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The current standard therapy of interferon and ribavirin is only effective in about 50 percent of cases and can cause major side effects, according to background information in the study. Recent research suggests that HVC may be "hitching a ride" along the lipoprotein life cycle, and that compounds and dietary supplements that influence lipoprotein metabolism may also affect HCV.. (Health-Finder)
Anti-fibrotic Mechanism Of A Chinese Medicinal Herb May Inspire Drug Development May 2, 2008
These effects are different from those of Western antifibrogenic drugs (such as interferon- gamma). The authors explain that the herbs used to prepare Cpd 861 have been used for thousands of years in Traditional Chinese Medicine, and the results of this research could allow for the development of effective antifibrogenic drugs from Chinese medicinal herbs. (Science Daily)
Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008 Apr 23, 2008
"These new studies confirm earlier data suggesting synergistic activity between nitazoxanide and peginterferon in genotype 4 patients and provide a first look at sustained virologic response in a limited number of genotype 1 patients," said Jean-Francois Rossignol, M.D., Director of the Romark Institute for Medical Research and discoverer of nitazoxanide. "These data also provide interesting insights into the mechanism of action of nitazoxanide and confirm previous findings related to its... (PR Newswire)
Health Disparities: Genetics Plays An Important Role In Cancer Detection, Prognosis Among Minorities Apr 19, 2008
Additionally, there was a distinctive interferon signature in gene over-expression in the African-American patients, which is associated with an immune system response against foreign invaders such as viruses. One puzzling finding: genes that activate the immune system and genes that suppress it were both more highly expressed in the African-American patients. (Science Daily)
Pill Reduces Relapses in Multiple Sclerosis Patients Apr 17, 2008
"The first-line treatments for MS, beta interferon and glatiramer acetate, reduce the relapse rate by only about 30 percent, so this is a significant development for people with MS," Comi said in a statement. The most commonly reported side effects of FTY720 were headache, flu and cold symptoms. (MEDLINEplus)
The Causes of Infection Apr 16, 2008
When a virus enters the cell it triggers the production of interferon: a substance which destroys many viruses. Major Micro-organisms Causing Infection. (Suite101.com)
Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040 Apr 16, 2008
The data showed that LOR-2040 significantly improved the anticancer efficacy of an important group of cytokine immunotherapeutic agents, including interferon alpha and interleukin-2, which have been used in the treatment of solid tumors. The findings expand the potential avenues for development of LOR-2040. (Canada Newswire)
Skin cancer: 8-year-old faces grown-up battle Apr 11, 2008
Now, she is being treated with interferon shots, given by her mother, Missy Halverson ... The doctors say we're doing the interferon shots as a precaution. (The Clarion-Ledger)
A time to heal - woman has wrestled with cancer Apr 9, 2008
Shortly after the diagnosis, she received intravenous treatments of interferon, a protein commonly used to treat hepatitis C. But what was supposed to be 20 days of treatment turned into two months. Her liver didn't react well to the treatment, and further treatments caused a blood clot. (Florida Times-Union)
Mechanism Underlying Multidrug Resistance In Fungi Discovered Apr 7, 2008
3, 2007) Interferon, the "superhero" cure for viral infections, may be a strong weapon in the battle against fungal infections in immunocompromised patients, according to a new article. Fungal infections. (Science Daily)
HILLARY BOMBSHELL ROCKS CAMPAIGN: 'OBAMA CAN'T WIN' Apr 3, 2008
Political Radar: Candidate Clinton to Richardson: 'Barack Obama Can't Win. Candidate Clinton to Richardson: 'Barack Obama Can't Win. (The Drudge Report)
USC researchers find new clues to risk of Hodgkin lymphoma Apr 2, 2008
"We found that lower levels of the protein interleukin-12, involved in fighting intracellular infections, increases susceptibility to young adult Hodgkin lymphoma," says Wendy Cozen, D.O., M.P.H, associate professor of preventive medicine at the Keck School of Medicine of USC. " Cozen is lead author on the study entitled, "Interleukin-2, interleukin-12, and interferon- levels and risk of young adult Hodgkin lymphoma," published in the April 1 issue of the journal, Blood. The study is... (EurekAlert!)
New Technique Will Speed The Development Of Vaccines, Study Shows Mar 28, 2008
In Brown s test, if the T cells recognized a protein, they started dividing and making interferon. Using the new procedure, Brown s team found T cells responded to about 20 proteins, including many that had never before been shown to stimulate a T cell response. (Science Daily)
Statement by InterMune, Inc. Regarding Justice Department Action Against Former Employee for Past Conduct Mar 19, 2008
March 18 /PRNewswire-FirstCall/ -- InterMune, Inc. (Nasdaq: ) issued the following statement regarding today's indictment of a former employee in connection with the promotional activities for Actimmune(R) (interferon gamma-1b) during a period that ended in June of 2003. "Today's indictment concerns conduct by a former employee who left the company more than four years ago. "In 2006, InterMune settled all government claims related to that conduct, without criminal sanctions against the company. (PR Newswire)
Former InterMune CEO W. Scott Harkonen Indicted for Wire Fraud and FDA Violations Mar 19, 2008
SAN FRANCISCO, March 18 /PRNewswire-USNewswire/ -- W. Scott Harkonen, M.D., the former CEO of InterMune Inc., was indicted on wire fraud and felony Food, Drug and Cosmetic Act charges for his role in the creation and dissemination of false and misleading information about the efficacy of InterMune's drug Actimmune (Interferon gamma-1b) as a treatment for idiopathic pulmonary fibrosis (IPF), the Justice Department announced today. The indictment alleges that Harkonen, a medical doctor, was the... (PR Newswire)
Medgenics Consolidates Corporate and R&D Operations into New Office Facility Mar 18, 2008
INFRADURE producing interferon-alpha (IFN- ) to treat hepatitis C ... Other potential areas include multiple sclerosis (interferon- ), haemophilia (Factor XIII), paediatric growth hormone deficiency (human growth hormone) and diabetes (insulin). (BusinessWire)
Scientists shine new light on inflammatory diseases Mar 17, 2008
In studies using human blood cells and mice, scientists examined the responses of macrophages during a two-day period after being stimulated with TNF. They found that macrophages secreted TNF and that then the TNF activated surface receptors on the macrophages themselves, spurring the cells into a low and sustained production of a protein called interferon-beta. This protein acted synergistically with TNF signals to induce 1) sustained expression of genes encoding inflammatory molecules and 2)... (EurekAlert!)
Health Department Gives Information on Hepatitis Mar 9, 2008
There is no treatment for acute Hepatitis B. Treatment of chronic Hepatitis B may involve medications such as the antiviral medication alpha interferon. Hepatitis B is prevented by using protective practices during sex and during contact with contaminated blood. (Missourian Publishing, MO)
Gene That Can Block The Spread Of HIV Discovered Mar 1, 2008
Barr and his team also prevented cells from turning on TRIM22 - provoking an interesting phenomenon: the normal response of interferon, a protein that co-ordinates attacks against viral infections, became useless at blocking HIV infection. "This means that TRIM22 is an essential part of our body's ability to fight off HIV. The results are very exciting because they show that our bodies have a gene that is capable of stopping the spread of HIV.". (Science Daily)
Everolimus (RAD001) Significantly Extends Progression-Free Survival in Advanced Kidney Cancer Patients After Failure of Other Targeted Therapy Feb 28, 2008 First Chikungunya Animal Model Created Feb 24, 2008 Probiotic Cuts Respiratory Illness Rates In Endurance Athletes, Study Suggests Feb 21, 2008 Biogen Idec issues Avonex warning Feb 21, 2008 Support group provides hope for MS victims Feb 20, 2008 Researchers create first chikungunya animal model Feb 20, 2008 Experimental HIV Vaccine Gets A Boost From '70s-era Discovery Feb 18, 2008 skewers the Fanjuls. Feb 17, 2008 Virus immunity 'created in lab' Feb 15, 2008 Genetic Breakthrough Supercharges Immunity To Flu And Other Viruses Feb 15, 2008 Probiotics 'protect top athletes' Feb 14, 2008 Good bugs ward off flu in elite athletes Feb 14, 2008 Biological Factors That May Drive Prostate Tumor Aggressiveness In African-American Men Found Feb 13, 2008 Silymarin does not affect virus activity or ALT levels in Feb 2, 2008 Vertexs lead drug telaprevir for the treatment of Hepatitis C will have to be monitored for the potential emergence of drug resistance, physicians say Feb 1, 2008 Hillary Says She Can Control Her Husband... Jan 31, 2008 Recently Discovered Cell Is Unexpected Player In Psoriasis Jan 31, 2008 Cells Use Velcro-like Mechanism To Keep Viruses From Spreading Jan 29, 2008 NEJM editorial on significance and limitations of new lupus gene expression research Jan 21, 2008 Schering-Plough Canada reports top-line results of first head-to-head study in Hepatitis C Jan 18, 2008 Genetic Differences May Help Explain Response To Multiple Sclerosis Treatment Jan 18, 2008 DNA Analysis Could Help Customize Treatments for MS Jan 18, 2008 Study finds why some benefit from MS drug Jan 15, 2008 Vertex Pharmaceuticals lead drug telaprevir may not be first-to-market; Scherings boceprevir may take market advantage Jan 15, 2008 Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread Jan 11, 2008 Shorter HCV treatment shows notable success Jan 3, 2008 Weight-based drugs to cure Hepatitis Dec 30, 2007 Matters of the heart Dec 27, 2007 New Combo Treatment Extends Kidney Cancer Survival Dec 25, 2007 Avastin Approved in Europe for First-Line Treatment of Patients With Advanced Kidney Cancer Dec 19, 2007 Helix BioPharma announces Q1 2008 financial results Dec 18, 2007 Helix BioPharma announces $16.9 million private placement of common shares Dec 17, 2007 New approach for attacking lupus identified Dec 17, 2007 Molecular 'Trip Switch' Shuts Down Inflammatory Response: Important Implications For Lupus Dec 14, 2007 Deadly Virus Strips Away Immune System's Defensive Measures Dec 14, 2007 Flu shot or not: That's the question Dec 13, 2007 Bile Acid May Improve Hepatitis C Therapy Response Dec 13, 2007 Drug Combo with Antibiotic May Slow Multiple Sclerosis Progression Dec 12, 2007 1st Kuwaiti woman MP sworn in Dec 11, 2007 Combo Treatment Including Antibiotics May Help MS Dec 11, 2007 Photo: New Data Show Gleevec(R) Halts Progression to Advanced Stages of Life-Threatening Form of Leukemia in Sixth Year of Treatment Dec 10, 2007 Gleevec, the targeted cancer pill, delivers more good news to patients Dec 10, 2007 Hemispherx Biopharma Receives Notice of Incomplete New Drug Application (NDA) Dec 8, 2007 EMD Serono launches easypod, new electronic growth hormone injection device Dec 7, 2007 Ebola and other tropical viruses Nov 30, 2007 Helix BioPharma Corp. announces management changes Nov 16, 2007 PEGINTRON(TM) and REBETOL(R) Approved in European Union for Retreating Hepatitis C Patients Who Failed Previous Pegylated or Non-Pegylated Interferon Therapy Nov 15, 2007 Hot on the Hep C trail Nov 12, 2007 PHARMA MARKET: First Out Of Gate, Nexavar Loses Ground Nov 11, 2007 Gene Expression Profiling Of Dengue Virus Infection In Cell Lines And Patients Nov 11, 2007 Leukemia drug proves safe and effective over the long term Nov 8, 2007 New genes linked to dengue identified Nov 8, 2007 Hepatitis C Treatment Reduces The Virus But Serious Liver Problems May Progress Nov 7, 2007 No Surprise That Vertex Has Competition Nov 7, 2007 Biogen Idec issues Avonex warning Nov 7, 2007 HGS unveils positive QOL results from Phase 2B trial of Albuferon for hepatits C Nov 6, 2007 Roche Issues Hepatitis Drug Data Nov 5, 2007 Gamma Interferon Could Aid Fight Against Fungal Infections Nov 4, 2007 Medical notes: Hepatitis C Nov 3, 2007 Vertex hepatitis C drug effective in trial Nov 3, 2007 First Studies Demonstrating Greater than Sixty Percent Sustained Viral Response Rates with Half the Standard Treatment Duration in Genotype 1 Chronic Hepatitis C Patients Nov 2, 2007 Allozyne lands $30M, hires veteran as CEO Oct 29, 2007 Helix BioPharma Corp. announces fiscal 2007 results Oct 27, 2007 Broccoli May Help Fight Skin Cancer Oct 25, 2007 Discovery Of New Antiviral Mechanism Promising For Hepatitis C Treatment Oct 23, 2007
In addition, prior therapy with Avastin(R) (bevacizumab)(3) and interferon was allowed. "Everolimus has the potential to greatly help patients with kidney cancer, especially in advanced stage who up to now have had no treatment options, as patients in the clinical trial on everolimus experienced a significantly longer period of time during which their cancer did not progress," said Daniel Vasella, Chairman and CEO of Novartis. (PR Newswire)
Gene At Intersection Of Stem Cells, Immunity Feb 27, 2008
When Dr. Margaret Goodell, professor of pediatrics and director of BCM's Stem Cells and Regeneration (STaR) Center, and her colleagues infected mice that lacked the gene interferon-inducible GTPase Lrg-47 with a bacteria akin to tuberculosis, they found that stem cells did not initiate the process of making blood cells to protect against the infection ... "What was surprising was that this gene was regulated by interferon gamma," she said ... Finding the interferon-inducible GTPase Lrg-47 in... (Science Daily)
tien F, Schilte C, Disson O, Brigitte M, et al. (2008) A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog 4(2): e29. (Science Daily)
The probiotic treatment doubled levels of interferon gamma, an important component of the body s immune response. Probiotics seem to increase systemic immunity, possibly by boosting the activity of T cells, say the researchers. (Science Daily)
Liver complications are associated with all of the beta interferon drugs, a class that includes Avonex. The FDA sees data from all the beta interferons," said Amy Ryan, the Biogen Idec spokeswoman. ''They're seeing increased hepatic injury and failure with all three products," she said, referring to Rebif and Berlex's Betaseron. (Yahoo News -- Multiple Sclerosis)
But my early interferon treatment has helped keep my MS under control and reduces the progression of the disease," she said. For Brown, the most difficult aspect of the disease is the occasional experience of not being able to complete simple functions. "At times, I am unable to walk or see," she said. "However, some people do not believe I have anything wrong with me. " In January 2005, Brown discovered an opportunity to meet and build relationships with others who share her experience when a... (Athens Banner-Herald)
CITATION: Couderc T, Chretien F, Schilte C, Disson O, Brigitte M, et al. (2008) A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog 4(2): e29. (EurekAlert!)
Decades ago, poly-IC had been found to induce a potent immune-simulating chemical called interferon, leading researchers to believe it might work as a stand-alone therapy for infections and cancer. As a primary therapy, it never lived up to its potential and quickly fell out of view. (Science Daily)
"I got it in a transfusion in 1976," he says, "and I've been in the care of the Mayo Clinic since. The virus count went up last year, and I was being treated with interferon. But the cure is worse than the damn disease. So I quit, but I was told to stay away from crowds.". When charities hosted parties at his Palm Beach mansion recently, Montgomery was nowhere to be seen. (The Palm Beach Post)
It works by stimulating production of the protein interferon, the cell's first line of defence against viruses ... The researchers knocked out two key genes in mice that repress production of interferon ... With these genes out of action, the mouse cells produced much higher levels of interferon, which effectively blocked viruses from reproducing. (BBC News -- Health)
Their process -- which could lead to the development of new anti-viral therapies in humans -- involved knocking out two genes in mice that repress production of the protein interferon, the cell's first line of defence against viruses. Without these repressor genes, the mouse cells produced much higher levels of interferon, which effectively blocked viruses from reproducing ... Interferon, in particular the type 1 interferons (IFN-; and IFN-2) suppress virus propagation. (Science Daily)
Blood tests taken from the athletes found doubled levels of interferon gamma, a chemical involved in the body's immune system, suggesting that the probiotics might somehow be helping the body to protect itself. The researchers said that the reason behind the study was to find ways to maximise the benefits to athletes getting ready for major events. (BBC News -- Health)
Dr Pyne said the probiotic treatment, sold in Australia as Probiomics PCC, also doubled levels of interferon gamma, an important component of the body's immune response. "This is an encouraging clinical outcome but we are still exploring the mechanisms to explain this," he said. (Sydney Morning Herald)
In addition, expression of a number of genes that are induced by a cytokine called interferon was found to be elevated in the African-American prostate tumor tissues. Interferon is produced by cells in response to various pathogens, including viruses. (Science Daily)
This information was somewhat surprising because these were patients with advanced liver disease who were clearly committed to conventional antiviral treatment for chronic hepatitis C, having been so treated previously, some on more than one occasion, but because they had failed to respond, were now willing to accept treatment again with pegylated interferon for another 3 and a half years ... The current recommended treatment for patients with HCV infection is combination therapy with pegylated... (EurekAlert!)
In Genotype 4 patients, the drug reported an impressive 79% SVR rate in interferon-naive patients ... Dr Roger Pomerantz, president of Tibotec Research and Development, who previously chaired the FDA panel for anti-virals, said the main goal is the decrease the treatment time patients are on interferon and ribavirin. (FT.com -- Markets)
Political Radar: Clinton Says She Can Control Her Husband. Clinton Says She Can Control Her Husband. (The Drudge Report)
Until now, one of these types of helper cells, called Th1, was believed to be a major contributor to psoriasis because it produces a molecule called interferon gamma, which is strongly associated with the disease ... It wasn t until the 12th week, however, that interferon gamma levels decreased, indicating that the Th1 cells had been downregulated. (Science Daily)
By watching particles of HIV as well as virus-like particles made from Ebola virus structural proteins, Bieniasz and first author Stuart Neil, a postdoc in the lab, found that an immune protein, known as interferon, actually instructs cells to tether enveloped viruses to the cell membrane like Velcro ... When they treated HIV-infected cells with interferon, the researchers found that they were able to almost completely eliminate replication of a mutant HIV-1 strain that lacked Vpu ... The virus... (Science Daily)
Her recent research has looked at the role of a family of molecules, the interferons, in lupus, their association with disease activity and the mechanisms of type I interferon production. Her recent findings from studies of lupus families have shown that increased interferon-alpha levels are a heritable risk factor for lupus. (EurekAlert!)
First Large Study Comparing Leading Hepatitis C Therapies Shows Similar Sustained Response Rates; Fewer Patients Relapsed Following PEGETRON(R) Therapy~ KIRKLAND, QC, Jan. 18 /CNW/ - Schering-Plough, a leader in hepatitis research, reported top-line results of the IDEAL (Individualized Dosing Efficacy vs. Flat Dosing to Assess optimaL pegylated interferon therapy) study, the first large, randomized, clinical study comparing the leading therapies for chronic hepatitis C: PEGETRON(R) (pegylated... (Canada Newswire)
17, 2008) By comparing the DNA of patients with multiple sclerosis whose symptoms are reduced by interferon beta therapy to the DNA of those who continue to experience relapses, researchers may have identified important genetic differences between the two, according to a new article ... A protein known as recombinant interferon beta is widely used to treat multiple sclerosis symptoms and possibly slow progression of the disease, according to background information in the article ... "Despite... (Science Daily)
Study suggests it could show who will respond best to interferon beta treatments ... Starting with 206 southern European patients with relapsing-remitting MS, the most common form of the disease, the researchers compared the DNA of patients whose symptoms were reduced by interferon beta therapy to the DNA of those who experienced relapses after such therapy ... "The beneficial outcomes of interferon beta therapy for patients in the relapsing-remitting phase of MS have been clearly shown," the... (MEDLINEplus)
The treatment involved uses a protein known as recombinant interferon beta to try to treat multiple sclerosis symptoms and perhaps slow the course of the disease, for which there is no known cure ... During the study, 99 of the patients were helped by interferon beta and 107 were not. (Scientific American)
PROVE III is a Phase IIb clinical trial of telaprevir-based combination therapy in patients with genotype-1 HCV who have not achieved a SVR with a previous pegylated interferon-based treatment ... Two large Phase II trials of Vertexs drug telaprevir dosed in combination with Pegylated Interferon and Ribavirin showed SVR rates of 61% and 65 ... The current standard of treatment consists of a daily oral dose of ribavirin, which is available as a generic, along with a weekly injection of alpha... (FT.com -- Markets)
Using antibodies to IDO, they didnt find any IDO expression until they treated the cells with interferon to mimic the conditions in the lymph nodes. The tumor cells were then able to make the enzyme. (EurekAlert!)
Two new randomized controlled trials show that treating Hepatitis C (HCV) with peginterferon and ribavirin for shorter durations can yield success rates similar to those from longer treatment lengths, with cost-savings and lower risk of serious side effects ... HCV genotype is the single most important predictor of a patients outcome after treatment with peginterferon and ribavirin ... Meanwhile, researchers in Norway led by Olav Dalgard conducted a randomized controlled trial of 428 patients... (EurekAlert!)
The study of over 5,000 patients with hepatitis C virus (HCV) showed that the treatment with weight-based REBETOL (ribavirin, USP) (RBV) in combination with pegylated interferon (PEG-IFN) alfa-2b, resulted in higher rates of sustained virologic response (SVR) and lower relapse rates, as compared to combination therapy using a flat dose of RBV 800 mg/day. The response of such dose was a lot better in patients suffering from the most difficult-to-treat form of the disease, genotype 1 HCV.. (India Times, India -- Health/Science)
anthracycline (doxorubicin and daunorubicin - common cause), cyclophos-phamide, paclitaxel, 5-FU, herceptin, monoclonal antibody trastuzumab, interferon ... interferons, interlukins and anti depressants. (Express Pharma)
Avastin plus interferon almost doubled patients' time without disease progression, study found ... FRIDAY, Dec 21 (HealthDay News) -- A combination treatment with two drugs, Avastin (bevacizumab) plus interferon, extends the life of patients with kidney cancer, European researchers report ... In a phase III trial, Dr. Bernard Escudier from the Institute Gustave Roussy in Villejuif, France, and colleagues randomly assigned 649 patients with kidney cancer to receive Avastin and interferon or... (MEDLINEplus)
Avastin offers patients the chance to live twice as long without their disease advancing BASEL, Switzerland, Dec. 19 /PRNewswire/ -- Avastin (bevacizumab), Roche's innovative anti-cancer drug, was approved today in Europe for the first-line treatment of patients with advanced renal cell cancer (RCC) in combination with interferon (IFN), the current standard of care. Kidney cancer, known as renal cell carcinoma (RCC) is a disease that kills over 100,000 people per year world-wide(1). (PR Newswire)
Research and development expenditures related to Topical Interferon Alpha-2b remained relatively flat, with expenditures from the late stage phase II German study during the first quarter of fiscal 2007 being offset by expenditures in the first quarter of fiscal 2008 relating to patient enrollment in the phase II trial in Sweden along with costs associated with patent filings and consulting services. The Company expects to increase its Rding through the remainder of fiscal 2008, as its Topical... (PR Newswire)
Helix's product development initiatives include its Topical Interferon Alpha-2b and its novel L-DOS47 new drug candidate. Helix is listed on the TSX under the symbol "HBP" and quoted on the Frankfurt, Berlin, Munich and Stuttgart Stock Exchanges under the same symbol. (PR Newswire)
Because abnormally high levels of interferon-alpha can lead to lupus, researchers have developed drugs that block interferon ... Interferons have two major functions ... We thought if we could control the functions of the interferons, that would lead to new therapeutic approaches where you could block specifically some of their functions, but not others. (EurekAlert!)
An essential stimulator of inflammation -- the type 1 interferon receptor (IFNAR) -- and its associated transcription factor, STAT1, turn on expression of Axl, a TAM receptor ... "It's a cool thing. TAM receptors can't work without binding to the interferon receptors, so that means that a pro-inflammatory signaling system is co-opted and re-directed to drive the expression of genes that will shut it down.". (Science Daily)
One way the immune system responds to viral invasion is increased production of a class of protein hormones known collectively as interferon. In recent years, Virgin's lab has shown that one result of this spike in interferon levels is that the antiviral molecule known as ISG15 (for interferon-stimulated gene 15) is produced and attached to many different cell proteins. (Science Daily)
Marianne L. Garvens wrote on Dec 13, 2007 7:20 AM:" Vaccines work by introducing antigens (genetic-markers) by injecting/introducing genetic fragments, inactive/dead, modified-live and/or live viruses or bacteria into your body to make you a little sick, because you need to get a little sick in order to develop immunoglobulins (white blood cells/T-cells) to attack the source of an active infection. [Elevating levels of interferon will improve immune response, thats why some cancer... (Freeport Journal-Standard, IL)
NEW YORK (Reuters Health) - A bile acid - called ursodeoxycholic acid -- may improve response to treatment in patients with chronic hepatitis C virus (HCV) who don't respond to standard therapy with interferon and ribavirin, Japanese researchers report in the medical journal Gut. Ursodeoxycholic acid is a secondary bile acid that breaks down fat, and reduces the amount of cholesterol produced by the liver and absorbed by the intestines. (MEDLINEplus)
Interferon therapy plus doxycycline reduced number of brain lesions, study finds ... 5) with relapsing-remitting MS who'd been taking interferon for at least six months and were experiencing symptoms and developing new brain lesions ... For four months, the patients took 100 milligrams daily of the antibiotic doxycycline in addition to their interferon therapy. (MEDLINEplus)
Taking a common antibiotic along with standard interferon treatment may be effective in helping some people with multiple sclerosis, a small preliminary study suggests. Scientists have created an "autistic mouse" after replacing a normal gene in its body with a mutated one. (Yahoo News -- Kuwait)
Many patients with relapsing-remitting MS who take interferon, a medication that boosts the immune system and fights viruses, still experience relapses and may continue to develop new areas of damaged brain tissue (lesions) visible on magnetic resonance imaging (MRI) ... 5) with relapsing-remitting MS who had been taking interferon for at least six months and were experiencing symptoms and developing new brain lesions ... For four months, participants took 100 milligrams daily of the antibiotic... (Newsmax)
To view the Multimedia News Release, go to: Results of the International Randomized Interferon versus STI571 (IRIS) study reveal that after two years of treatment the rate of disease progression continued to decline and fell to 0% in the study's sixth year ... There are two arms to the study: one group of patients received Gleevec 400 mg per day, while the other received a target dose of interferon (IFN) of 5 MIU/m2/day in combination with cytarabine (Ara-C) 20 mg/m2/day for 10 days each month... (PR Newswire)
Six-year results of the International Randomized Interferon versus STI571 (IRIS) study for which Druker served as principal investigator, demonstrated that continuous treatment with Gleevec produced a declining rate of relapse over time. The downward trend in the risk of disease progression while on Gleevec has continued since year two of the study. (EurekAlert!)
In October, 2007, the Company's New Brunswick facility passed a biannual FDA inspection relating to its fully commercialized interferon product (Alferon N Injection(tm)) with no infractions or citations. The Company will continue to move forward, as originally planned, with its regulatory filings in various countries outside the United States, while continuing its efforts to meet all the FDA requirements. (Primezone Releases)
The company has strong market positions in neurodegenerative diseases, with Rebif (interferon beta-1a), as well as in endocrinology, with Saizen (somatropin (rDNA origin) for injection), Serostim (somatropin (rDNA origin) for injection) and Zorbtive (somatropin (rDNA origin) for injection). About Merck KGaA, Darmstadt, Germany. (EurekAlert! -- Business News)
There is still no treatment for Ebola readily available - no standard anti-viral therapies such as interferon have any effect. A vaccine has been produced that was 100% effective in protecting a group of monkeys from the disease, but attempts to replicate the success in humans have so far proved unsuccesful. (BBC News -- Health)
At Helix, Mr. Docherty has been instrumental in developing the Company's lead product candidate, Topical Interferon Alpha-2b, in addition to supporting the Company's growing investor and media relations initiatives ... Helix's product development initiatives include its Topical Interferon Alpha-2b and its novel L-DOS47 new drug candidate ... Helix's actual results could differ materially from those anticipated in these forward-looking statements and information as a result of numerous risks,... (PR Newswire)
First and Only Peginterferon Therapy Approved for Retreating Both Hepatitis C Relapsers and Nonresponders KENILWORTH, N.J., Nov. 15 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: ) today announced that the European Commission on October 30 approved 48-week standard-dose PEGINTRON(TM) (peginterferon alfa- 2b, 1. 5 mcg/kg once weekly) and REBETOL(R) (ribavirin, 800 - 1,400 mg daily) combination therapy for retreating adult patients with chronic hepatitis C whose prior treatment with... (PR Newswire)
Dennis G. Hendricks Alice Leung, president and CEO of Intarcia Therapeutics, demonstrates the subcutaneous placement of the company s implant, OmegaDUROS, that delivers omega interferon round-the-clock for three months to hepatitis C patients. Related News. (San Jose Business Journal, CA)
Doctors view Nexavar and other new drugs as improvements over common kidney- cancer treatments, such as interferon and interleukin. The long-term prognosis for people with advanced RCC, however, remains grim. (CNNMoney.com)
From the activated genes, the researchers identified three pathways common to in vitro and in vivo infection; the NF-kappaB initiated immune pathway, the type I interferon pathway, and the ubiquitin proteasome pathway. They next found that inhibiting the ubiquitin proteasome pathway, or activating the type I interferon pathway, resulted in significant inhibition of viral replication whereas inhibiting the NF-kappaB initiated immune pathway had no effect on viral replication. (Science Daily)
Prior to enrollment, all study participants had experienced either treatment failure or intolerance with interferon alpha, which was the standard of care for CML at the time the study was initiated. The long-term follow-up results of imatinib in CML post interferon failure reassure us of the high efficacy of the drug and its safety, stated Hagop Kantarjian, MD, the lead author on the study and Chairman and Professor of the Leukemia Department at the University of Texas M.D. Anderson Cancer... (EurekAlert!)
From the activated genes, the team identified three pathways common to in vitro and in vivo infection; the NF-kappaB initiated immune pathway, the type I interferon pathway, and the ubiquitin proteasome pathway. In the study, the researchers found that inhibiting the ubiquitin proteasome pathway, or activating the type I interferon pathway, resulted in significant inhibition of viral replication whereas inhibiting the NF-kappaB initiated immune pathway had no effect on viral replication. (India Times, India -- Health/Science)
7, 2007) Patients with chronic hepatitis C and advanced liver disease who did not respond to previous standard therapy experienced significant decreases in their liver enzymes, viral levels, and liver inflammation following treatment with long-term pegylated interferon ... "The HALT-C trial unequivocally demonstrated that maintenance therapy with peginterferon does not prevent progression of liver disease among patients who have failed prior treatments," said James Everhart, M.D., project... (Science Daily)
For example, the standard of care for current hepatitis C treatment is Roche's interferon Pegasys. In one study with Pegasys testing two different doses, 82% and 63% of genotype 4 patients were cured of their hepatitis C, whereas only 51% and 40% of genotype 1 patients were cured, so clearly genotype 4 patients responded to treatment better than genotype 1 patients. (MSNBC -- Business)
Liver complications are associated with all of the beta interferon drugs, a class that includes Avonex. The FDA sees data from all the beta interferons," said Amy Ryan, the Biogen Idec spokeswoman. ''They're seeing increased hepatic injury and failure with all three products," she said, referring to Rebif and Berlex's Betaseron. (Yahoo News -- Multiple Sclerosis)
Albuferon was associated with fewer missed work days and less impairment of quality of life on treatment than peginterferon alfa-2a. ROCKVILLE, Maryland November 5, 2007 Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced the final quality-of-life results from a Phase 2b clinical trial of the investigational drug, Albuferon (albinterferon alfa-2b), in combination with ribavirin in treatment-naive patients with genotype 1 chronic hepatitis C. The study demonstrated that patients in... (EurekAlert!)
Presenting results at the American Association of the Study of Liver Diseases (AASLD) meeting in Boston, the Swiss drugmaker said its investigational hepatitis C drug R1626 showed promising antiviral activity in the phase IIa trial when given with Pegasys (peginterferon alfa-2a) and Copegus. The aforementioned Roche drugs are used together to treat adults with chronic hepatitis C whose liver still works normally and who haven't been previously treated with an interferon alpha. (TheStreet.com)
3, 2007) Interferon, the superhero cure for viral infections, may be a strong weapon in the battle against fungal infections in immunocompromised patients, according to an article in the November issue of Microbiology Today ... Now, scientists believe gamma interferon, a protein molecule produced by human cells in response to infections, may help to fight fungal infections ... Gamma interferon enhances the mechanisms of these cells to make them more potent killers of fungi. (Science Daily)
Currently, hepatitis C is treated with a combination of two drugs, interferon alpha and ribavirin. About 40% of patients respond to this "combination" therapy. (BBC News -- Health)
In a mid-stage trial conducted in the United States known as PROVE 1, 61 percent of 79 patients who took telaprevir in combination with the standard treatments, pegylated interferon and ribavirin, saw the virus fall to undetectable levels in their blood and remained undetectable six months after treatment was stopped. But 13 percent of patients discontinued the trial in the first 12 weeks because of side effects. (San Diego Union-Tribune -- Business)
Two Large Phase 2 Trials of Telaprevir, an Investigational Hepatitis C Protease Inhibitor, Dosed in Combination with Pegylated Interferon and Ribavirin Show SVR Rates of 61% and 65 ... BOSTON--(BUSINESS WIRE)--Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced results from interim analyses of PROVE 1 and PROVE 2, two large Phase 2b clinical trials evaluating the investigational hepatitis C protease inhibitor telaprevir (VX-950), dosed in combination with pegylated interferon and... (BusinessWire)
Allozyne will initially focus on producing an improved version of interferon beta, which is widely used to treat multiple sclerosis (MS), a neurological disease that can produce debilitating symptoms. MS treatments represent a $4 billion market, and interferon drugs make up 75 percent of that, said Chhabra ... Using the techniques developed at CalTech, Allozyne will seek to develop a modified version of interferon beta that is more effective, tolerable and long-lasting than existing drug... (Puget Sound Business Journal, WA)
During the 2007 fiscal year, the Company continued to make progress with its clinical (Topical Interferon Alpha-2b) and pre-clinical (L-DOS47) development programs ... HIGHLIGHTS - Topical Interferon Alpha-2b - Announced positive Phase II clinical results with Topical Interferon Alpha-2b in patients with HPV-induced low-grade squamous intraepithelial lesions ("LSIL") - Initiated enrollment in Phase II clinical trial with Topical Interferon Alpha-2b in patients with HPV-induced ano-genital warts... (PR Newswire)
"The same thing happens with interferon, which we use for melanoma. It boosts the natural killer cells," Trisal explained. The findings do need to be replicated, Talalay noted. (Health-Finder)
The only approved therapy for Hepatitis C is alpha-interferon, a protein produced by animal cells when invaded by viruses that induces healthy cells to manufacture enzymes that counter the infection. Often alpha-interferon is used in combination with an antiviral drug called ribavirin ... However, only 40 to 80 percent of patients respond to this therapy and about half of those who do respond relapse once interferon treatments are stopped. (Science Daily)
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