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    A Man with Headache and Visual Changes after Liver Transplantation  Jun 12, 2008
    Anterior Ischemic Optic Neuropathy. -->Infections after Liver Transplantation. (New England Journal of Medicine)

    The cause of all hereditary sensory and autonomic neuropathy type II cases has been established  Jun 11, 2008
    Their recent results will hereafter help to explain all the cases of hereditary neuropathy type II.. Hereditary sensory and autonomic neuropathy type II (HSANII) is a severe and early onset disorder that starts early during childhood ... Unfortunately no therapy is currently available for individuals suffering from hereditary neuropathy type II. In 2004, Dr. Rouleau's team identified the DNA sequence of HSN2 as encoding a novel gene but their more recent investigations have now shown that this... (EurekAlert!)

    In remembrance of loved ones  Jun 10, 2008
    He told those gathered at the Copper Queen Hotel for the dedication service that he had spent five years in a wheelchair due to the neuropathy that took away the feeling in his legs. That can come from the virus as well as from the medications. (Sierra Vista Herald, AZ)

    Drug Keeps Type 2 Diabetes at Bay  Jun 10, 2008
    About 1 in 10 individuals with impaired glucose tolerance shows signs of diabetic retinopathy (damage to blood vessels in the retina that may affect vision), and 5 percent to 10 percent of prediabetic individuals are estimated to have peripheral neuropathy (blood vessel damage in extremities). A drug to treat impaired glucose tolerance and prevent further decline is therefore of great importance. (Newsmax)

    Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting  Jun 9, 2008
    Presentation Details Statistically Significant and Clinically Relevant Results for SB-509 in Development for Treatment of Diabetic Neuropathy SAN FRANCISCO, June 8 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: ) announced today the presentation of encouraging Phase 1b clinical data from its ZFP Therapeutic(TM) program at the 68th Scientific Sessions of the American Diabetes Association (ADA). As disclosed in an oral presentation entitled, "Evidence of Neuroregeneration Using... (PR Newswire)

    Older Diabetics' Risk of Cardiac Ischemia Lower Than Thought  Jun 9, 2008
    Since it is common for people with diabetes to have neuropathy, a type of nerve damage, it was though many of them wouldn't feel any warning pain or it wouldn't feel strong enough to the diabetic to send him or her to a doctor. Study participants, evaluated over five years, consisted of 1,123 adults with type 2 diabetes in the United States and Canada who had no previous cardiac symptoms, diagnosis of coronary artery disease, and normal electrocardiograms. (Health-Finder)

    Treating Autism with Vitamin B6  Jun 7, 2008
    A very small number of children taking large doses of B6 suffer peripheral neuropathy, which causes numbness or tingling of the feet and hands. However, side effects are rare, and taking magnesium with vitamin B6 lowers the risk of them occurring. (Suite101.com)

    Neuromyelitis Optica  Jun 5, 2008
    The past episodes of acute myelitis and progressive neuropathy suggested that the patient had either. multiple sclerosis. (Suite101.com)

    Agent orange ‘win’ reversed for ‘blue water’ sailors  Jun 3, 2008
    By 2001, Haas had developed type-2 diabetes, peripheral neuropathy and loss of eyesight which he claimed were caused by herbicide exposure off Vietnam. His regional VA office denied the claim, saying service connection couldn t be established because Haas had not gone ashore. (Petersburg Progress Index, VA)

    Paclitaxel Poliglumex (OPAXIO(TM))/Capecitabine Regimen Well Tolerated and Active in Metastatic Breast Cancer  Jun 3, 2008
    "Given the convenient dosing schedule, a 15 minute infusion every 3 weeks, as well as no requirement for premedications and minimal hair loss associated with OPAXIO compared to other taxanes, the goal of the study was to determine if OPAXIO combined with capecitabine, an oral chemotherapy agent, as first- line therapy in metastatic breast cancer would prove to be an active and relatively well tolerated regimen," said Jack W. Singer, M.D., Chief Medical Officer of CTI. "The severe toxicities... (PR Newswire)

    Borrowing time for a little girl  Jun 3, 2008
    That was the day their toddler Hannah was diagnosed with a rare genetic disorder called giant axonal neuropathy. The disease damages the nerve pathways that carry signals from the brain. (Albany Times Union)

    Poniard Announces Positive Preliminary Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in First-Line Treatment of Colorectal Cancer  Jun 2, 2008
    None of the Phase 1 patients treated with picoplatin exhibited severe neuropathy (Grade 3 or 4), as is commonly seen in metastatic CRC patients treated with oxaliplatin in combination with 5-fluorouracil and leucovorin as part of the FOLFOX regimen. Neurotoxicities were not related to cumulative exposure of picoplatin. (PR Newswire)

    Easing The Pain After Cancer Surgery  Jun 2, 2008
    Monday, June 02, 2008. Acupuncture eases pain in head and neck cancer surgery Posted: 02 June 2008 1510 hrs. (Channelnewsasia.com)

    VELCADE(R) (Bortezomib) for Injection Based Treatment Delivers Impressive Complete Response and Survival in Patients With Newly Diagnosed Multiple Myeloma  Jun 1, 2008
    The reasons for discontinuation included peripheral neuropathy (8%), asthenic conditions (3%) and thrombocytopenia and diarrhea (each 2%). In total, 2% of the patients died and the cause of death was considered by the investigator to be possibly related to study drug: including reports of cardiac arrest, congestive heart failure, respiratory failure, renal failure, pneumonia and sepsis. (PR Newswire)

    Multiple Clinical Trials of VELCADE(R) (Bortezomib) for Injection Based Therapies Demonstrate High Complete Remission Rates in Patients with Newly Diagnosed Multiple Myeloma  Jun 1, 2008
    Side effects included thrombocytopenia, neutropenia, hyperglycemia and peripheral neuropathy ... Side effects were manageable and included hematologic toxicity and peripheral neuropathy ... No grade 4 peripheral neuropathy was observed. (PR Newswire)

    Acupuncture reduces pain and dysfunction in head and neck cancer patients after neck dissection  Jun 1, 2008
    "It does not treat illness, but acupuncture can control a number of distressing symptoms, such as shortness of breath, anxiety and depression, chronic fatigue, pain, neuropathy, and osteoarthritis.". "Cancer patients should use acupuncturists who are certified by the national agency, NCCAOM [National Certification Commission for Acupuncture and Oriental Medicine], and who are trained, or at least experienced, in working with the special symptoms and problems caused by cancer and cancer... (EurekAlert!)

    Preventing Lyme Disease: 5 Ways to Avoid Getting...  May 29, 2008
    "If you do get bitten or notice that characteristic bulls-eye lesion on your body, you should see your doctor right away, said Rahimian. The reason is because there are medicines that prevent you from getting the long-term consequences of Lyme disease. If you have early-stage Lyme disease, oral antibiotics such as doxycycline, amoxicillin, or cefuroxime axetil are most often prescribed. According to the National Institutes of Health (NIH), studies have shown that most patients can be cured... (Fox News)

    New Eloxatin(R) (oxaliplatin injection) Prescribing Information in the U.S. Includes Six-Year Overall Survival Data  May 28, 2008
    Peripheral sensory neuropathy ("tingling or numbness" in the fingers or toes) occurred in 92 ... Partial or total recovery was observed within 18 months following treatment in most patients experiencing grade 3 peripheral sensory neuropathy. (PR Newswire)

    TechCoire to host LifeScienceFest in Davis  May 23, 2008
    of Temecula, which is developing a device to treat diabetic neuropathy. of Sunnyvale, which plans to develop diagnostics and therapies for pregnancy disorders. (Sacramento Business Journal, CA)

    Relays for Life in New Milford and Washington celebrate, inspire  May 23, 2008
    they removed it, and then I started chemo," Mr. Oberndorfer said. "I had neuropathy from the chemo, where you can't feel your hands or feet. " After that, he was cancer free for a few months, but his doctors found another lesion on his liver this winter. "So I had radiation after that," he said. "Right now I'm in a holding pattern. (New Milford Times, CT)

    Erectile Dysfunction a Strong Harbinger of Heart Trouble  May 21, 2008
    "Neuropathy would interfere with the neurogenic responses feeding into proper erection," Monrad said. "And obstruction of blood flow into the arteries reduces the pressure needed to achieve erection.". (MEDLINEplus)

    Under the Tower News: Health Fair set for May 28 05-18-2008  May 18, 2008
    Included will be blood pressure, blood sugar, blood cholesterol, neuropathy and bone density screenings. Plan to attend this event and take advantage of the services provided to us by local vendors. (Plainview Daily Herald, TX)

    Eribulin Mesylate Demonstrated Anti-Tumor Activity in Heavily Pretreated Patients with Advanced Breast Cancer  May 16, 2008
    Phase II Data Presented at ASCO Showed Acceptable Tolerability Profile, with Low Incidence of Grade 3 and 4 Neuropathy WOODCLIFF LAKE, N.J., May 15 /PRNewswire/ -- The investigational chemotherapeutic agent eribulin mesylate (E7389) demonstrated activity in a heavily pretreated population of women with locally advanced or metastatic breast cancer, according to results of a multi-center Phase II clinical trial. The study also suggests that eribulin mesylate has a manageable tolerability profile,... (PR Newswire)

    Gene Drugs For Untreatable Diseases  May 15, 2008
    Diabetic neuropathy affects 10 million people in the U.S. and is the cause of at least 70% of the 100,000 amputations performed each year. Current treatment options are painkillers and antidepressants; no drugs are approved to reverse the nerve damage that occurs when blood glucose levels remain too high for an extended period. (Forbes -- Technology)

    Pomegranate juice can ease joint pain  May 12, 2008
    Your Connection to the. Web Search powered by YAHOO. (Athens Banner-Herald)

    Under the Tower News: Farewell to Steve and Betty Hurt 05-11-2008  May 11, 2008
    We also will have blood pressure, blood sugar, blood cholesterol, neuropathy and bone density screenings. Please plan to attend this event and take advantage of the services provided to us by local vendors. (Plainview Daily Herald, TX)

    Giuseppe Attardi, 84, studied cells for clues to aging  May 8, 2008
    Attardi also looked at possible links between mitochondrial mutations and myopathy, or muscle diseases, and neuropathy, peripheral nerve damage. He also experimented with switching mitochondria from cell to cell. (Atlanta Journal-Constitution -- World)

    Trial will kill me, says 'war criminal'  May 3, 2008
    The octogenarian also has peripheral neuropathy which causes numbness in the hands and feet and can lead to diabetes. Mr Zentai today said he was too sick to be sent to Hungary for trial. (The Australian)

    Exenatide and Rare Adverse Events  May 2, 2008
    To the Editor: Seven years after receiving a kidney transplant, a 44-year old woman with a 31-year history of type 1 diabetes mellitus and long-term complications (retinopathy, neuropathy, and end-stage renal disease) underwent an allogeneic islet-after-kidney transplantation with the use of a modified Edmonton protocol. 1 Islet-graft dysfunction with preserved C-peptide levels was observed after approximately 1 year. (New England Journal of Medicine)

    Capecitabine and Oxaliplatin for Advanced Esophagogastric Cancer  May 2, 2008
    Moreover, peripheral neuropathy occurs more frequently with oxaliplatin. 2,3 We therefore see no better profile for capecitabine and oxaliplatin in patients with advanced esophagogastric cancer. (New England Journal of Medicine)

    New Details Presented In Outbreak In Pork Processing Plant Workers  Apr 19, 2008
    Researchers are classifying this condition as an immune polyradiculoneuropathy, (a disease of the peripheral nerves and spinal nerve roots) and it has been referred to as "progressive inflammatory neuropathy." Details about the initial epidemiology investigation were described in an article in the Morbidity and Mortality Weekly Report on February 8 ... "This appears to be a new syndrome of immune-mediated polyradiculoneuropathy, or more simply, a novel neurological disorder caused by an immune... (Science Daily)

    Stricken QPP workers now 18  Apr 18, 2008
    Lachance detailed his ongoing findings of the condition, classified as an immune polyradiculoneurophy or progressive inflammatory neuropathy, during a press conference Wednesday as part of the American Academy of Neurology s 60th Annual Meeting in Chicago. He and peripheral nerve disorder specialist Dr. P. James B. Dyck have thus far evaluated and diagnosed 18 individuals, all of whom have shown abnormalities across neurological and antibody tests, as well as varying levels of symptoms, such as... (Austin Daily Herald, MN)

    Health in brief  Apr 18, 2008
    North Shore Neuropathy Support Group: The north shore neuropathy support group meets monthly at Beverly Hospital, 85 Herrick St. The group meets in the Lecture Hall located on the first floor of the hospital, 10 a.m. to noon. For information, call the group leader at 978-479-4339 or e-mail wpaster@adelphia. (Georgetown Record, MA)

    Dr. Dimitri Goundis to assist in drug development for Anavex  Apr 17, 2008
    In addition, Dr. Goundis spent several years with lead responsibility for the company's entire development portfolio, including compounds in Phases I, II and III. Dr. Goundis' background also includes director-level positions with The Medicines Company, where he was responsible for leading and managing the CNS business unit, and Roche, where he managed projects across a variety of therapeutic areas including Rocaltrol(R) in osteoporosis, Aurorix(R) in anxiety disorders and Alcar(R) in diabetic... (PR Newswire)

    More workers sick from pig-brain mist  Apr 17, 2008
    In January, the Centers for Disease Control and Prevention gave the condition a name progressive inflammatory neuropathy, or PIN.. The 18 patients identified by the Mayo Clinic developed their symptoms from the end of November 2006 through the first week of this month. (MSNBC -- Health)

    U.S. Sued Over Dropping of Benefits for Disabled  Apr 17, 2008
    The suit's plaintiffs include Eshetu Meri, 51, of Fairfax, a blind man who escaped from Ethiopia, where he was targeted for advocating democracy; Tasim Mandija, 80, of Philadelphia, a native of Albania who suffers from prostate cancer and neuropathy; and Rouzbeh Aliaghaei, 17, an Iranian who suffers from a rare genetic disorder that resulted in autism, seizures, mental retardation and an enlarged head. He came to the United States in 1998 when his parents escaped political persecution. (Yahoo News -- Disabilities and the Disabled)

    Weekly Paclitaxel and Breast Cancer  Apr 17, 2008
    Grade 2, 3, or 4 neuropathy was more frequent with weekly paclitaxel than with paclitaxel every 3 weeks (27% vs. 20%). Conclusions Weekly paclitaxel after standard adjuvant chemotherapy with doxorubicin and cyclophosphamide improves disease-free and overall survival in women with breast cancer. (New England Journal of Medicine)

    * Pill popping potential for harm  Apr 15, 2008
    In September, he wrote to Kaiser Permanente that a vitamin supplement he had regularly bought from the Kaiser pharmacy caused years of leg cramps, eventually diagnosed by a neurologist as vitamin B6-induced neuropathy. The supplement had 100mg of B6, or 50 times the recommended daily amount. (Taipei Times, Taiwan -- World)

    Vietnam veterans drawings may amaze: Listen to the Audio  Apr 15, 2008
    The leg was amputated because of an infected blister, which was attributed to neuropathy due to diabetes mellitus. Veterans Affairs doctors linked the diabetes to Agent Orange, a defoliating chemical used by the U.S. during Vietnam. (Durango Herald)

    Status of the E2007 (perampanel) Development Program  Apr 11, 2008
    The Phase II POC Study 227 in painful diabetic neuropathy (PDN) completed enrollment in March and is expected to provide top-line results in September 2008. A Phase III program will start soon afterwards, with regulatory submission for an indication in PDN planned in fiscal year 2010. (PR Newswire)

    Millennium Announces VELCADE(R) (Bortezomib) for Injection First-Quarter 2008 U.S. Net Sales  Apr 10, 2008
    Risks associated with VELCADE therapy include new or worsening peripheral neuropathy, hypotension observed throughout therapy, cardiac and pulmonary disorders, gastrointestinal adverse events, thrombocytopenia, neutropenia and tumor lysis syndrome. Women of childbearing potential should avoid becoming pregnant while being treated with VELCADE. Cases of severe sensory and motor peripheral neuropathy have been reported ... The long-term outcome of peripheral neuropathy has not been studied in... (PR Newswire)

    Potential for harm in dietary supplements  Apr 10, 2008
    In September, he wrote to Kaiser Permanente that a vitamin supplement he had regularly bought from the Kaiser pharmacy caused years of leg cramps, eventually diagnosed by a neurologist as vitamin B6-induced neuropathy. The supplement had 100 milligrams of B6, or 50 times the recommended daily amount. (International Herald Tribune -- Health)

    WEX Starts Phase III Trial of Tectin(TM) for Cancer Pain  Apr 9, 2008
    Moreover, the actual treatment of cancer can cause pain, with chemotherapy-induced peripheral neuropathy occurring in about half of patients receiving some types of chemotherapy. The global market for pain therapeutics used in cancer patients was approximately US$15. (CCNMatthews Press Releases)

    Former QPP worker fights for workers’ compensation  Apr 3, 2008
    According to the Minnesota Department of Health Web site, between December 2006 and November 2007, 13 QPP employees have been diagnosed with progressive inflammatory neuropathy, or PIN, a disorder with symptoms ranging from acute paralysis to weakness ... Basically, what we ve been saying is we believe that the number of people who have contracted this inflammatory neuropathy, essentially, was somehow probably triggered by contact with brain tissue from exposure to the plant, he said. (Austin Daily Herald, MN)

    Capsaicin Patch Reduces Pain from HIV Neuropathy  Apr 1, 2008
    While there is evidence that repeat use of low-dose topical capsaicin can provide meaningful relief for a number of painful conditions, HIV-related neuropathy does not appear to be one of them, prior research has shown ... "The most important finding is that the high-concentration capsaicin patch produced long-lasting (i.e. at least 3 months), significant pain relief in HIV-associated peripheral neuropathy with a good safety profile," Simpson told Reuters Health ... "This is an exciting time in... (MEDLINEplus)

    Shareholder Class Action Filed Against NeuroMetrix Inc. by The Law Firm of Schiffrin Barroway Topaz & Kessler, LLP  Mar 28, 2008
    In particular, The NC-stat System, the Company's neuropathy diagnostic system, is comprised of disposable single-use biosensors which are placed on the patient's body to perform nerve conduction studies. The Complaint alleges that, throughout the Class Period, defendants failed to disclose material adverse facts about the Company's financial well-being, business relationships, and prospects. (PR Newswire)

    Palmer reports no symptoms  Mar 26, 2008
    The symptoms included respiratory issues (especially difficulty breathing), severe headaches, bleeding in the sinus, heavy mucus production, peripheral neuropathy (tingling and numbness in extremities) and muscle aches. Superintendent Jim Hinson was hospitalized for eight days last summer treating the illness. (The Examiner)

    Motor Neuron Disease And Toxic Substances: Possible Link?  Mar 22, 2008
    They have discovered mutations in one key gene (neuropathy target esterase, or NTE) that cause a previously unknown type of inherited motor neuron disease. The discovery paves the way for better diagnosis and research on treatments. (Science Daily)

    Perioperative Eloxatin(R)-Based Regimen Significantly Reduced the Risk of Relapse Versus Surgery Alone in Eligible Colorectal Cancer Patients with Initially Resectable Liver Metastases  Mar 21, 2008
    2%), sensory neuropathy (Grade 3: 9. 6%), thrombocytopenia (Grade 3: 7. (PR Newswire)

    BioNumerik Pharmaceuticals and ASKA Pharmaceutical Co. Announce Results from Phase III Clinical Trial of Tavocept(TM)  Mar 18, 2008
    The primary trial endpoint was to evaluate Tavocept's potential for preventing and reducing the severity of sporadic and cumulative nerve damage, or neuropathy, experienced by patients receiving paclitaxel and cisplatin chemotherapy. The trial results indicate that the number of patients reporting either severe sporadic or cumulative neuropathy was approximately 50% lower in the Tavocept arm of the trial compared to the placebo arm. (PR Newswire)

    11 comment(s)  Mar 17, 2008
    The World Link: Vietnam vet fighting leukemia and the VA. Vietnam vet fighting leukemia and the VA. (Coos Bay-North Bend The World, OR)

    Twins Have Genetic Disorder Marked By Lack Of Sensation In Extremities  Mar 16, 2008
    The condition is known as hereditary sensory neuropathy type II, and doctors have not been able to identify the gene that causes it, let alone develop a plan to prevent or cure it. "They share a genetic burden," said Dr. Felicia Axelrod, a physician at New York University who has been treating the twins for nine years and is known as the country's pre-eminent authority on the condition. (FOX61, CT)

    Vietnam vet fighting leukemia and the VA  Mar 16, 2008
    Vietnam veteran Two Bears, formerly James Loveless, discusses on Feb. 28 his three-year battle to get treatment for cancer connected to his service during the war. Two Bears said he is dying of cancer caused by exposure to Agent Orange and other chemicals while serving in Vietnam. (Coos Bay-North Bend The World, OR)

    Computer software to detect glaucoma  Mar 7, 2008
    Glaucoma is a diseases of the optic nerve involving loss of retinal ganglion cells in a characteristic pattern of optic neuropathy. It is estimated that glaucoma affects 67 million people worldwide and Asians are prone to develop angle-closure glaucoma. (India Times)

    Motivation to lose weight comes in different forms  Mar 7, 2008
    I had neuropathy in my legs. I had diabetes. (Waterloo-Cedar Falls Courier)

    Light Therapy Doesn't Ease Diabetic Nerve Damage  Mar 5, 2008
    NEW YORK (Reuters Health) - A type of light therapy involving infrared energy is no more effective than sham therapy for treating nerve damage, or neuropathy, in people with diabetes, according to a study reported in the medical journal Diabetes Care. "Monochromatic infrared energy (MIRE) has been suggested to improve diabetic sensory neuropathy and even to prevent foot ulcers," write Dr. Lawrence A. Lavery and colleagues from Texas Aersity Health and Science Center College of Medicine in Temple... (MEDLINEplus)

    Cell Therapeutics, Inc. (CTI) Submits European Marketing Authorization Application for XYOTAX(TM)  Mar 4, 2008
    In the STELLAR 4 trial, single-agent XYOTAX resulted in comparable survival to gemcitabine or vinorelbine in first-line patients and, with the exception of neuropathy known to be associated with taxane therapy, demonstrated significant reduction in several clinically meaningful toxicities, such as severe neutropenia and infection, and in the requirement for transfusions and use of hematopoietic growth factor support. In addition to improved tolerability, XYOTAX offered more convenient... (PR Newswire)

    Test Helps Diabetics Detect Nerve Trouble  Mar 1, 2008
    In a study involving 156 diabetic patients and their health care providers, the in-home IPN test proved reliable and accurate for the diagnosis of diabetic nerve damage, also called peripheral neuropathy, which can cause numbness, pain, and tingling sensations in the feet ... "The results of the tests agree with those obtained by more complex tests used for the diagnosis of the diabetic neuropathy," Tentolouris said ... Currently there is no treatment for diabetic peripheral neuropathy, "and... (MEDLINEplus)

    Medical mystery solved in slaughterhouse  Feb 29, 2008
    Susan Kruse is one of the patients who suffered from the disease that's called progressive inflammatory neuropathy, or PIN. ... On January 31, the CDC gave a new name to the unique constellation of ailments: progressive inflammatory neuropathy, or PIN.. (CNN)

    Youngest Patient Worldwide To Have Auditory Implant In The Brain Stem  Feb 28, 2008
    26, 2003) UC Irvine neurologist Arnold Starr has pinpointed one of the causes of auditory neuropathy, a hearing disorder that prevents sound from reaching the brain in the normal. (May 17, 2007) Clinical research conducted in the Department of Communication Disorders at the University of Haifa revealed that some children who are born deaf "recover" from their deafness and do not require. (Science Daily)

    A Woman with Renal Failure and Stiffness of the Joints and Skin  Feb 21, 2008
    Peripheral Neuropathy. -->Respiratory Failure. (New England Journal of Medicine)

    Mis-typed label led to husband's death; hear audio  Feb 14, 2008
    Smith, a 46-year-old roofing contractor, suffered from chronic neuropathy pains in his legs and back. He had tried prescriptions for the painkillers Neurontin and Oxycontin. (USA Today -- Money)

    Burns Prompt Icy Hot Product Recalls  Feb 12, 2008
    "People or diabetics with delayed sensations -- people who have neuropathy in their hands or feet should never use these things --where they don't have normal sensations," said Cortmiglia. The makers of Icy Hot are asking consumers to immediately stop using the products and discard or return them for a refund. (NBCSandiego.com, CA)

    Managing Chronic Pain: When Does Morphine Become Less Effective?  Feb 8, 2008
    These data indicated that under conditions of chronic pain, endogenous opioid compounds prevent morphine from causing tolerance, inferring that the use of peripherally acting opioids for the prolonged treatment of inflammatory diseases such as chronic arthritis, inflammatory neuropathy, and cancer is not necessarily accompanied by opioid tolerance. The journal article "Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain" was published in the Journal of... (Science Daily)

    Worried About Family Or Friends Falling? New Guideline Identifies Those Most At Risk  Feb 8, 2008
    People with Parkinson's disease, peripheral neuropathy, weakness in the legs or feet, and substantial vision loss are also likely to fall. "People need to know that falls are preventable and there are simple tests to determine if you're at risk of falling," said Thurman. (Science Daily)

    New Guideline Urges Screening for Fall Risk  Feb 6, 2008
    Having fallen in the past year strongly predicts that a person will suffer another fall, and people with Parkinson's disease, peripheral neuropathy, weakness in the legs or feet, and substantial vision loss are also at increased risk for falls. The new guideline recommends doctors routinely ask patients about falls and use screening measures and mobility tests to assess whether a person is a risk of falling and needs prevention measures, such as starting a regular exercise program or eliminating... (MEDLINEplus)

    Paralysis Outbreak In Meat Workers...  Feb 5, 2008
    The illness is called Progressive Inflammatory Neuropathy (PIN) and its symptoms range from acute paralysis to gradual increase of weakness on both sides of the body, which in some cases happens over 8 days and in others over 213 days ... According to the MDH, 11 of the 12 workers affected showed evidence of axonal or demyelinating peripheral neuropathy (damage to nerve fibres and surrounding protective tissue) ... "Clinicians should provide CDC with information regarding swine slaughterhouse... (The Drudge Report)

    ...CDC Checking Link to Human Disease, Pig Brains  Feb 5, 2008
    If this theory is correct, the ailment -- for the moment called "progressive inflammatory neuropathy" -- resembles Guillain-Barre syndrome, an autoimmune condition that sometimes follows fairly benign infections, particularly those caused by an intestinal bacterium called Campylobacter. In the Minnesota cases, however, there appears to be no germ involved. (The Drudge Report)

    Workers fall ill after inhaling bits of pig brain  Feb 5, 2008
    If this theory is correct, the ailment, called "progressive inflammatory neuropathy," resembles Guillain-Barre syndrome, an autoimmune condition that sometimes follows fairly benign infections. Although far from proved, the theory makes enough sense that the Centers for Disease Control and Prevention, in Atlanta, has cast a net to about 25 other large-scale pig slaughterhouses in 13 states, seeking other cases. (News & Observer)

    Investigators name slaughterhouse illness  Feb 2, 2008
    The and Prevention issued a report Thursday summarizing the investigation so far that gives the condition a name -- progressive inflammatory neuropathy. Minnesota officials said they were broadening their investigation to thousands of former employees at the Quality Pork Processors Inc. plant in Austin, going back a decade to when a powerful compressed air system was installed to remove brain tissue from pig heads. (CNN -- Health)

    CDC pins name on slaughterhouse illness  Feb 2, 2008
    CDC is calling the condition progressive inflammatory neuropathy meaning something is triggering inflammation serious enough to damage nerves. Since December, 12 meatpackers in Austin, Minn. (Yahoo News -- Politics)

    Eisai Announces Change in U.S. Submission Schedule for E7389 New Drug Application  Feb 1, 2008
    Grade 3 peripheral neuropathy occurred in 6% of study participants, and there were no Grade 4 events. Eisai had planned to submit an NDA under Subpart H*, based on Phase II clinical trial data, to seek accelerated approval for E7389 as a third-line breast cancer treatment (monotherapy), but is precluded from doing so, because FDA approved another drug for this specific indication last October. (PR Newswire)

    Local man in need of kidney transplant  Jan 30, 2008
    He also suffers from diabetes and diabetic neuropathy, which causes a burning sensation in his feet. He said he feels like someone kicked me in the gut, all the time. (Somerset Daily American, PA)

    'At least you can kill people in a book'  Jan 29, 2008
    Doctors from the medical toxicology unit of Guy's Hospital in London later diagnosed that Brady was suffering from toxic peripheral neuropathy and also suspected that prolonged exposure to chemicals in the glues was very likely the cause of the nerve damage. Brady's fears were compounded when she did an online search and found that Bill Bowerman, Nike's co-founder, was diagnosed with peripheral neuropathy after experimenting with glues in the development of trainers. (Guardian Unlimited -- Books)

    Poniard Pharmaceuticals Announces Picoplatin Safety Data in Colorectal Cancer  Jan 28, 2008
    None of the patients treated with picoplatin exhibited a Grade 3 or higher neuropathy and only 9 of 45 patients (20 percent) experienced mild neuropathy. No neuropathy of Grade 2 or greater was observed in the 26 patients who received greater than or equal to 400 mg/m squared picoplatin ... Based on the evidence of a more attractive safety profile of picoplatin in this combination (FOLPI) compared to the standard of care regimen with oxaliplatin (FOLFOX) as well as clinical activity in the Phase... (PR Newswire)

    Pioneering spirit  Jan 24, 2008
    Susan Psalmonds, who has been confined to a wheelchair for the last year due to fibromyalgia neuropathy in her feet, also said winter poses a big challenge. In the summer time I really think nothing about going like from Wal-Mart over to Ross or ShopKo, she said. (Logan Herald Journal, UT)

    Study backs surgery to treat diabetes  Jan 23, 2008
    The patients also had been diagnosed with diabetes within two years of the surgery and did not suffer complications of diabetes, such as peripheral neuropathy. The Melbourne study was funded by Monash University. (Boston Globe)

    EpiCept Provides Update on Clinical and Regulatory Progress with Ceplene(TM) and EpiCept(TM) NP-1 Cream  Jan 23, 2008
    EpiCept also said today that it expects to unblind and announce the results from its Phase II "Neuracept" trial for EpiCept NP-1 cream in patients suffering from diabetic peripheral neuropathy (DPN) in the near future. This study was designed to collect data on 200 patients; because 231 patients were randomized in this trial, slightly more time than was previously anticipated is required to compile and analyze the data. (PR Newswire)

    * Stability isn't just psychological  Jan 22, 2008
    It can also result from overmedication with drugs like sedatives and anticonvulsants, vision disturbances and neuropathy or spinal cord disease that causes a loss of position sense in the legs. Vertigo, a false sense that the person or the surroundings are moving or spinning. (Taipei Times, Taiwan -- World)

    Health briefs for Jan. 21  Jan 22, 2008
    Brett Forman of The Physical Therapy Center will present Physical Therapy Interventions for Diabetic Neuropathy. This is a self-help group that can provide educational, social and emotional support for people affected by diabetes. (Rapid City Journal, SD)

    FDA Approves INTELENCE(TM) (etravirine) for HIV Combination Therapy  Jan 19, 2008
    The most common treatment-emergent adverse reactions (Grade 2-4) that occurred in greater than or equal to two percent of patients receiving an INTELENCE-containing regimen were diarrhea, nausea, abdominal pain, vomiting, fatigue, peripheral neuropathy, headache, rash, and hypertension. Additional Important Safety Information INTELENCE does not cure HIV infection or AIDS, and does not prevent passing HIV to others. (PR Newswire)

    Paula Abdul's Horrific Chronic Pain Battle  Jan 17, 2008
    For people with neuropathy, spinal cord injuries, rheumatoid arthritis and other diseases, chronic pain can last for decades and sometimes require drugs with side effects that can leave people drowsy, nauseous, or suffering from memory lapses to make life tolerable. Getting Acceptance. (ABC News)

    Mochida, Wyeth Enter License Agreement for Novel Pain Treatment  Jan 11, 2008
    It is hoped that TRPV1 antagonists will be effective in various pain conditions caused by inflammation or neuropathy with less side-effects than existing pain killers, which sometimes cause gastrointestinal disorders or renal disorders. Drug discovery research targeting TRPV1 receptor is highly competitive with several large pharmaceuticals companies engaged in research and development in this field. (JCN Network, Japan)

    Eli's Pies: Testament to a mother's love  Jan 9, 2008
    Kesser also believes Eli has auditory neuropathy, a condition in which the cochlea functions, but the auditory nerve has difficulty carrying the signal to the brain. To combat these problems, Eli is now scheduled to receive a cochlear implant. (Orangeburg Times and Democrat, SC)

    U.S. Sued Over Dropping of Benefits for Disabled  Jan 6, 2008
    The suit's plaintiffs include Eshetu Meri, 51, of Fairfax, a blind man who escaped from Ethiopia, where he was targeted for advocating democracy; Tasim Mandija, 80, of Philadelphia, a native of Albania who suffers from prostate cancer and neuropathy; and Rouzbeh Aliaghaei, 17, an Iranian who suffers from a rare genetic disorder that resulted in autism, seizures, mental retardation and an enlarged head. He came to the United States in 1998 when his parents escaped political persecution. (Yahoo News -- Disabilities and the Disabled)

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