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This study found "no evidence to support the commonly held assumption that growth hormone treatment improves health-related quality of life.". In addition, another study found no significant evidence that recombinant growth hormone treatment affects psychological well-being or self-esteem in these children. (Scientific American)
Researchers To Develop Method For Treating Heart Failure And Depression Simultaneously Jul 31, 2007
The study is designed to obtain the necessary feasibility and clinical data required to plan a large-scale trial, which will compare the impact of a "blended" depression/heart failure care management programs vs. traditional heart failure care management program on cardiovascular morbidity and mortality, health-related quality of life, mood symptoms, health care costs and a variety of other outcomes of interest. Heart failure affects 5 million Americans, with more than 550,000 newly diagnosed... (Science Daily)
Depression often untreated in Parkinson's disease patients Jul 10, 2007
In another study based on data collected at the University of Alberta and funded by the Canadian Institutes of Health Research, Dr. Richard Carmiciolo has also found that depressive symptoms were the largest influence on health-related quality of life in older people with Parkinsons disease. While we found that depression is common in early Parkinsons disease diagnosis, weve also uncovered that depressive symptoms have the most significant influence on health-related quality of life in older... (EurekAlert!)
SARS Survivors Recover From Physical Illness, But May Experience Mental Health Decline Jun 27, 2007
"The longer-term physical and psychological consequences of SARS were not reported until recently." Investigations of the disease have focused on lung function, distance walked in six minutes and health-related quality of life ... "We have shown that most SARS survivors have pulmonary and functional recovery from their acute illness. However, one year after discharge from hospital, health-related quality of life remained lower than in the general population, and patients reported important... (Science Daily)
SARS May Have Left Mental Scars Jun 26, 2007
"We have shown that most SARS survivors have pulmonary and functional recovery from their acute illness. However, one year after discharge from hospital, health-related quality of life remained lower than in the general population, and patients reported important decrements in mental health. These findings are reflected in the notable utilization of psychiatric and psychological services in the one-year follow-up period," the study authors wrote. Family and friends who acted as caregivers for... (Health-Finder)
Aftereffects of Prostate Cancer Treatments Vary Jun 9, 2007
Litwin, at the University of California, Los Angeles, and colleagues evaluated general and disease-specific health-related quality of life in 580 men after being treated for localized prostate cancer with surgical removal of the prostate (radical prostatectomy), or external beam radiation therapy, or brachytherapy. The type of treatment did not influence general health-related quality of life, the researchers report, but there were several differences in specifics. (MEDLINEplus)
Seizure Status After Surgery Key to Quality of Life Jun 6, 2007
But if the surgery doesn't eradicate seizures and memory loss develop, patient experience s a decline in health-related quality of life, Dr. John T. Langfitt of the University of Rochester in New York and colleagues report. It's possible that people have an easier time compensating for memory loss, for example by keeping lists, than coping with the handicapping effects of seizures, Langfitt and his colleagues suggest in their report, published in the June 5th issue of Neurology. (MEDLINEplus)
Results of VEGF Trap (Aflibercept) Highlighted at ASCO 2007 Annual Meeting Jun 3, 2007
Secondary endpoints are time to progression (TTP), progression-free survival (PFS), overall survival (OS), CA-125 protein level reduction, and time to CA- 125 progression, as well as safety, pharmacokinetics, immunogenicity and health-related quality of life measures. From June 2006 to April 2007, 162 patients were randomized and evaluated for efficacy from 44 centers in 12 countries (Europe, Canada, and the United States). (PR Newswire)
Wednesday's Stocks to Watch May 30, 2007
Data from the 164-patient, double-blinded, randomized study demonstrated a significant improvement in health-related quality of life as reported by patients following a 28- 000005A8 day treatment with the drug compared with a placebo. International Business Machines Corp. () said it has repurchased $12. (Fox News)
Drug Treatment Slows Decline In Lung Function In COPD Patients, TORCH Study Finds May 25, 2007
However, treatment with the combination treatment did result in significantly fewer COPD flareups and improved health-related quality of life and lung function, as compared with placebo. This research was presented at the American Thoracic Society 2007 International Conference, on Tuesday, May 22. (Science Daily)
Living With Cancer: Keeping Pain And Fatigue Under Control May 24, 2007
Participants in this study from New Mexico and western Washington were asked to score their lev-els of pain and physical sensation, hormone-related symptoms, sexual interest/dysfunction, fatigue and physical health-related quality of life at 6, 29 and 39 months post-diagnosis ... The authors expected to see higher levels of activity being related to fewer physical symptoms and higher health-related quality of life ... Physical activity, long-term symptoms and physical health-related quality of... (Science Daily)
Data showed improved quality of life and patient satisfaction with SYMBICORT May 23, 2007
Wilmington, DE May 22, 2007 New data demonstrated that the combination asthma therapy, SYMBICORT (budesonide/formoterol fumarate dihydrate), led to significant improvements in health-related quality of life (HRQL) and greater patient-reported satisfaction with asthma treatment, versus its monocomponents (budesonide or formoterol) or placebo. The results from these two 12-week randomized, double-blind trials were presented at the American Thoracic Society (ATS) 2007 International Conference... (EurekAlert!)
Lymphoma Survivors' Quality of Life Often Reduced May 16, 2007
"Non-Hodgkin lymphoma survivors still have poorer health-related quality of life years after diagnosis, but in survivors of other cancers, this is not always the case," Mols told Reuters Health ... Those who'd received chemotherapy seemed to fare even worse -- showing poorer psychological well-being and a lower health-related quality of life than survivors who'd received other treatments. (MEDLINEplus)
IMS updated recommendations on postmenopausal hormone therapy May 16, 2007
In women with bilateral oophorectomy or adrenal failure, androgen replacement has significant beneficial effects, in particular on health-related quality of life and sexual function. BENEFITS OF HORMONE THERAPY. (EurekAlert!)
Protelos(R): First Osteoporosis Treatment to Show Long-Term, Sustained Efficacy and Quality of Life Improvement May 6, 2007
Quality of life(2) Vertebral fractures can lead to a significant downturn in patients' health-related quality of life (HRQoL). The SOTI (Spinal Osteoporosis Therapeutic Intervention) study, a double-blind placebo-controlled study carried out in 1649 postmenopausal osteoporotic women, measured the impact of Protelos on HRQoL for four years. (Canada Newswire)
Promising Drug Fails To Improve COPD Symptoms May 5, 2007
The questionnaire, which was the primary endpoint, assesses health-related quality of life in patients with functionally limiting chronic lung disease. There were also no differences among the three groups in secondary efficacy endpoints as measured by FEV1, 6-minute walk distance, the transition dyspnea index and the number of exacerbations requiring a doctor or hospital visit. (Science Daily)
Patch for Overactive Bladder Seen Useful May 1, 2007
Dr. Peter Sand from Northwestern University, Feinberg School of Medicine, Evanston, Illinois and associates evaluated the changes in health-related quality of life in 2,592 adults with overactive bladder during treatment with the oxybutynin skin patch ... Treatment with transdermal oxybutynin was associated with clinically meaningful improvements in all domains of a standard questionnaire used to measure health-related quality of life, the researchers report. (MEDLINEplus)
Human Genome Sciences Reports Positive Interim Results of Phase 2b Trial of Albuferon(R) Apr 15, 2007
-- Based on the SF-36 Heath Survey, patients in the Albuferon 900 Q2 treatment group reported less impairment of health-related quality of life, compared with patients in the Pegasys treatment group, as measured by both physical component and mental component SF-36 summary measures at all time-points throughout the 48-week treatment period. -- At Weeks 12 and 24, fewer working patients in the Albuferon 900 Q2 treatment group reported missing 7 days or more of work during the previous month, vs.... (PR Newswire)
Radiotherapy for Glioblastoma in the Elderly Apr 12, 2007
The primary end point was overall survival; secondary end points were progression-free survival, tolerance of radiotherapy, health-related quality of life, and cognition. Results We randomly assigned 85 patients from 10 centers to receive either radiotherapy and supportive care or supportive care alone. (New England Journal of Medicine)
Prostate Cancer Treatment Side Effects Differ Apr 3, 2007 Heavy Men May Be Less Apt to Commit Suicide Mar 15, 2007 Image Concerns Tied to Depression in Arthritis, Lupus Patients Mar 3, 2007 Improving Quality Of Life For Patients With Cirrhosis Mar 2, 2007 Exercise on Prescription: Trial protocol and evaluation of outcomes Mar 2, 2007 Remicade therapy shown to improve productivity in patients treated for chronic plaque psoriasis Feb 3, 2007 Medica Foundation awards Courage Center $30,000 grant Jan 24, 2007 Poor Sleep Tied to Poor Behavior in Preschoolers Jan 24, 2007 Combo Therapy Cuts Complications of Severe COPD Jan 18, 2007 Young Asthmatics Reliably Describe Health Status Jan 13, 2007 JRRD releases single-topic issue focused on vision rehabilitation Jan 12, 2007 Total Rather Than Good Asthma Control Seen Best Jan 6, 2007
The drop in health-related quality of life immediately after treatment was less pronounced with seed therapy compared with surgery, the team found. However, from 6 to 24 months, surgery was associated with a better quality of life. (MEDLINEplus)
Mind Over Pain Mar 30, 2007
Mindfulness-Based Stress Reduction And Health-Related Quality Of Life In. A Heterogeneous Patient Population. (Suite101.com)
Mental health-related quality of life was determined with a standard survey in a subset of 1,829 men in 1998 ... Mukamal's team also found that mental health-related quality of life improved as BMI increased. (MEDLINEplus)
The study, published in the March issue of the journal Arthritis Care rch, examined 157 patients with lupus, newly-diagnosed rheumatoid arthritis, or chronic rheumatoid arthritis who filled out questionnaires designed to assess the patients' disability, health-related quality of life (HRQOL), psychological distress, and coping strategies. The results showed that all the patients had increased levels of psychological distress and that the lupus patients' HRQOL was negatively affected. (MEDLINEplus)
Article: "Lactulose Improves Cognitive Functions and Health-Related Quality of Life in Patients with Cirrhosis Who Have Minimal Hepatic Encephalopathy," Srinivasa Prasad, Radha K. Dhiman, Ajay Duseja, Yogesh K. Chawla, Arpita Sharma, Ritesh Agarwal, Hepatology; March 2007 (DOI: 10. 1002/hep. (Science Daily)
Physiological measures used were maximal oxygen uptake (VO2max), glycosylated haemoglobin (HbA1c), bodyweight, and BMI. Patient-reported measures used were physical activity, health-related quality of life, amount and intensity of exercise, compliance with national guidelines for physical activity, and physical fitness. The validation of the cycle ergometer test found a strong correlation between maximal work capacity and VO2max, and acceptable test-retest reliability at group level. (BioMed Central)
Increased productivity scores paralleled significant improvements in the role-physical domain (RP) and role-emotional domain (RE) scores of SF-36, an eight-domain questionnaire widely used to assess patient health-related quality of life. In EXPRESS II, at baseline, RP scores in the REMICADE 3 mg/kg, REMICADE 5 mg/kg and placebo groups were relatively low compared with the general population (47. (EurekAlert!)
According to a press release, the project's effectiveness will be measured in terms of improved function, health-related quality of life, and medical utilization costs. Minneapolis-based Courage Center, a nonprofit rehabilitation and resource center, offers rehabilitation therapies, transitional rehabilitation, pain management, vocational and community-based services, and camping and sports and recreation programs. (Twin Cities Business Journal, MN)
NEW YORK (Reuters Health) - Preschool-aged children with sleep problems are more likely to have behavior problems and poor health-related quality of life than kids without sleep difficulties, a new study from Australia shows ... Sleep problems in school-aged kids have been shown to increase the risk of behavior problems, poor performance in school and low health-related quality of life, the researchers note. (MEDLINEplus)
"In particular, they greatly contribute to the decline of health-related quality of life, increase symptoms and breathlessness, speed progression of the disease and increase the risk of mortality. In addition, exacerbations induce enormous economic costs. They can occur at any stage of the disease but become more frequent as lung function impairment worsens," Kardos said. Smoking is the primary cause of COPD, which results from chronic bronchitis and emphysema. (MEDLINEplus)
"Whether to collect patient-reported data (such as health status or health-related quality of life) from parents or children is an important question in both pediatric research and clinical practice," Dr. Lynn M. Olson, of the American Academy of Pediatrics, Elk Grove Village, Illinois, and colleagues write. Parents and children may have different views on the impact of disease, the authors note, and some aspects may be difficult for parents to assess. (MEDLINEplus)
We compared data from pilot studies involving patients' self-reported health-related quality of life after participation in two Department of Veterans Affairs (VA) Blind Rehabilitation Center (BRC) programs. Southwestern BRC researchers in Tucson, Arizona, administered the National Eye Institute Visual Functioning Questionnaire (NEI VFQ) exactly as directed, while researchers at the VA hospital BRC in Hines, Illinois, modified the directions to consider use of low-vision devices. (EurekAlert!)
"These results confirm that near-normal health-related quality of life can be achieved when treatment aims for total control of asthma," the researchers conclude. SOURCE: European Respiratory Journal, January 2007. (MEDLINEplus)
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