XOMA to Announce First Quarter 2008 Financial Results and Host Conference Call on Monday, May 12 May 5, 2008
XOMA's technologies and experienced team have contributed to the success of marketed antibody products, including RAPTIVA(r) (efalizumab) for chronic moderate to severe plaque psoriasis and LUCENTIS(r) (ranibizumab injection) for wet age-related macular degeneration. The Company has a premier antibody discovery and development platform that incorporates leading antibody phage display libraries and XOMA's proprietary Human Engineering(tm) and bacterial cell expression technologies. (Primezone Releases)
Hormone Use Related To Lower Risk Of Macular Degeneration In Postmenopausal Women Apr 18, 2008
17, 2008) Women who take postmenopausal hormones appear to have a lower risk of developing advanced stages of the eye disease age-related macular degeneration, especially if they had also taken oral contraceptives in the past, according to a new report ... Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness among older adults, affecting 1 ... 30, 2007) With 8 million people at high risk for advanced age-related macular degeneration, researchers discovered... (Science Daily)
Antioxidant Users Don't Live Longer, Analysis Of Studies Concludes Apr 16, 2008
11, 2007) A diet rich in antioxidant vitamins and minerals does not seem to prevent the degenerative eye disease known as age related macular degeneration. Age related macular degeneration is the leading cause. (Science Daily)
Hormone Replacement May Cut Risk for Age-Linked Eye Disease Apr 16, 2008
MONDAY, April 14 (HealthDay News) -- Postmenopausal women who take hormones have a lower risk of developing advanced age-related macular degeneration, especially if they took oral contraceptives in the past, a U.S. study finds. Age-related macular degeneration (AMD) affects 1. (MEDLINEplus)
Genentech Net Up, Key Drug's Growth Slows Apr 11, 2008
State " Zip: Email: 12 ISSUES FOR $12.00 71% OFF! 24 ISSUES FOR $18.00 79% OFF! 36 ISSUES FOR $24.00 Best Deal! Print Send By Val Brickates Kennedy BOSTON (Dow Jones) -- Genentech Inc. reported a 12% boost in its bottom line late Thursday, largely due to increased sales for its cancer therapies Rituxan, Avastin and Herceptin. Genentech (DNA) posted net income of $790 million for the quarter ended March 31, compared with $706 million for the previous year's quarter. Earnings per share including... (SmartMoney)
Virginia's largest Cardiac Surgery program adopts SPY as standard of care Apr 8, 2008
Novadaq also offers the OPTTX(R) System, which leverages the company's core imaging technology and is designed for the diagnosis, evaluation and treatment of wet Age-related Macular Degeneration (AMD). For more information, please visit the company's website at. (Canada Newswire)
Age-Related Eye Disease on the Increase Apr 6, 2008
3 million of the more than 2 million Americans aged 50 and older that have age-related macular degeneration. And, approximately 6 million women and 3 million men have moderate to severe symptoms of dry eye syndrome, a condition caused when not enough natural tears are produced, according to the National Women's Health Resource Center. (Health-Finder)
Read more... Apr 4, 2008
Age-related macular degeneration (AMD) cases rose 25 percent, the largest increase of the major eye diseases. Currently, 2 million Americans have been diagnosed with AMD.. (PNN Online)
New Drug Could Save Sight Of Thousands Apr 2, 2008
The Royal National Institute for the Blind said a treatment of wet age-related macular degeneration - or AMD - is due to be approved by the health watchdog. AMD is the leading cause of sight loss in the UK and destroys the central region of the retina, the macula, leading to progressive loss of sight. (Sky News)
ThromboGenics Completes Patient Enrolment in the Phase IIb Trial of Microplasmin in Vitrectomy (MIVI III) Apr 1, 2008
Other major eye diseases that may benefit from nonsurgical PVD induction include diabetic retinopathy and age-related macular degeneration (AMD). Diabetic retinopathy is the leading cause of blindness among working-age adults, while AMD is the leading cause of blindness among the elderly. (PR Newswire)
DNA breakthroughs yield results Apr 1, 2008
One involves a leading cause of blindness in older people, age-related macular degeneration. A series of , the most recent in 2005, "led to huge breakthroughs in understanding" that disease, said Stephen Daiger, a Houston scientist. (Globe and Mail)
Indian-American red-flags gene cure Mar 30, 2008
Ambati team's finding arose out of research on mice using siRNA strands designed to tackle age-related macular degeneration (AMD), a form of blindness that strikes late in life and affects 50 million people worldwide. Two US companies are doing advanced trials aimed at fixing AMD by injecting siRNAs into the eye, based on the idea that the molecules enter cells and switch off the flawed gene that causes the problem. (India Times, India -- Health/Science)
Indian American Challenges Gene Cure Based On Nobel Winning Work Mar 29, 2008
The Ambati team's finding arose out of research on mice using siRNA strands designed to tackle age-related macular degeneration (AMD), a form of blindness that strikes late in life and affects 50 million people worldwide. Two US companies, Sirna Therapeutics - acquired by Merck for $1. (NEWSPost India)
Gene Silencing Therapies Could Have Harmful Side Effects, Research Suggests Mar 29, 2008
Many diseases including age-related macular degeneration, diabetes, kidney disease, cancer, Lou Gehrig's and Parkinson's have been heralded as candidates for siRNA therapy, creating a wave of on-going clinical trials. New Discovery Shows Therapies Could Have Harmful Side Effects. (Science Daily)
Get your antioxidants from food Mar 28, 2008
The Institutes of Medicine has concluded that there is little evidence that most Americans need antioxidant supplements, except people with age-related macular degeneration. They may benefit from a combination of antioxidants (500 milligrams of vitamin C, 400 IU of vitamin E, 15 milligrams of beta carotene, 80 milligrams of zinc and 2 milligrams of copper. (Marco Island Sun-Times, FL)
Triumphs and tribulations for RNA interference Mar 27, 2008
Jayakrishna Ambati at the University of Kentucky in Lexington and his colleagues studied the effects of RNAi on genes involved in a severe form of blindness called age-related macular degeneration (AMD). Trials of RNA-interfering drugs have already started in people with this disease but the latest findings go against the accepted grain of how the technique works. (Nature News Service)
The Dietitian Magician: Egg-citing news: An egg a day is OK Mar 26, 2008
Eye chart smart Substances found in certain vegetables and eggs have been found to be beneficial in reducing risk of cataracts and age-related macular degeneration ... These omega eggs have a much lower cholesterol content and are rich in heart-healthy omega-3 fats and naturally enhanced with more vitamin E. Designer eggs also contain extra lutein, which helps prevent age-related macular degeneration and cataracts. (Ames Daily Tribune, IA)
Vista Partners Initiates Coverage on Arana Therapeutics (ASX: AAH; AIM: AAHx) Mar 19, 2008
Additionally, the company has earlier stage products in development for the treatment of a range of conditions including age related macular degeneration, psoriasis, colorectal cancer, and leukemia. Arana has recurring revenues from commercial and development partnerships with six international companies including GSK, CSL, Centocor (J Abbott Laboratories. (PR Newswire)
Cocaine Use May Result in Heart Attack Symptoms in Youths Mar 19, 2008
By Anna Boyd 12:56, March 18th 2008. A new study by the American Heart Association warned Monday that cocaine use in young or otherwise healthy patients could sometimes cause heart attack symptoms like chest pain, shortness of breath, anxiety, palpitations, dizziness, nausea, heavy sweating and palpitations. (eFluxMedia)
Treating Macular Degeneration Mar 19, 2008
The two most common vascular eye diseases are age-related macular degeneration and diabetic retinopathy -- both caused primarily by abnormal blood vessel growth and leakage. When researchers activated the Robo4 protein in mice with simulated models of both diseases, they were able to prevent and even reverse the damage. (Ivanhoe)
New Hope For Regenerating Damaged Human Retina: Sleeping Stem Cells Successfully Awakened Mar 19, 2008
Neovascular age-related macular degeneration. (Credit: National Eye Institute, National Institutes of Health). (Science Daily)
Trials for 'bionic' eye implants Mar 19, 2008
5 million people worldwide have retinitis pigmentosa, and one in 10 people over the age of 55 have age-related macular degeneration. Both diseases cause the retinal cells which process light at the back of the eye to gradually die. (Yahoo News -- Disabilities and the Disabled)
Study Finds Potential Cause of Age-Related Macular Degeneration Mar 19, 2008
Though still preliminary, the University of Utah study suggests a new therapeutic target for such ophthalmic diseases as age-related macular degeneration (AMD) and diabetic retinopathy, as well as other conditions marked by inflammation and vascular leakiness, including cancer and certain traumatic injuries. "I think it is very strong science," said Dr. George A. Williams, chairman of the department of ophthalmology at William Beaumont Hospital in Royal Oak, Mich. (MEDLINEplus)
Protein 'reverses eye diseases' Mar 18, 2008
The proteins were activated in mice bred to mimic the effects of age-related macular degeneration (AMD) and diabetic retinopathy ... Dr Hemin Chin, from the US National Eye Institute, said: "Given that vascular eye diseases, such as age-related macular degeneration and diabetic retinopathy, are the number one cause of vision loss in the US, the identification of new signalling pathways that prevent abnormal vessel growth and leakage in the eye represents a major scientific advancement.". (BBC News -- Health)
QLT jumps as regulators clear way for sale of U.S. unit Mar 18, 2008
After selling the U.S. unit, QLT plans to hang on to its flagship eye drug for age-related macular degeneration, Visudyne. The change to the rules governing Aczone means patients will not have to undergo blood tests before they are given the drug. (Globe and Mail -- Business)
Drug to cure blindness is 'major breakthrough' Mar 18, 2008
Now it seems that age-related macular degeneration, along with a form of blindness that affects diabetics for the same reason, can be reversed or even prevented by injecting the drugs that activate a protein called Robo4 found in blood vessel cells, an American team announces in the journal Nature Medicine ... Robo4 was tested on mice that simulate age-related macular degeneration and diabetic retinopathy, according to Prof Dean Li senior author, who estimates that it could be tested on people... (Telegraph.co.uk)
Costly eye treatment now funded in Ontario Mar 17, 2008
"It really doesn't influence what we do or how we do it. Our reason for being involved in this is more than half our clients have [age-related macular degeneration]," he said. Search the News Search. (Globe and Mail)
The Seeing-Eye Gene Mar 17, 2008
has watched eight family members go blind, all as a result of age-related macular degeneration, or AMD, which afflicts 9 million people in the U.S. One-third of Americans over age 70 have it. Cox's eyes have signs of early degeneration, but she is determined to outwit her genes. (Forbes)
Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice Mar 17, 2008
SALT LAKE CITY Two major eye diseases and leading causes of blindnessage-related macular degeneration and diabetic retinopathycan be reversed or even prevented by drugs that activate a protein found in blood vessel cells, researchers at the University of Utah School of Medicine and several other institutions have announced in a new study. Damage from both diseases was prevented and even reversed when the protein, Robo4, was activated in mice models that simulate age-related macular... (EurekAlert!)
Nurse refused NHS funding to save her sight Mar 9, 2008
Cora Slade suffers from wet age-related macular degeneration. However, her local primary care trust has told her that it will not pay for treatment. (Telegraph.co.uk)
Was the promotion of HRT as an elixir of life a triumph of ... Mar 9, 2008
By the mid1990s researchers had claimed that HRT could reduce the risks of Alzheimer s, age-related macular degeneration, colon cancer, tooth loss, diabetes, Parkinson s disease and osteoporosis. That sounds good, doesn t it. (Times Online)
PDL stops sale, will cut 260 people Mar 6, 2008
of Japan will buy IV Busulfex for $200 million cash, and PDL said it would license volociximab, the antibody treatment of age-related macular degeneration to of Princeton, N.J., for undisclosed financial terms. (PDL and partner Biogen Idec will take an equity position in Ophthotech and receive milestone and royalty payments. (San Francisco Business Times, CA)
Don't Leave Your Vision to Chance on World Glaucoma Day Mar 5, 2008
Pfizer Ophthalmics also markets a treatment for neovascular age related macular degeneration outside the U.S. This same treatment is marketed in the U.S. by (OSI) Eyetech. Notes to Editors: Glaucoma is the name given to a series of devastating diseases that irreversibly damage the eye's optic nerve. (Canada Newswire)
Genes Involved In Inflammation May Hold Clue To Age-related Macular Degeneration Mar 5, 2008
4, 2008) A University of Southampton research team, led by Professor Andrew Lotery, has identified a new genetic risk factor for age-related macular degeneration (AMD), a major cause of untreatable blindness in elderly people in developed countries ... The paper 'Interleukin-B promoter polymorphism - 251A/T is a risk factor for age-related macular degeneration' is published online, ahead of print, by the British Journal of Ophthalmology ... 2, 2008) A new study of age-related macular... (Science Daily)
It's true: A veggie-rich diet will improve your vision Mar 5, 2008
Both are potent anti-oxidants thought to protect the eyes against damaging free radicals that may cause cataracts and age-related macular degeneration ... Another new study, reported by University of Sydney scientists in the journal Ophthalmology, found similar results linking higher lutein and zeaxanthin consumption to lower risk for age-related macular degeneration ... The Australian study also found that the mineral zinc was associated with a lower risk of age-related macular degeneration. (Atlanta Journal-Constitution -- Health)
1.8bn surplus forecast for NHS after cutbacks in patient care Mar 4, 2008
Last month a former Second World War airman, Jack Tagg, was told by his local primary care trust in Torbay, Devon, that he could not be given drug treatment for age-related macular degeneration because it was too expensive. The trust, which later relented but only on a technicality, is heading for a 7. (Times Online)
Three-way merger creates pharmaceutical company Mar 3, 2008
Those funds, plus an additional $16 million in cash held by eXegenics, will be used for the company's Phase III trial of bevasiranib, a maintenance therapy for wet age-related macular degeneration (AMD) of the eyes. That drug was being developed by Acuity. (South Florida Business Journal, FL)
Age-Related Macular Degeneration Doubles Heart Attack and Stroke Risk Mar 1, 2008
THURSDAY, Feb. 28 (HealthDay News) -- People suffering from age-related macular degeneration (AMD) have twice the risk of dying from heart attack or stroke, Australian researchers report ... "Age-related macular degeneration and atherosclerotic vascular share common risk factors that include hypertension, hyperlipidemia and smoking," said Dr. Gregg C. Fonarow, a professor of cardiology at the University of California, Los Angeles. (MEDLINEplus)
Study finds degenerative eye disease raises stroke risk Feb 28, 2008
LONDON (Reuters) - People with age-related macular degeneration, a leading cause of severe vision loss, have double the usual risk of dying from a heart attack or stroke, Australian researchers reported on Thursday. They found that for people under the age of 75 when the study began, those who developed early age-related macular degeneration had twice the risk of dying from a heart attack or stroke within the next decade ... "However, our finding that late age-related macular degeneration... (Scientific American)
Vitamin C can keep you healthy, looking younger Feb 28, 2008
Remember when vitamin C was hailed as the best, and maybe only, cold remedy. Then it became the Rodney Dangerfield of vitamins: It didn't get any respect. (CNN)
Eye disease linked to heart attacks Feb 28, 2008
University of Sydney researchers have found a link between cardiovascular disease and age-related macular degeneration (AMD), the most common eye disease affecting Australians. The finding has raised questions about a class of AMD medications that is believed to increase vascular risk. (The Age)
Patent Rejection Doesn't Faze Genentech Feb 27, 2008
Genentech products treat medical conditions including cancer, rheumatoid arthritis, heart attack, allergic asthma, psoriasis, stroke, growth hormone deficiency, cystic fibrosis and neovascular wet age-related macular degeneration. Swiss drugmaker Roche Holding (other-otc: - - ) owns 55. (Forbes -- Technology)
Health Watch: How survivors of violence heal from trauma Feb 26, 2008
HEALTH TIP: As part of its efforts to educate Americans about age-related macular degeneration, Prevent Blindness America has declared February Age-Related Macular Degeneration Awareness Month. The group reminds people that there's a link between healthy lifestyle habits and health eyes. (Marion Daily Republican, IL)
AMD discovery: New hope for treatment of vision loss Feb 21, 2008
Montreal, February 20, 2008 Scientists have won a major battle in the fight against age-related macular degeneration, or AMD, a blinding eye disease that affects millions of people ... Chemtob, a neonatal researcher at Sainte-Justine Hospital and a professor at the Universit de Montrals Department of Pediatrics and School of Optometry, used mice and rat models to pinpoint the scavenger receptor responsible for retinal degeneration typical of dry AMD. We found that a deficiency in CD36... (EurekAlert!)
Don't Lose Sight of Vision Care, Group Urges Feb 18, 2008
February is 'Age-Related Macular Degeneration Awareness Month ... SUNDAY, Feb. 17 (HealthDay News) -- As part of its efforts to educate Americans about age-related macular degeneration (AMD), Prevent Blindness America has declared February Age-Related Macular Degeneration Awareness Month. (Health-Finder)
War hero refused treatment by NHS Feb 18, 2008
The 88-year-old was recently diagnosed with age-related macular degeneration, the leading cause of blindness in Britain, which affects an estimated 500,000 people. advertisement. (Telegraph.co.uk)
Older Whites More Likely To Have Signs Of Future Eye Disease Than Blacks, Study Shows Feb 14, 2008
14, 2008) White individuals older than 65 are more likely than black individuals to have characteristics that indicate they will develop more advanced forms of the eye disease age-related macular degeneration (AMD), according to a new report. See also. (Science Daily)
Corneal Transplants Can Carry Infection Risk Feb 14, 2008
Another report in the same issue of the journal concludes that older white people are more likely to develop advanced forms of age-related macular degeneration than black people ... "Such data strongly suggest that white individuals are more likely to progress to advanced vision-disabling age-related macular degeneration (certainly to geographic atrophy) than black individuals," Bressler's team concluded ... The researchers also suggested that blacks may have a mechanism that protects them from... (MEDLINEplus)
NOVADAQ's SPY System to be Featured During Live Broadcast of Robotic Surgery Feb 12, 2008
Novadaq's OPTTX(R) System is aimed at the diagnosis, evaluation and treatment of wet Age-related Macular Degeneration (AMD) by using the same core imaging technology that is used in the SPY Imaging System. Novadaq also offers the FDA approved PINPOINT endoscopic system for visualizing native tissue fluorescence which allows surgeons to differentiate between healthy and cancerous tissue in the lung during thoracic surgery. (Canada Newswire)
Prevalence of common disease-associated variants in Asian Indians Feb 5, 2008
We investigated the prevalence of common polymorphisms that have been associated with diseases, such as atherosclerosis (ALOX5), hypertension (CYP3A5, AGT, GNB3), diabetes (CAPN10, TCF7L2, PTPN22), prostate cancer (DG8S737, rs1447295), Hirschsprung disease (RET), and age-related macular degeneration (CFH, LOC387715). In addition, we examined polymorphisms associated with skin pigmentation (SLC24A5) and with the ability to taste phenylthiocarbamide (TAS2R38). (BioMed Central)
XOMA to Present At BIO CEO and Investor Conference On February 11 Feb 4, 2008
XOMA's technologies and experienced team have contributed to the success of marketed antibody products, including RAPTIVA(r) (efalizumab) for chronic moderate to severe plaque psoriasis and LUCENTIS(r) (ranibizumab injection) for wet age-related macular degeneration. The Company has a premier antibody discovery and development platform that incorporates leading antibody phage display libraries and XOMA's proprietary Human Engineering and bacterial cell expression (BCE) technologies. (Primezone Releases)
Study Paves Way For Development Of Macular Degeneration Cures Feb 3, 2008
2, 2008) A new study of age-related macular degeneration (AMD), a disease that affects more than nine million Americans, will pave the way for the biopharmaceutical industry to develop better treatments and cures, according to the Foundation Fighting Blindness, which partially funded the research ... The study is titled "Oxidative damage-induced inflammation initiates age-related macular degeneration," and was published in the online edition of the scientific journal Nature Medicine on January... (Science Daily)
Scientists develop animal model with age-related macular degeneration Feb 1, 2008
London, Jan 31: Researchers at the Cleveland Clinic Lerner College of Medicine have generated an animal model representing age-related macular degeneration (AMD), thus paving a way for developing new and better therapeutic treatments. The team sensitized the immune systems in mice using oxidative chemicals and created AMD.. (TopNews)
Researchers query FDA about updating requirements for drug approval Feb 1, 2008
The discussion among the 30 participants focused on endpoints and clinical trial strategies for evaluating new treatments for age-related macular degeneration (AMD), diabetic retinopathy and other severe retinal disorders. The exchange is the subject of Report from the NEI/FDA Ophthalmic Clinical Trial Design and Endpoints Symposium, an article in the February 2008 issue of ARVOs peer-reviewed journal, Investigative Ophthalmology and Visual Science (). (EurekAlert!)
The business of restoring freedom Jan 31, 2008
The growing population of senior citizens has brought an increase in eye diseases such as age-related macular degeneration. Yet the trend is still too small to make waves in consumer products markets. (Sacramento Business Journal, CA)
Stemming effects of crippling ills Jan 30, 2008
EAST GREENBUSH -- At the New York Neural Stem Cell Institute here, researchers are examining potential treatments for age-related macular degeneration, Parkinson's disease, Alzheimer's disease, spinal cord injury and cancer ... And while Temple's group is pursuing treatments for age-related macular degeneration, a major cause of vision loss among older adults, Regeneron Pharmaceuticals Inc., which has a manufacturing plant next door and also is focusing on the disease, has developed a "trap"... (Albany Times Union)
Mouse Model of Age-Related Macular Degeneration Developed Jan 30, 2008
MONDAY, Jan. 28 (HealthDay News) -- The first animal model of age-related macular degeneration (AMD) has been developed by Cleveland Clinic researchers. This mouse model will help improve knowledge about the development and progression of the disease and will enable pre-clinical testing of new drugs for AMD, a leading cause of blindness in the elderly. (MEDLINEplus)
Sedentary Lifestyles Associated With Accelerated Aging Process Jan 29, 2008
2, 2006) Regular exercise can cut the likelihood of developing the degenerative eye disease, age related macular degeneration by 70 percent, suggests research published ahead of print in the British Journal. (Oct. (Science Daily)
Friday Club Holds January Meeting Jan 24, 2008
Kenneth has been treated for AMD (age-related macular degeneration) for four years. AMC is a deterioration or breakdown of the macula. (Park Hills Daily Journal, MO)
* Scientists team up for 1000 Genomes Project Jan 24, 2008
Researchers in the field have already cataloged dozens of specific regions of variation in the human genome, or haplotypes, and then associated them with common diseases like coronary artery disease, breast cancer, arthritis and age-related macular degeneration. But current DNA maps are not highly detailed, and researchers want a finer picture of the human genome to better pinpoint the genetic factors in disease. (Taipei Times, Taiwan -- World)
1000 Genomes: Most Detailed Map Of Human Genetic Variation To Support Disease Studies Jan 24, 2008
Using the HapMap and related resources, researchers already have discovered more than 100 regions of the genome containing genetic variants that are associated with risk of common human diseases such as diabetes, coronary artery disease, prostate and breast cancer, rheumatoid arthritis, inflammatory bowel disease and age-related macular degeneration. However, because existing maps are not extremely detailed, researchers often must follow those studies with costly and time-consuming DNA... (Science Daily)
The battle over two drug treatments Jan 23, 2008
In an e-mail, the company responded to the use of Avastin to treat the eye disease by saying, "it is not approved for intraocular [in the eye] use and is not indicated for treatment of AMD [age-related macular degeneration].". But to Mr. Cassels, an outspoken critic of the marketing practices of drug companies, the mounting pressure being placed on the government to fund expensive Lucentis treatments is a disturbing example of the industry's push for higher profits at the expense of affordable... (Globe and Mail)
World genomes project to promote research on human diseases Jan 23, 2008
Using the map, scientists will work out detail information on genome containing genetic variants that are associated with risk of common human diseases, such as diabetes, coronary artery disease, prostate and breast cancer, rheumatoid arthritis, inflammatory bowel disease and age-related macular degeneration. The new map would enable researchers to more quickly zero in on disease-related genetic variants, speeding efforts to use genetic information to develop new strategies for diagnosing,... (Xinhuanet, China)
The doctor will see you now! Jan 23, 2008
Biggest issues: glaucoma, cataracts and age-related macular degeneration. AFI (annoyance factor index): 3. (San Diego Union-Tribune)
Scientists Test The Safety Of Experimental Drug For Vision Loss Jan 22, 2008
The inflammatory component may be central to the development of age-related macular degeneration because it affects the survival of visual cells and also promotes new blood vessel growth, Kaushal said ... 7, 2005) The study found that early detection and treatment of age-related macular degeneration with pegaptanib sodium may enable AMD patients to maintain and, in some cases, regain. (Science Daily)