pharmaceuticals (SWX: SANN, "Santhera"), a Swiss specialty pharmaceutical company with a focus on neuromuscular diseases, and Takeda Pharmaceutical Company Limited (TSE:4502, "Takeda"), jointly announced today that the European Medicines Agency (EMEA) has accepted the filing of the Marketing Authorization Application (MAA) for Santhera's lead compound SNT-MC17 (INN: idebenone, originally developed by Takeda) for... (PR Newswire)
Recovery looks like a miracle Aug 3, 2007
"He couldn't walk right. He was wobbly," Murakoshi recalled, describing a condition -- an inability to control his limbs -- known as ataxia. Murakoshi sent Sal to Franklin Square Hospital in Rosedale, and to Sinai Hospital in Baltimore, where he had a magnetic-resonance imaging exam and a spinal tap, and where he was diagnosed with mycoplasma pneumonia, a bacterial infection that can cause inflammation in the brain. (North County News, MD)
Faith & family Jul 22, 2007
Andrew has Friedreich's ataxia ... He typed "Friedreich's ataxia" into Internet search engines and felt his heart sink as he read about how the disease affects the nervous system, causing progressive muscle weakness, loss of coordination, vision impairment, hearing loss and other problems ... If God knew they were right for each other, the Boyntons reasoned, why didn't he warn them that they both were carrying recessive genes that could produce children with Friedreich's ataxia. (Fresno Bee -- Local)
Webcast and Experts Consortium Highlight National Fragile X Awareness Day Activities Jul 20, 2007
The same genetic mutation that results in FXS is also known to cause balance, tremor and memory problems in adult male carriers (a condition known as fragile X-associated tremor ataxia syndrome, or "FXTAS") and reproductive problems in female carriers (the condition of premature ovarian failure, or "POF"). When all three Fragile X-related conditions are taken into account, more than one million Americans are either affected or at-risk to be affected. (PR Newswire)
Scientists Discover Role Of Enzyme In DNA Repair Jun 29, 2007
Scientists from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Cancer Institute (NCI), and Integrative Bioinformatics Inc. have made an important discovery about the role of an enzyme called ataxia telangiectasia mutated protein (ATM) in the body s ability to repair damaged DNA. NIAMS and NCI are part of the National Institutes of Health (NIH). When DNA within a cell is damaged, the cell s protective mechanism must do one of two things: repair the... (Science Daily)
Allogeneic Bone Marrow Transplantation in Mevalonic Aciduria Jun 28, 2007
Mevalonic aciduria is a rare, inborn error of isoprene biosynthesis characterized by severe, periodic attacks of fever and inflammation, developmental delay, ataxia, and dysmorphic features. This autosomal recessive disease is caused by a mutation in the mevalonate kinase gene that severely reduces mevalonate kinase activity. (New England Journal of Medicine)
Schools vow to revive ill child Jun 13, 2007
He also has autisticlike behavior, she said, as well as ataxia that makes him clumsy and mental retardation. He had his first seizure when he was 3 months old. (Fresno Bee -- Local)
Young boy selected as 'Pilot for a Day' at Davis-Monthan Jun 7, 2007
He suffers from mild cerebral palsy and ataxia. A news release from D-M indicates the program in which Matthew will participate was created to offer local children living with serious illnesses an enjoyable day devoted to the child and his or her interest in aviation. (FOX 11, AZ)
Syphilis screening, lithium fights neurodegeneration, monoclonal antibodies against avian flu ... May 29, 2007
As the researchers report in the international open-access medical journal PLoS Medicine, dietary lithium markedly improved the symptoms in a mouse model of spinocerebellar ataxia. Spinocerebellar ataxia type 1 (SCA1) is part of a group of inherited, incurable neurodegenerative disease called triplet repeat diseases ... Lithium alone is thus unlikely to be a miracle cure for spinocerebellar ataxia, but the research suggests that is might be of some help to patients who currently have no other... (EurekAlert!)
Insects' Nervous Systems May Provide Clues On Neurodegenerative Diseases May 28, 2007
Our mutant flies may provide a model system to study a class of human diseases whose symptoms include memory loss, ataxia, epilepsy and neurodegeneration. Both of these studies are being done in collaboration with scientists at Johns Hopkins University, the University of Iowa and New York University Medical School, and have been funded through support from the National Institutes of Health. (Science Daily)
Musical Savant John Frusciante Apr 29, 2007
In June he released The Will To Death, followed up by Ataxia Automatic Writing, and then an EP, The DC EP. The fall saw the release of Inside Of Emptiness and A Sphere In The Heart Of Silence, but unfortunately a printing error delayed the release of the sixth album (to make his six month mark) ... Ataxia: Automatic Writing: The second album in the series of six is not exactly a solo album ... What happened is that John became friends with Fugazi, and on this album he formed a band, Ataxia,... (VHI.com -- Virginmega.com Music News)
Moonlighting Enzyme Linked To Neurodegenerative Disease Apr 26, 2007
Friedreich's ataxia is one of those diseases few have heard of unless you know someone with the condition ... D., senior author of the study and a basic scientist at Mayo Clinic who specializes in Friedreich's ataxia ... Friedreich's ataxia is an inherited neurodegenerative disease of children and teens and is considered an orphan disease by the National Institutes of Health because of its rarity -- affecting one in 40,000. (Science Daily)
Autoimmune Hearing Loss Mar 31, 2007
About 50 percent of patients have vestibular symptoms, including disequilibrium, ataxia, and motion intolerance. Diagnosis. (Suite101.com)
FragileX Walk planned April 21 Mar 25, 2007
Fragile X-Associated Tremor Ataxia Syndrome (FXTAS), a condition which affects balance, tremor and memory in some older male gene carriers. Carriers of permutation (CGG) expansions of the fragile X gene are generally thought to be spared most of the problems associated with the full mutation; however, a newly identified neurological disorder, involving progressively severe tremor and difficulty with walking and balance, appears to specifically affect some older permutation carriers, generally... (Canton Daily Ledger, IL)
"Bong Hits 4 Jesus" banner brings duo to D.C. Mar 18, 2007
Think about this wrote on March 17, 2007 2:27 PM:"All of you people who keep saying that you don't support drug use are missing a very important fact here. What do you do when you get a headache? a cold? a broken bone? toothache? cancer? if you do not support drug use, then it has to be across the board. You don't think twice about taking a "drug" for simple things like a headache. Be thankful that there aren't a whole class of people who think using aspirin or ibuprofin is wrong and you are... (Rapid City Journal, SD)
Disabled woman and carer found murdered in flat Mar 17, 2007
She suffered from cerebellar ataxia, a muscle wasting disease that affects the nervous system and causes unsteadiness and a lack of coordination ... Of six siblings - three males and three females - she, Ms Hale and their brother Peter, all had cerebellar ataxia ... Mrs Smee added: "She was diagnosed with the ataxia in 1989 and she has been getting gradually worse. It made her much more vulnerable and meant she couldn't walk properly. We couldn't see each other all the time, but I was always at... (Guardian Unlimited -- UK)
Santhera Reports Successful 2006 Mar 2, 2007
The results reflect the significant progress that the Company has made across all areas of its business including: - Product development, where the Company is preparing to file the Marketing Authorization Approval (MAA) for its lead compound SNT-MC17 (INN: idebenone) for Friedreich's Ataxia (FRDA) in Europe ... Dr Klaus Schollmeier, Chief Executive Officer, commented: "2006 was a very busy and successful year for Santhera. All our development projects made significant progress, most notably our... (PR Newswire)
Happiness with Gluten Elimination Feb 20, 2007
It is also being linked with schizophrenia and ataxia, which is a balance related problem ... Gluten Ataxia and Immune System Related Balance Problems ... In one study with 12 people with idiopathic (no known reason) ataxia (loss of balance), gluten was found to be relevant in 8 cases. (Suite101.com)
Benefits of a Gluten-Free Diet Feb 20, 2007
Many people may benefit notably from a gluten-free diet, including those with Celiac disease, M.S., brain fog, seizures, arthritis, osteoporosis, autism, diabetes, ataxia ... - Ataxia (loss of balance) ... - Late-onset Friedreich ataxia. (Suite101.com)
New Spin on Chronic Dizziness Feb 20, 2007
"Because of the study's focus on chronic nonspecific dizziness, patients with migraine who presented to the Balance Center with ongoing episodes of vertigo or ataxia were excluded," the authors noted. "Nevertheless, approximately one third of patients in the migraine group had experienced vertigo or ataxia during headaches in the past. The others had only nonspecific dizziness.". (MedPage Today)
A 56-Year-Old Woman with Rapidly Progressive Vertigo and Ataxia Feb 8, 2007
A 56-year-old woman was admitted to the hospital because of rapidly progressive vertigo and ataxia ... Shortly thereafter, slurred speech, rapidly progressive ataxia, and difficulty with ambulation developed. (New England Journal of Medicine)
Stem-Cell Refugees Feb 5, 2007
In addition to spinal cord injuries, doctors treat multiple sclerosis, cerebral palsy, and ataxia, a genetic disease that leads to deterioration of muscle function ... She has ataxia and had to give up teaching when the illness caused her to slur her words ... With ataxia patients, for example, "it is well known that improvements can be achieved with aggressive physical therapy," she says. (BusinessWeek)
Medulloblastoma Feb 3, 2007
There are associations with amplification of the oncogene OTX2, deletion of the short arm of chromosome 17 and certain diseases e.g. Ataxia Telangectasia syndromes ... There may also be ataxia (gross uncoordinated movement) as well as difficulty with finer movements. (Suite101.com)
Mutant Gene Shatters Nerves: Was Abe Lincoln Affected? Feb 1, 2007
The discovery may provide a new explanation for spinocerebellar ataxia type 5 (SCA5) -- a disease previously tied to a human version of the gene and identified in 11 generations of U.S. President Abraham Lincoln's family, starting with his paternal grandparents ... Those researchers reported there was a one-in-four chance the 16th president had spinocerebellar ataxia type 5 ... (January 23, 2006) -- Researchers at the University of Minnesota Medical School have discovered the gene responsible... (Science Daily)
Europe retreats as financials weigh Feb 1, 2007
00 on hopes of early US regulatory approval for its lead product, a treatment for the neuromuscular disease Friedreichs Ataxia. gained 4. (FT.com -- Markets)
Did Honest Abe Have Nerves of Glass? Jan 31, 2007
About a year ago, researchers at the University of Minnesota announced the discovery of a gene for a rare neurodegenerative disorder called spinocerebellar ataxia type 5 (SCA5) which can strike between early childhood and old age, affecting speech, writing and/or movement in a family descended from Lincoln. Scientists say the president himself had a one-in-four chance of suffering from the disease, which affects about 0. (Scientific American)
Lincoln family disease tied to mutant gene Jan 30, 2007
When the gene was disabled in tiny nematode worms, their nerve cells literally broke, and the University of Utah study said that could explain the origin of spinocerebellar ataxia type 5. The disease has plagued generations of Lincoln's family, starting with his paternal grandparents. (Buffalo News -- National)
Did Lincoln suffer from shattered nerves? Jan 30, 2007
The mutation of one of the beta spectrin genes causes the degenerative nerve disorder spinocerebellar ataxia type 5, which researchers at the University of Minnesota found in 90 out of 299 of Lincoln's living descendants in a 2006 test. Those afflicted with ataxia lose coordination and sometimes end up confined to a wheelchair ... Until now, most scientists thought ataxia occurred because nerve cells didn't have beta spectrin linking them together with the same strength they do in a healthy... (MSNBC -- Technology)
Study Yields Clues to Lincoln-Linked Nerve Disease Jan 29, 2007
MONDAY, Jan. 29 (HealthDay News) -- Tiny worms are revealing important clues to ataxia, a rare, debilitating neurodegenerative disorder that may have affected President Abraham Lincoln. A new study suggests that the defective gene behind spinocerebellar ataxia type 5 (SCA5) causes nerve cells to snap under the strain of everyday movement and eventually die ... Find out more about SCA5 and other ataxias at the. (Health-Finder)
